Interchromosomal interaction of homologous Stat92E alleles regulates transcriptional switch during stem-cell differentiation
Asymmetric inheritance of organelles, proteins and RNAs occurs during stem cell division. Here the authors show the strength of pairing of homologous Stat92E loci, a stem cell-specific gene, changes immediately after the asymmetric division due to asymmetric inheritance of new histones to one of the...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-31737-y |
| _version_ | 1818488777238118400 |
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| author | Matthew Antel Romir Raj Madona Y. G. Masoud Ziwei Pan Sheng Li Barbara G. Mellone Mayu Inaba |
| author_facet | Matthew Antel Romir Raj Madona Y. G. Masoud Ziwei Pan Sheng Li Barbara G. Mellone Mayu Inaba |
| author_sort | Matthew Antel |
| collection | DOAJ |
| description | Asymmetric inheritance of organelles, proteins and RNAs occurs during stem cell division. Here the authors show the strength of pairing of homologous Stat92E loci, a stem cell-specific gene, changes immediately after the asymmetric division due to asymmetric inheritance of new histones to one of the daughter cells and is important for turning off gene expression in this cell as it differentiates. |
| first_indexed | 2024-12-10T16:55:31Z |
| format | Article |
| id | doaj.art-7593a06aff9543c2bd02b4a21d10e440 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-10T16:55:31Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-7593a06aff9543c2bd02b4a21d10e4402022-12-22T01:40:46ZengNature PortfolioNature Communications2041-17232022-07-0113111610.1038/s41467-022-31737-yInterchromosomal interaction of homologous Stat92E alleles regulates transcriptional switch during stem-cell differentiationMatthew Antel0Romir Raj1Madona Y. G. Masoud2Ziwei Pan3Sheng Li4Barbara G. Mellone5Mayu Inaba6Department of Cell Biology, University of Connecticut Health CenterDepartment of Cell Biology, University of Connecticut Health CenterDepartment of Cell Biology, University of Connecticut Health CenterThe Jackson Laboratory for Genomic MedicineThe Jackson Laboratory for Genomic MedicineDepartment of Molecular and Cell Biology, University of ConnecticutDepartment of Cell Biology, University of Connecticut Health CenterAsymmetric inheritance of organelles, proteins and RNAs occurs during stem cell division. Here the authors show the strength of pairing of homologous Stat92E loci, a stem cell-specific gene, changes immediately after the asymmetric division due to asymmetric inheritance of new histones to one of the daughter cells and is important for turning off gene expression in this cell as it differentiates.https://doi.org/10.1038/s41467-022-31737-y |
| spellingShingle | Matthew Antel Romir Raj Madona Y. G. Masoud Ziwei Pan Sheng Li Barbara G. Mellone Mayu Inaba Interchromosomal interaction of homologous Stat92E alleles regulates transcriptional switch during stem-cell differentiation Nature Communications |
| title | Interchromosomal interaction of homologous Stat92E alleles regulates transcriptional switch during stem-cell differentiation |
| title_full | Interchromosomal interaction of homologous Stat92E alleles regulates transcriptional switch during stem-cell differentiation |
| title_fullStr | Interchromosomal interaction of homologous Stat92E alleles regulates transcriptional switch during stem-cell differentiation |
| title_full_unstemmed | Interchromosomal interaction of homologous Stat92E alleles regulates transcriptional switch during stem-cell differentiation |
| title_short | Interchromosomal interaction of homologous Stat92E alleles regulates transcriptional switch during stem-cell differentiation |
| title_sort | interchromosomal interaction of homologous stat92e alleles regulates transcriptional switch during stem cell differentiation |
| url | https://doi.org/10.1038/s41467-022-31737-y |
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