Contact prediction is hardest for the most informative contacts, but improves with the incorporation of contact potentials.
Co-evolution between pairs of residues in a multiple sequence alignment (MSA) of homologous proteins has long been proposed as an indicator of structural contacts. Recently, several methods, such as direct-coupling analysis (DCA) and MetaPSICOV, have been shown to achieve impressive rates of contact...
| Main Authors: | , , |
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| Format: | Article |
| Sprog: | English |
| Udgivet: |
Public Library of Science (PLoS)
2018-01-01
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| Serier: | PLoS ONE |
| Online adgang: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0199585&type=printable |