Clinical Usefulness of a timed overnight (8 hours) Urine Albumin (microalbumin) Excretion in monitor- ing treatment in benign essential hypertension
Aims and objectives: This research aims to establish the usefulness of timed over- night (8 hours) Urine Albumin(microalbumin) Excretion (UAE), in monitoring therapy in Nigerian patients with benign essential hypertension. Subjects and Methods: The study population comprised 40 normotensives/con-...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-01-01
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| Series: | Nigerian Postgraduate Medical Journal |
| Subjects: | |
| Online Access: | http://www.npmj.org/article.asp?issn=1117-1936;year=2014;volume=21;issue=2;spage=177;epage=180;aulast=Oluwatowoju |
| _version_ | 1818492549090770944 |
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| author | I O Oluwatowoju JNA Ajuluchukwu O A Afonja |
| author_facet | I O Oluwatowoju JNA Ajuluchukwu O A Afonja |
| author_sort | I O Oluwatowoju |
| collection | DOAJ |
| description | Aims and objectives: This research aims to establish the usefulness of timed over- night (8 hours) Urine Albumin(microalbumin) Excretion (UAE), in monitoring therapy in Nigerian patients with benign essential hypertension.
Subjects and Methods: The study population comprised 40 normotensives/con- trols, (23 males and 17 females) aged between 20-70 years, with a mean blood pressure 116/75mmHg, 30 well-controlled hypertensive patients, diastolic BP < 100mmHg or MAP (mean arterial pressure) = 110mmHg and 30 poorly con- trolled hypertensive patients, diastolic blood pressure > 100mmHg or MAP > 110mmHg. albumin(microalbumin) was determined on the 8 hours overnight urine samples by ELISA method using kit from Randox Laboratories Limited, N. Ireland Cat No. MA 1410. UAE was calculated from the urine albumin concentration, urine volume and collection time. The intra assay precision was determined by running 20 replicates of two kit controls in a single batch. The coefficient of variation was 6.6% at 10.70mg/L and 4.3% at 51.20mg/L.
Results: The average UAE in the three groups were as follows: 12:22 +/- 4.65μg/ min, 21.50 +/- 10.5μg/min and 30.10 +/- 24.25 μg/min in the control, well con- trolled and poorly controlled groups respectively, 12.5% of normotensive sub- jects, 40% of well controlled and 56.7% of poorly controlled patients were found to have microalbuminuria.
The UAE increased significantly with the severity of hypertension (r = 0.32, p<0.001 for control) r = 0.38, p<0.05 for controlled and r = 0.49 p<0.05 for poorly controlled.
Conclusion:A timed overnight (8 hours) Urinary UAE is a preferred alternative to cumbersome 24 hours urine collection for monitoring response to treatment in Nigerian patients with benign essential hypertension. |
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| format | Article |
| id | doaj.art-7591bfc764504ed7bd4cb9d8501c3207 |
| institution | Directory Open Access Journal |
| issn | 1117-1936 2468-6875 |
| language | English |
| last_indexed | 2024-12-10T17:44:44Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Nigerian Postgraduate Medical Journal |
| spelling | doaj.art-7591bfc764504ed7bd4cb9d8501c32072022-12-22T01:39:16ZengWolters Kluwer Medknow PublicationsNigerian Postgraduate Medical Journal1117-19362468-68752014-01-01212177180Clinical Usefulness of a timed overnight (8 hours) Urine Albumin (microalbumin) Excretion in monitor- ing treatment in benign essential hypertensionI O OluwatowojuJNA AjuluchukwuO A AfonjaAims and objectives: This research aims to establish the usefulness of timed over- night (8 hours) Urine Albumin(microalbumin) Excretion (UAE), in monitoring therapy in Nigerian patients with benign essential hypertension. Subjects and Methods: The study population comprised 40 normotensives/con- trols, (23 males and 17 females) aged between 20-70 years, with a mean blood pressure 116/75mmHg, 30 well-controlled hypertensive patients, diastolic BP < 100mmHg or MAP (mean arterial pressure) = 110mmHg and 30 poorly con- trolled hypertensive patients, diastolic blood pressure > 100mmHg or MAP > 110mmHg. albumin(microalbumin) was determined on the 8 hours overnight urine samples by ELISA method using kit from Randox Laboratories Limited, N. Ireland Cat No. MA 1410. UAE was calculated from the urine albumin concentration, urine volume and collection time. The intra assay precision was determined by running 20 replicates of two kit controls in a single batch. The coefficient of variation was 6.6% at 10.70mg/L and 4.3% at 51.20mg/L. Results: The average UAE in the three groups were as follows: 12:22 +/- 4.65μg/ min, 21.50 +/- 10.5μg/min and 30.10 +/- 24.25 μg/min in the control, well con- trolled and poorly controlled groups respectively, 12.5% of normotensive sub- jects, 40% of well controlled and 56.7% of poorly controlled patients were found to have microalbuminuria. The UAE increased significantly with the severity of hypertension (r = 0.32, p<0.001 for control) r = 0.38, p<0.05 for controlled and r = 0.49 p<0.05 for poorly controlled. Conclusion:A timed overnight (8 hours) Urinary UAE is a preferred alternative to cumbersome 24 hours urine collection for monitoring response to treatment in Nigerian patients with benign essential hypertension.http://www.npmj.org/article.asp?issn=1117-1936;year=2014;volume=21;issue=2;spage=177;epage=180;aulast=Oluwatowojuurine albumin excretionessential hypertension |
| spellingShingle | I O Oluwatowoju JNA Ajuluchukwu O A Afonja Clinical Usefulness of a timed overnight (8 hours) Urine Albumin (microalbumin) Excretion in monitor- ing treatment in benign essential hypertension Nigerian Postgraduate Medical Journal urine albumin excretion essential hypertension |
| title | Clinical Usefulness of a timed overnight (8 hours) Urine Albumin (microalbumin) Excretion in monitor- ing treatment in benign essential hypertension |
| title_full | Clinical Usefulness of a timed overnight (8 hours) Urine Albumin (microalbumin) Excretion in monitor- ing treatment in benign essential hypertension |
| title_fullStr | Clinical Usefulness of a timed overnight (8 hours) Urine Albumin (microalbumin) Excretion in monitor- ing treatment in benign essential hypertension |
| title_full_unstemmed | Clinical Usefulness of a timed overnight (8 hours) Urine Albumin (microalbumin) Excretion in monitor- ing treatment in benign essential hypertension |
| title_short | Clinical Usefulness of a timed overnight (8 hours) Urine Albumin (microalbumin) Excretion in monitor- ing treatment in benign essential hypertension |
| title_sort | clinical usefulness of a timed overnight 8 hours urine albumin microalbumin excretion in monitor ing treatment in benign essential hypertension |
| topic | urine albumin excretion essential hypertension |
| url | http://www.npmj.org/article.asp?issn=1117-1936;year=2014;volume=21;issue=2;spage=177;epage=180;aulast=Oluwatowoju |
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