Evaluating antibiotic regimens for streptococcal toxic shock syndrome in children.
<h4>Introduction</h4>Streptococcal toxic shock syndrome (STSS) is a severe consequence of infections from Streptococcus pyogenes. The early identification and timely intervention with appropriate anti-infective agents are pivotal for managing pediatric STSS. This study evaluates the effe...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0292311&type=printable |
| _version_ | 1797649572623810560 |
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| author | Haixia Zhang Jie Dong Jiaotian Huang Keyuan Zhang Xiulan Lu Xin Zhao Changqiong Xiao |
| author_facet | Haixia Zhang Jie Dong Jiaotian Huang Keyuan Zhang Xiulan Lu Xin Zhao Changqiong Xiao |
| author_sort | Haixia Zhang |
| collection | DOAJ |
| description | <h4>Introduction</h4>Streptococcal toxic shock syndrome (STSS) is a severe consequence of infections from Streptococcus pyogenes. The early identification and timely intervention with appropriate anti-infective agents are pivotal for managing pediatric STSS. This study evaluates the effectiveness of various treatment regimens for STSS in children.<h4>Methods</h4>Clinical data of children with STSS resulting from β-hemolytic streptococcal infections in two hospitals were retrospectively analyzed from January 2009 to April 2023. Additionally, literature from the China National Knowledge Infrastructure on pediatric STSS was examined. Antimicrobial treatments were categorized into four groups based on their compositions, with an additional categorization for adjunct therapeutic drugs.<h4>Results</h4>Of 32 confirmed STSS cases, all displayed sensitivity to ampicillin, β-lactam antibiotics, and vancomycin, but resistance to clindamycin, erythromycin, and tetracycline. From the literature, 23 studies with 50 cases were extracted, leading to a total of 82 patients for evaluation. The efficacy rates varied significantly among the four treatment groups. Notably, the standard penicillin-containing group exhibited the highest efficacy (86.4%), while the group with macrolides/unused antibiotics registered a 0% efficacy rate. The other two groups demonstrated efficacy rates of 32.1% and 42.3%.<h4>Conclusion</h4>For pediatric STSS, Streptococcus pyogenes shows notable sensitivity to ampicillin. Implementing timely β-lactam antibiotics, specifically penicillin, in conjunction with clindamycin and intravenous immunoglobulins enhances the treatment success rate. |
| first_indexed | 2024-03-11T15:49:01Z |
| format | Article |
| id | doaj.art-7591a9505d44487bba442cfd77d61e7e |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-03-11T15:49:01Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-7591a9505d44487bba442cfd77d61e7e2023-10-26T05:31:58ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-011810e029231110.1371/journal.pone.0292311Evaluating antibiotic regimens for streptococcal toxic shock syndrome in children.Haixia ZhangJie DongJiaotian HuangKeyuan ZhangXiulan LuXin ZhaoChangqiong Xiao<h4>Introduction</h4>Streptococcal toxic shock syndrome (STSS) is a severe consequence of infections from Streptococcus pyogenes. The early identification and timely intervention with appropriate anti-infective agents are pivotal for managing pediatric STSS. This study evaluates the effectiveness of various treatment regimens for STSS in children.<h4>Methods</h4>Clinical data of children with STSS resulting from β-hemolytic streptococcal infections in two hospitals were retrospectively analyzed from January 2009 to April 2023. Additionally, literature from the China National Knowledge Infrastructure on pediatric STSS was examined. Antimicrobial treatments were categorized into four groups based on their compositions, with an additional categorization for adjunct therapeutic drugs.<h4>Results</h4>Of 32 confirmed STSS cases, all displayed sensitivity to ampicillin, β-lactam antibiotics, and vancomycin, but resistance to clindamycin, erythromycin, and tetracycline. From the literature, 23 studies with 50 cases were extracted, leading to a total of 82 patients for evaluation. The efficacy rates varied significantly among the four treatment groups. Notably, the standard penicillin-containing group exhibited the highest efficacy (86.4%), while the group with macrolides/unused antibiotics registered a 0% efficacy rate. The other two groups demonstrated efficacy rates of 32.1% and 42.3%.<h4>Conclusion</h4>For pediatric STSS, Streptococcus pyogenes shows notable sensitivity to ampicillin. Implementing timely β-lactam antibiotics, specifically penicillin, in conjunction with clindamycin and intravenous immunoglobulins enhances the treatment success rate.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0292311&type=printable |
| spellingShingle | Haixia Zhang Jie Dong Jiaotian Huang Keyuan Zhang Xiulan Lu Xin Zhao Changqiong Xiao Evaluating antibiotic regimens for streptococcal toxic shock syndrome in children. PLoS ONE |
| title | Evaluating antibiotic regimens for streptococcal toxic shock syndrome in children. |
| title_full | Evaluating antibiotic regimens for streptococcal toxic shock syndrome in children. |
| title_fullStr | Evaluating antibiotic regimens for streptococcal toxic shock syndrome in children. |
| title_full_unstemmed | Evaluating antibiotic regimens for streptococcal toxic shock syndrome in children. |
| title_short | Evaluating antibiotic regimens for streptococcal toxic shock syndrome in children. |
| title_sort | evaluating antibiotic regimens for streptococcal toxic shock syndrome in children |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0292311&type=printable |
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