Correlation between Mild Traumatic Brain Injury-Induced Inflammatory Cytokines and Emotional Symptom Traits: A Systematic Review
Both mild traumatic brain injuries (mTBI) and systemic injuries trigger a transient neuroinflammatory response that result in similar clinical outcome. The ensuing physical, cognitive, and emotional symptoms fail to subside in approximately 15–20% of the concussed population. Emotional impairments,...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-01-01
|
| Series: | Brain Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3425/12/1/102 |
| _version_ | 1827666254237794304 |
|---|---|
| author | Shazia Malik Omar Alnaji Mahnoor Malik Teresa Gambale Michel Piers Rathbone |
| author_facet | Shazia Malik Omar Alnaji Mahnoor Malik Teresa Gambale Michel Piers Rathbone |
| author_sort | Shazia Malik |
| collection | DOAJ |
| description | Both mild traumatic brain injuries (mTBI) and systemic injuries trigger a transient neuroinflammatory response that result in similar clinical outcome. The ensuing physical, cognitive, and emotional symptoms fail to subside in approximately 15–20% of the concussed population. Emotional impairments, particularly depression, anxiety, and post-traumatic stress disorder (PTSD), are commonly associated with poor recovery following mTBI. These emotional impairments also have a significant neuroinflammatory component. We hypothesized that the inflammatory cytokines seen in mTBI patients with emotional symptoms would coincide with those commonly seen in patients with emotional symptoms without mTBI. A systematic review was conducted to identify the most common neuroinflammatory cytokines in the mTBI population with psychological symptoms (depression, anxiety, PTSD). The electronic databases EMBASE, MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL), PUBMED, and PSYCINFO were searched from data inception to 31 August 2021. A systematic screening approach was employed from screening to data analysis. A total of 994 articles were screened, 108 were selected for full article review, and 8 were selected for data analysis. The included studies consisted of 875 patients of which 81.3% were male. The mean sample size of patients with at least one mTBI was 73.8 ± 70.3 (range, 9–213), with a mean age of 33.9 ± 4.8 years. The most common cytokines associated with poor psychological outcomes involving PTSD and/or depression in the chronic mTBI population were IL-6, TNFα, IL-10, and CRP. |
| first_indexed | 2024-03-10T01:48:13Z |
| format | Article |
| id | doaj.art-75933d04c453433bb49efbf58cc1a71f |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T01:48:13Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-75933d04c453433bb49efbf58cc1a71f2023-11-23T13:10:11ZengMDPI AGBrain Sciences2076-34252022-01-0112110210.3390/brainsci12010102Correlation between Mild Traumatic Brain Injury-Induced Inflammatory Cytokines and Emotional Symptom Traits: A Systematic ReviewShazia Malik0Omar Alnaji1Mahnoor Malik2Teresa Gambale3Michel Piers Rathbone4Neurosciences Graduate Program, McMaster University, Hamilton, ON L8S 4L8, CanadaFaculty of Life Sciences, McMaster University, Hamilton, ON L8S 4L8, CanadaBachelor of Health Sciences Program, McMaster University, Hamilton, ON L8S 4L8, CanadaDivision of Neurology, Department of Medicine, McMaster University, Hamilton, ON L8S 4L8, CanadaDivision of Neurology, Department of Medicine, McMaster University, Hamilton, ON L8S 4L8, CanadaBoth mild traumatic brain injuries (mTBI) and systemic injuries trigger a transient neuroinflammatory response that result in similar clinical outcome. The ensuing physical, cognitive, and emotional symptoms fail to subside in approximately 15–20% of the concussed population. Emotional impairments, particularly depression, anxiety, and post-traumatic stress disorder (PTSD), are commonly associated with poor recovery following mTBI. These emotional impairments also have a significant neuroinflammatory component. We hypothesized that the inflammatory cytokines seen in mTBI patients with emotional symptoms would coincide with those commonly seen in patients with emotional symptoms without mTBI. A systematic review was conducted to identify the most common neuroinflammatory cytokines in the mTBI population with psychological symptoms (depression, anxiety, PTSD). The electronic databases EMBASE, MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL), PUBMED, and PSYCINFO were searched from data inception to 31 August 2021. A systematic screening approach was employed from screening to data analysis. A total of 994 articles were screened, 108 were selected for full article review, and 8 were selected for data analysis. The included studies consisted of 875 patients of which 81.3% were male. The mean sample size of patients with at least one mTBI was 73.8 ± 70.3 (range, 9–213), with a mean age of 33.9 ± 4.8 years. The most common cytokines associated with poor psychological outcomes involving PTSD and/or depression in the chronic mTBI population were IL-6, TNFα, IL-10, and CRP.https://www.mdpi.com/2076-3425/12/1/102concussionmild traumatic brain injuryinflammatory cytokinesneuroinflammationdepressionPTSD |
| spellingShingle | Shazia Malik Omar Alnaji Mahnoor Malik Teresa Gambale Michel Piers Rathbone Correlation between Mild Traumatic Brain Injury-Induced Inflammatory Cytokines and Emotional Symptom Traits: A Systematic Review Brain Sciences concussion mild traumatic brain injury inflammatory cytokines neuroinflammation depression PTSD |
| title | Correlation between Mild Traumatic Brain Injury-Induced Inflammatory Cytokines and Emotional Symptom Traits: A Systematic Review |
| title_full | Correlation between Mild Traumatic Brain Injury-Induced Inflammatory Cytokines and Emotional Symptom Traits: A Systematic Review |
| title_fullStr | Correlation between Mild Traumatic Brain Injury-Induced Inflammatory Cytokines and Emotional Symptom Traits: A Systematic Review |
| title_full_unstemmed | Correlation between Mild Traumatic Brain Injury-Induced Inflammatory Cytokines and Emotional Symptom Traits: A Systematic Review |
| title_short | Correlation between Mild Traumatic Brain Injury-Induced Inflammatory Cytokines and Emotional Symptom Traits: A Systematic Review |
| title_sort | correlation between mild traumatic brain injury induced inflammatory cytokines and emotional symptom traits a systematic review |
| topic | concussion mild traumatic brain injury inflammatory cytokines neuroinflammation depression PTSD |
| url | https://www.mdpi.com/2076-3425/12/1/102 |
| work_keys_str_mv | AT shaziamalik correlationbetweenmildtraumaticbraininjuryinducedinflammatorycytokinesandemotionalsymptomtraitsasystematicreview AT omaralnaji correlationbetweenmildtraumaticbraininjuryinducedinflammatorycytokinesandemotionalsymptomtraitsasystematicreview AT mahnoormalik correlationbetweenmildtraumaticbraininjuryinducedinflammatorycytokinesandemotionalsymptomtraitsasystematicreview AT teresagambale correlationbetweenmildtraumaticbraininjuryinducedinflammatorycytokinesandemotionalsymptomtraitsasystematicreview AT michelpiersrathbone correlationbetweenmildtraumaticbraininjuryinducedinflammatorycytokinesandemotionalsymptomtraitsasystematicreview |