Lymph Node Dissection During Radical Nephro-Ureterectomy for Upper Tract Urothelial Carcinoma: A Review
Although lymphonodal dissection is well-accepted for muscle-invasive bladder cancer management, its role is still debated during radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). The aim of this study was to summarize the current knowledge concerning the indication, anato...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Surgery |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fsurg.2022.852969/full |
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| author | Arthur Peyrottes Gianluigi Califano Idir Ouzaïd Paul Lainé-Caroff Thibaut Long Depaquit Jean-François Hermieu Evanguelos Xylinas |
| author_facet | Arthur Peyrottes Gianluigi Califano Idir Ouzaïd Paul Lainé-Caroff Thibaut Long Depaquit Jean-François Hermieu Evanguelos Xylinas |
| author_sort | Arthur Peyrottes |
| collection | DOAJ |
| description | Although lymphonodal dissection is well-accepted for muscle-invasive bladder cancer management, its role is still debated during radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). The aim of this study was to summarize the current knowledge concerning the indication, anatomical template, prognostic, and therapeutic roles of lymph node dissection (LND) performed at the time of RNU. Quality control markers, such as the number of lymph nodes (LN) removed, lymph node density, and safety of the different surgical approaches, were assessed. We performed a narrative review using the PubMed and ClinicalTrials.gov databases. We identified and analyzed articles based on the practice and the role of lymph node dissection for non-metastatic UTUC. There are no clear guidelines regarding the indication of LND for UTUC, but aggressive tumors may beneficiate from lymphadenectomy since lymph node invasion is a clear independent poor prognostic factor, allowing for adjuvant treatments. It seems that an extended lymphadenectomy may provide therapeutic advantages as a higher number of nodes removed may be related to the removal of undetected LNs micrometastases and a subsequent improvement in recurrence rate and cancer-specific survival. Clear anatomical templates are thus needed based on the location and the laterality of the primary tumor. |
| first_indexed | 2024-04-12T22:24:04Z |
| format | Article |
| id | doaj.art-75914acbceca42d08dc3aca07ff7b968 |
| institution | Directory Open Access Journal |
| issn | 2296-875X |
| language | English |
| last_indexed | 2024-04-12T22:24:04Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Surgery |
| spelling | doaj.art-75914acbceca42d08dc3aca07ff7b9682022-12-22T03:14:13ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2022-03-01910.3389/fsurg.2022.852969852969Lymph Node Dissection During Radical Nephro-Ureterectomy for Upper Tract Urothelial Carcinoma: A ReviewArthur Peyrottes0Gianluigi Califano1Idir Ouzaïd2Paul Lainé-Caroff3Thibaut Long Depaquit4Jean-François Hermieu5Evanguelos Xylinas6Department of Urology, Bichat-Claude Bernard Hospital, Assistance-Publique Hôpitaux de Paris, Paris University, Paris, FranceUrology Unit, Department of Neurosciences, Reproductive Sciences and Odontostomatology, Federico II University of Naples, Naples, ItalyDepartment of Urology, Bichat-Claude Bernard Hospital, Assistance-Publique Hôpitaux de Paris, Paris University, Paris, FranceDepartment of Urology, Bichat-Claude Bernard Hospital, Assistance-Publique Hôpitaux de Paris, Paris University, Paris, FranceUrology Unit, Military Teaching Hospital Sainte Anne, French Military Health Service, Toulon, FranceDepartment of Urology, Bichat-Claude Bernard Hospital, Assistance-Publique Hôpitaux de Paris, Paris University, Paris, FranceDepartment of Urology, Bichat-Claude Bernard Hospital, Assistance-Publique Hôpitaux de Paris, Paris University, Paris, FranceAlthough lymphonodal dissection is well-accepted for muscle-invasive bladder cancer management, its role is still debated during radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). The aim of this study was to summarize the current knowledge concerning the indication, anatomical template, prognostic, and therapeutic roles of lymph node dissection (LND) performed at the time of RNU. Quality control markers, such as the number of lymph nodes (LN) removed, lymph node density, and safety of the different surgical approaches, were assessed. We performed a narrative review using the PubMed and ClinicalTrials.gov databases. We identified and analyzed articles based on the practice and the role of lymph node dissection for non-metastatic UTUC. There are no clear guidelines regarding the indication of LND for UTUC, but aggressive tumors may beneficiate from lymphadenectomy since lymph node invasion is a clear independent poor prognostic factor, allowing for adjuvant treatments. It seems that an extended lymphadenectomy may provide therapeutic advantages as a higher number of nodes removed may be related to the removal of undetected LNs micrometastases and a subsequent improvement in recurrence rate and cancer-specific survival. Clear anatomical templates are thus needed based on the location and the laterality of the primary tumor.https://www.frontiersin.org/articles/10.3389/fsurg.2022.852969/fulllymph node dissection (LND)upper tract urothelial carcinoma (UTUC)nephroureterectomyanatomical templatesreview |
| spellingShingle | Arthur Peyrottes Gianluigi Califano Idir Ouzaïd Paul Lainé-Caroff Thibaut Long Depaquit Jean-François Hermieu Evanguelos Xylinas Lymph Node Dissection During Radical Nephro-Ureterectomy for Upper Tract Urothelial Carcinoma: A Review Frontiers in Surgery lymph node dissection (LND) upper tract urothelial carcinoma (UTUC) nephroureterectomy anatomical templates review |
| title | Lymph Node Dissection During Radical Nephro-Ureterectomy for Upper Tract Urothelial Carcinoma: A Review |
| title_full | Lymph Node Dissection During Radical Nephro-Ureterectomy for Upper Tract Urothelial Carcinoma: A Review |
| title_fullStr | Lymph Node Dissection During Radical Nephro-Ureterectomy for Upper Tract Urothelial Carcinoma: A Review |
| title_full_unstemmed | Lymph Node Dissection During Radical Nephro-Ureterectomy for Upper Tract Urothelial Carcinoma: A Review |
| title_short | Lymph Node Dissection During Radical Nephro-Ureterectomy for Upper Tract Urothelial Carcinoma: A Review |
| title_sort | lymph node dissection during radical nephro ureterectomy for upper tract urothelial carcinoma a review |
| topic | lymph node dissection (LND) upper tract urothelial carcinoma (UTUC) nephroureterectomy anatomical templates review |
| url | https://www.frontiersin.org/articles/10.3389/fsurg.2022.852969/full |
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