Allatostatin A Signalling: Progress and New Challenges From a Paradigmatic Pleiotropic Invertebrate Neuropeptide Family
Neuropeptides have gained broad attraction in insect neuroscience and physiology, as new genetic tools are increasingly uncovering their wide-ranging pleiotropic functions with high cellular resolution. Allatostatin A (AstA) peptides constitute one of the best studied insect neuropeptide families. I...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2022.920529/full |
| _version_ | 1818156855260610560 |
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| author | Christian Wegener Jiangtian Chen |
| author_facet | Christian Wegener Jiangtian Chen |
| author_sort | Christian Wegener |
| collection | DOAJ |
| description | Neuropeptides have gained broad attraction in insect neuroscience and physiology, as new genetic tools are increasingly uncovering their wide-ranging pleiotropic functions with high cellular resolution. Allatostatin A (AstA) peptides constitute one of the best studied insect neuropeptide families. In insects and other panarthropods, AstA peptides qualify as brain-gut peptides and have regained attention with the discovery of their role in regulating feeding, growth, activity/sleep and learning. AstA receptor homologs are found throughout the protostomia and group with vertebrate somatostatin/galanin/kisspeptin receptors. In this review, we summarise the current knowledge on the evolution and the pleiotropic and cell-specific non-allatostatic functions of AstA. We speculate about the core functions of AstA signalling, and derive open questions and challengesfor future research on AstA and invertebrate neuropeptides in general. |
| first_indexed | 2024-12-11T15:04:56Z |
| format | Article |
| id | doaj.art-75920acbe5ef447eaf76f9b6929b0a11 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-11T15:04:56Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-75920acbe5ef447eaf76f9b6929b0a112022-12-22T01:00:59ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2022-06-011310.3389/fphys.2022.920529920529Allatostatin A Signalling: Progress and New Challenges From a Paradigmatic Pleiotropic Invertebrate Neuropeptide FamilyChristian Wegener0Jiangtian Chen1Neurobiology and Genetics, Würzburg Insect Research, Theodor-Boveri-Institute, Biocenter, University of Würzburg, Würzburg, GermanyDepartment of Ecology, Evolution and Organismal Biology, Brown University, Providence, RI, United StatesNeuropeptides have gained broad attraction in insect neuroscience and physiology, as new genetic tools are increasingly uncovering their wide-ranging pleiotropic functions with high cellular resolution. Allatostatin A (AstA) peptides constitute one of the best studied insect neuropeptide families. In insects and other panarthropods, AstA peptides qualify as brain-gut peptides and have regained attention with the discovery of their role in regulating feeding, growth, activity/sleep and learning. AstA receptor homologs are found throughout the protostomia and group with vertebrate somatostatin/galanin/kisspeptin receptors. In this review, we summarise the current knowledge on the evolution and the pleiotropic and cell-specific non-allatostatic functions of AstA. We speculate about the core functions of AstA signalling, and derive open questions and challengesfor future research on AstA and invertebrate neuropeptides in general.https://www.frontiersin.org/articles/10.3389/fphys.2022.920529/fullneuropeptide signallingfeedingintestinal controlsleep/activitykisspeptin/galanin/spexin signallingmetabolism and growth |
| spellingShingle | Christian Wegener Jiangtian Chen Allatostatin A Signalling: Progress and New Challenges From a Paradigmatic Pleiotropic Invertebrate Neuropeptide Family Frontiers in Physiology neuropeptide signalling feeding intestinal control sleep/activity kisspeptin/galanin/spexin signalling metabolism and growth |
| title | Allatostatin A Signalling: Progress and New Challenges From a Paradigmatic Pleiotropic Invertebrate Neuropeptide Family |
| title_full | Allatostatin A Signalling: Progress and New Challenges From a Paradigmatic Pleiotropic Invertebrate Neuropeptide Family |
| title_fullStr | Allatostatin A Signalling: Progress and New Challenges From a Paradigmatic Pleiotropic Invertebrate Neuropeptide Family |
| title_full_unstemmed | Allatostatin A Signalling: Progress and New Challenges From a Paradigmatic Pleiotropic Invertebrate Neuropeptide Family |
| title_short | Allatostatin A Signalling: Progress and New Challenges From a Paradigmatic Pleiotropic Invertebrate Neuropeptide Family |
| title_sort | allatostatin a signalling progress and new challenges from a paradigmatic pleiotropic invertebrate neuropeptide family |
| topic | neuropeptide signalling feeding intestinal control sleep/activity kisspeptin/galanin/spexin signalling metabolism and growth |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2022.920529/full |
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