Expression dynamics of ISGs and chemokines in maternal whole blood as an indicator of healthy embryonic implantation in buffalo
Successful pregnancy establishment has a major influence on reproductive efficiencies of dairy buffaloes. This success depends on coordinated communications between conceptus and maternally derived cells, and any disturbance in this communication network during this process leads to early embryonic...
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| Format: | Article |
| Language: | English |
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Indian Council of Agricultural Research
2022-10-01
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| Series: | Indian Journal of Animal Sciences |
| Subjects: | |
| Online Access: | https://epubs.icar.org.in/index.php/IJAnS/article/view/125604 |
| _version_ | 1811169106721767424 |
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| author | RAJNI KUMARI SHANKER DAYAL ROHAN KUMAR RAMAN P C CHANDRAN SANJAY KUMAR PRADEEP KUMAR RAY REENA KAMAL JYOTI KUMAR AMITAVA DEY KAMAL SARMA UJJWAL KUMAR |
| author_facet | RAJNI KUMARI SHANKER DAYAL ROHAN KUMAR RAMAN P C CHANDRAN SANJAY KUMAR PRADEEP KUMAR RAY REENA KAMAL JYOTI KUMAR AMITAVA DEY KAMAL SARMA UJJWAL KUMAR |
| author_sort | RAJNI KUMARI |
| collection | DOAJ |
| description |
Successful pregnancy establishment has a major influence on reproductive efficiencies of dairy buffaloes. This success depends on coordinated communications between conceptus and maternally derived cells, and any disturbance in this communication network during this process leads to early embryonic losses. Since, early embryonic losses is one of the prime cause of pregnancy failure in dairy buffaloes, present investigation was aimed to understand the expression dynamics and correlation pattern of Interferon tau stimulated genes and chemokines during peri-implantation period in dairy buffaloes through transcriptional profiling followed by Principal Component Analysis. Our study revealed upregulation of all the candidate genes in maternal whole blood across the parity, emphasizing the involvement of immune responses as signatures for healthy pregnancy. Understanding these embryo-maternal communication signals offers potential to prevent incidences of early embryonic losses and can provide insights on possible targets for therapy too.
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| first_indexed | 2024-04-10T16:36:48Z |
| format | Article |
| id | doaj.art-75926b3197264268838e08b0cdfe3f09 |
| institution | Directory Open Access Journal |
| issn | 0367-8318 2394-3327 |
| language | English |
| last_indexed | 2024-04-10T16:36:48Z |
| publishDate | 2022-10-01 |
| publisher | Indian Council of Agricultural Research |
| record_format | Article |
| series | Indian Journal of Animal Sciences |
| spelling | doaj.art-75926b3197264268838e08b0cdfe3f092023-02-08T11:22:46ZengIndian Council of Agricultural ResearchIndian Journal of Animal Sciences0367-83182394-33272022-10-01921010.56093/ijans.v92i10.125604Expression dynamics of ISGs and chemokines in maternal whole blood as an indicator of healthy embryonic implantation in buffaloRAJNI KUMARI0SHANKER DAYAL1ROHAN KUMAR RAMAN2P C CHANDRAN3SANJAY KUMAR4PRADEEP KUMAR RAY5REENA KAMAL6JYOTI KUMAR7AMITAVA DEY8KAMAL SARMA9UJJWAL KUMAR10ICAR Research Complex for Eastern Region, Patna, BiharICAR Research Complex for Eastern Region, Patna, Bihar 800 014 IndiaICAR Research Complex for Eastern Region, Patna, Bihar 800 014 IndiaICAR Research Complex for Eastern Region, Patna, Bihar 800 014 IndiaBihar Veterinary College, Patna, BiharICAR Research Complex for Eastern Region, Patna, Bihar 800 014 IndiaICAR Research Complex for Eastern Region, Patna, Bihar 800 014 IndiaICAR Research Complex for Eastern Region, Patna, Bihar 800 014 IndiaICAR Research Complex for Eastern Region, Patna, Bihar 800 014 IndiaICAR Research Complex for Eastern Region, Patna, Bihar 800 014 IndiaICAR Research Complex for Eastern Region, Patna, Bihar 800 014 India Successful pregnancy establishment has a major influence on reproductive efficiencies of dairy buffaloes. This success depends on coordinated communications between conceptus and maternally derived cells, and any disturbance in this communication network during this process leads to early embryonic losses. Since, early embryonic losses is one of the prime cause of pregnancy failure in dairy buffaloes, present investigation was aimed to understand the expression dynamics and correlation pattern of Interferon tau stimulated genes and chemokines during peri-implantation period in dairy buffaloes through transcriptional profiling followed by Principal Component Analysis. Our study revealed upregulation of all the candidate genes in maternal whole blood across the parity, emphasizing the involvement of immune responses as signatures for healthy pregnancy. Understanding these embryo-maternal communication signals offers potential to prevent incidences of early embryonic losses and can provide insights on possible targets for therapy too. https://epubs.icar.org.in/index.php/IJAnS/article/view/125604Buffalo, Chemokines, Embryo maternal signaling, Early embryonic losses, ISGs |
| spellingShingle | RAJNI KUMARI SHANKER DAYAL ROHAN KUMAR RAMAN P C CHANDRAN SANJAY KUMAR PRADEEP KUMAR RAY REENA KAMAL JYOTI KUMAR AMITAVA DEY KAMAL SARMA UJJWAL KUMAR Expression dynamics of ISGs and chemokines in maternal whole blood as an indicator of healthy embryonic implantation in buffalo Indian Journal of Animal Sciences Buffalo, Chemokines, Embryo maternal signaling, Early embryonic losses, ISGs |
| title | Expression dynamics of ISGs and chemokines in maternal whole blood as an indicator of healthy embryonic implantation in buffalo |
| title_full | Expression dynamics of ISGs and chemokines in maternal whole blood as an indicator of healthy embryonic implantation in buffalo |
| title_fullStr | Expression dynamics of ISGs and chemokines in maternal whole blood as an indicator of healthy embryonic implantation in buffalo |
| title_full_unstemmed | Expression dynamics of ISGs and chemokines in maternal whole blood as an indicator of healthy embryonic implantation in buffalo |
| title_short | Expression dynamics of ISGs and chemokines in maternal whole blood as an indicator of healthy embryonic implantation in buffalo |
| title_sort | expression dynamics of isgs and chemokines in maternal whole blood as an indicator of healthy embryonic implantation in buffalo |
| topic | Buffalo, Chemokines, Embryo maternal signaling, Early embryonic losses, ISGs |
| url | https://epubs.icar.org.in/index.php/IJAnS/article/view/125604 |
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