SPECTRUM OF RENAL ALLOGRAFT BIOPSY FINDINGS IN RENAL TRANSPLANT PATIENTS AT A TERTIARY CARE CENTER IN RAWALPINDI, PAKISTAN
Objective: To evaluate outcome of diagnostic kidney biopsy in patients with renal allograft dysfunction at a tertiary care hospital. Study Design: Retrospective observational study. Place and Duration of Study: Armed Forces Institute of Urology, Rawalpindi, from Jan 2014 to Jan 2020. Method...
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| Format: | Article |
| Language: | English |
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Army Medical College Rawalpindi
2021-06-01
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| Series: | Pakistan Armed Forces Medical Journal |
| Subjects: | |
| Online Access: | https://pafmj.org/index.php/PAFMJ/article/view/4304 |
| _version_ | 1818734905241108480 |
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| author | Khurram Mansoor Muhammad Osama Muhammad Ishaque Sohail Sabir Hafeez ud Din Muhammad Asif Haroon Sabir |
| author_facet | Khurram Mansoor Muhammad Osama Muhammad Ishaque Sohail Sabir Hafeez ud Din Muhammad Asif Haroon Sabir |
| author_sort | Khurram Mansoor |
| collection | DOAJ |
| description | Objective: To evaluate outcome of diagnostic kidney biopsy in patients with renal allograft dysfunction at a tertiary care hospital.
Study Design: Retrospective observational study.
Place and Duration of Study: Armed Forces Institute of Urology, Rawalpindi, from Jan 2014 to Jan 2020.
Methodology: A consolidate registry review was carried to formulate this study. The registry data exists at our center containing information about the graft dysfunction (manifesting as proteinuria, deranged urea and creatinine or urine sediment abnormalities) and other major indications which warrant probing with biopsy. The histopathological diagnosis of these biopsies is confirmed from the nephro-pathology registry before finalization of diagnosis.
Results: A total of 94 diagnostic kidney biopsies were performed in patients with graft dysfunction. Out of 94 biopsies, 80 (85.1%) patients were male while 14 (14.9%) were female patients. The most frequent single cause for graft dysfunction was Cell Mediated Rejection (n 12, 24.5%) followed by Interstitial Fibrosis and Tubular Atrophy/Acute Tubular Injury. The most common cause among the glomerulonephritis was Membranoproliferative Glomerulonephritis (n 3, 6.1%) followed by others. The most common cause for mixed pathology remainedcell mediated rejection with Interstitial fibrosis and tubular atrophy (n 8, 17.8%).
Conclusion: Cell mediated rejection is thecommonest pathology responsible for renal allograft dysfunction both as a single lesion as well as part of mixed pathology. |
| first_indexed | 2024-12-18T00:12:44Z |
| format | Article |
| id | doaj.art-7597bcb68512497796e59423d243e6ae |
| institution | Directory Open Access Journal |
| issn | 0030-9648 2411-8842 |
| language | English |
| last_indexed | 2024-12-18T00:12:44Z |
| publishDate | 2021-06-01 |
| publisher | Army Medical College Rawalpindi |
| record_format | Article |
| series | Pakistan Armed Forces Medical Journal |
