Release of High-Mobility Group Box-1 after a Raynaud’s Attack Leads to Fibroblast Activation and Interferon-γ Induced Protein-10 Production: Role in Systemic Sclerosis Pathogenesis

Release of High-Mobility Group Box-1 after a Raynaud’s Attack Leads to Fibroblast Activation and Interferon-γ Induced Protein-10 Production: Role in Systemic Sclerosis Pathogenesis

Raynaud’s Phenomenon (RP) leading to repetitive ischemia and reperfusion (IR) stress, is the first recognizable sign of systemic sclerosis (SSc) leading to increased oxidative stress. High-mobility group box-1 (HMGB1) is a nuclear factor released by apoptotic and necrotic cells after oxidative stres...

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Bibliographic Details
Main Authors: Yehya Al-Adwi, Isabella M. Atzeni, Berber Doornbos-van der Meer, Amaal Eman Abdulle, Anniek M. van Roon, Alja Stel, Harry van Goor, Andries J. Smit, Johanna Westra, