Current knowledge and challenges associated with targeted delivery of neurotrophic factors into the central nervous system: focus on available approaches
Abstract During the last decades, numerous basic and clinical studies have been conducted to assess the delivery efficiency of therapeutic agents into the brain and spinal cord parenchyma using several administration routes. Among conventional and in-progress administrative routes, the eligibility o...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-10-01
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| Series: | Cell & Bioscience |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13578-021-00694-2 |
| _version_ | 1819122982749995008 |
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| author | Gozal Bahlakeh Reza Rahbarghazi Daruosh Mohammadnejad Ali Abedelahi Mohammad Karimipour |
| author_facet | Gozal Bahlakeh Reza Rahbarghazi Daruosh Mohammadnejad Ali Abedelahi Mohammad Karimipour |
| author_sort | Gozal Bahlakeh |
| collection | DOAJ |
| description | Abstract During the last decades, numerous basic and clinical studies have been conducted to assess the delivery efficiency of therapeutic agents into the brain and spinal cord parenchyma using several administration routes. Among conventional and in-progress administrative routes, the eligibility of stem cells, viral vectors, and biomaterial systems have been shown in the delivery of NTFs. Despite these manifold advances, the close association between the delivery system and regeneration outcome remains unclear. Herein, we aimed to discuss recent progress in the delivery of these factors and the pros and cons related to each modality. |
| first_indexed | 2024-12-22T07:01:07Z |
| format | Article |
| id | doaj.art-7594238a879d42a1a60d74a599aacdbb |
| institution | Directory Open Access Journal |
| issn | 2045-3701 |
| language | English |
| last_indexed | 2024-12-22T07:01:07Z |
| publishDate | 2021-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell & Bioscience |
| spelling | doaj.art-7594238a879d42a1a60d74a599aacdbb2022-12-21T18:34:48ZengBMCCell & Bioscience2045-37012021-10-0111112410.1186/s13578-021-00694-2Current knowledge and challenges associated with targeted delivery of neurotrophic factors into the central nervous system: focus on available approachesGozal Bahlakeh0Reza Rahbarghazi1Daruosh Mohammadnejad2Ali Abedelahi3Mohammad Karimipour4Neurosciences Research Center (NSRC), Tabriz University of Medical SciencesStem Cell Research Center, Tabriz University of Medical SciencesDepartment of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical SciencesDepartment of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical SciencesDepartment of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical SciencesAbstract During the last decades, numerous basic and clinical studies have been conducted to assess the delivery efficiency of therapeutic agents into the brain and spinal cord parenchyma using several administration routes. Among conventional and in-progress administrative routes, the eligibility of stem cells, viral vectors, and biomaterial systems have been shown in the delivery of NTFs. Despite these manifold advances, the close association between the delivery system and regeneration outcome remains unclear. Herein, we aimed to discuss recent progress in the delivery of these factors and the pros and cons related to each modality.https://doi.org/10.1186/s13578-021-00694-2Neurotrophic factorsDelivery systemNeuroregenerationAdministration routes |
| spellingShingle | Gozal Bahlakeh Reza Rahbarghazi Daruosh Mohammadnejad Ali Abedelahi Mohammad Karimipour Current knowledge and challenges associated with targeted delivery of neurotrophic factors into the central nervous system: focus on available approaches Cell & Bioscience Neurotrophic factors Delivery system Neuroregeneration Administration routes |
| title | Current knowledge and challenges associated with targeted delivery of neurotrophic factors into the central nervous system: focus on available approaches |
| title_full | Current knowledge and challenges associated with targeted delivery of neurotrophic factors into the central nervous system: focus on available approaches |
| title_fullStr | Current knowledge and challenges associated with targeted delivery of neurotrophic factors into the central nervous system: focus on available approaches |
| title_full_unstemmed | Current knowledge and challenges associated with targeted delivery of neurotrophic factors into the central nervous system: focus on available approaches |
| title_short | Current knowledge and challenges associated with targeted delivery of neurotrophic factors into the central nervous system: focus on available approaches |
| title_sort | current knowledge and challenges associated with targeted delivery of neurotrophic factors into the central nervous system focus on available approaches |
| topic | Neurotrophic factors Delivery system Neuroregeneration Administration routes |
| url | https://doi.org/10.1186/s13578-021-00694-2 |
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