| spelling | doaj.art-7597bcb68512497796e59423d243e6ae2022-12-21T21:27:37ZengArmy Medical College RawalpindiPakistan Armed Forces Medical Journal0030-96482411-88422021-06-017139424610.51253/pafmj.v71i3.43044304SPECTRUM OF RENAL ALLOGRAFT BIOPSY FINDINGS IN RENAL TRANSPLANT PATIENTS AT A TERTIARY CARE CENTER IN RAWALPINDI, PAKISTANKhurram Mansoor0Muhammad Osama1Muhammad Ishaque2Sohail Sabir3Hafeez ud Din4Muhammad Asif5Haroon Sabir6Armed Forces Institute of Urology/National University of Medical Sciences (NUMS) Rawalpindi PakistanArmed Forces Institute of Urology/National University of Medical Sciences (NUMS) Rawalpindi PakistanArmed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi PakistanArmed Forces Institute of Urology/National University of Medical Sciences (NUMS) Rawalpindi PakistanArmed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi PakistanArmed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi PakistanPakistan Naval Ship Shifa Karachi PakistanObjective: To evaluate outcome of diagnostic kidney biopsy in patients with renal allograft dysfunction at a tertiary care hospital. Study Design: Retrospective observational study. Place and Duration of Study: Armed Forces Institute of Urology, Rawalpindi, from Jan 2014 to Jan 2020. Methodology: A consolidate registry review was carried to formulate this study. The registry data exists at our center containing information about the graft dysfunction (manifesting as proteinuria, deranged urea and creatinine or urine sediment abnormalities) and other major indications which warrant probing with biopsy. The histopathological diagnosis of these biopsies is confirmed from the nephro-pathology registry before finalization of diagnosis. Results: A total of 94 diagnostic kidney biopsies were performed in patients with graft dysfunction. Out of 94 biopsies, 80 (85.1%) patients were male while 14 (14.9%) were female patients. The most frequent single cause for graft dysfunction was Cell Mediated Rejection (n 12, 24.5%) followed by Interstitial Fibrosis and Tubular Atrophy/Acute Tubular Injury. The most common cause among the glomerulonephritis was Membranoproliferative Glomerulonephritis (n 3, 6.1%) followed by others. The most common cause for mixed pathology remainedcell mediated rejection with Interstitial fibrosis and tubular atrophy (n 8, 17.8%). Conclusion: Cell mediated rejection is thecommonest pathology responsible for renal allograft dysfunction both as a single lesion as well as part of mixed pathology.https://pafmj.org/index.php/PAFMJ/article/view/4304allograft dysfunctioncell-mediated rejectionrenal biopsy |
| spellingShingle | Khurram Mansoor Muhammad Osama Muhammad Ishaque Sohail Sabir Hafeez ud Din Muhammad Asif Haroon Sabir SPECTRUM OF RENAL ALLOGRAFT BIOPSY FINDINGS IN RENAL TRANSPLANT PATIENTS AT A TERTIARY CARE CENTER IN RAWALPINDI, PAKISTAN Pakistan Armed Forces Medical Journal allograft dysfunction cell-mediated rejection renal biopsy |
| title | SPECTRUM OF RENAL ALLOGRAFT BIOPSY FINDINGS IN RENAL TRANSPLANT PATIENTS AT A TERTIARY CARE CENTER IN RAWALPINDI, PAKISTAN |
| title_full | SPECTRUM OF RENAL ALLOGRAFT BIOPSY FINDINGS IN RENAL TRANSPLANT PATIENTS AT A TERTIARY CARE CENTER IN RAWALPINDI, PAKISTAN |
| title_fullStr | SPECTRUM OF RENAL ALLOGRAFT BIOPSY FINDINGS IN RENAL TRANSPLANT PATIENTS AT A TERTIARY CARE CENTER IN RAWALPINDI, PAKISTAN |
| title_full_unstemmed | SPECTRUM OF RENAL ALLOGRAFT BIOPSY FINDINGS IN RENAL TRANSPLANT PATIENTS AT A TERTIARY CARE CENTER IN RAWALPINDI, PAKISTAN |
| title_short | SPECTRUM OF RENAL ALLOGRAFT BIOPSY FINDINGS IN RENAL TRANSPLANT PATIENTS AT A TERTIARY CARE CENTER IN RAWALPINDI, PAKISTAN |
| title_sort | spectrum of renal allograft biopsy findings in renal transplant patients at a tertiary care center in rawalpindi pakistan |
| topic | allograft dysfunction cell-mediated rejection renal biopsy |
| url | https://pafmj.org/index.php/PAFMJ/article/view/4304 |
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