Gain of chromosome region 18q21 including the MALT1 gene is associated with the activated B-cell-like gene expression subtype and increased BCL2 gene dosage and protein expression in diffuse large B-cell lymphoma

Gain of chromosome region 18q21 including the MALT1 gene is associated with the activated B-cell-like gene expression subtype and increased BCL2 gene dosage and protein expression in diffuse large B-cell lymphoma

Background The aim of this study was to determine the impact of a gain of the MALT1 gene on gene expression and clinical parameters in diffuse large B-cell lymphoma.Design and Methods We analyzed 116 cases of diffuse large B-cell lymphoma by fluorescence in situ hybridization, array-based comparativ...

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Detalles Bibliográficos
Autores principales: Judith Dierlamm, Eva M. Murga Penas, Stefan Bentink, Swen Wessendorf, Hilmar Berger, Michael Hummel, Wolfram Klapper, Dido Lenze, Andreas Rosenwald, Eugenia Haralambieva, German Ott, Sergio B. Cogliatti, Peter Möller, Carsten Schwaenen, Harald Stein, Markus Löffler, Rainer Spang, Lorenz Trümper, Reiner Siebert, for the Deutsche Krebshilfe Network Project “Molecular Mechanisms in Malignant Lymphomas”
Formato: Artículo
Lenguaje:English
Publicado: Ferrata Storti Foundation 2008-05-01
Colección:Haematologica
Acceso en línea:https://haematologica.org/article/view/4841

Internet

https://haematologica.org/article/view/4841

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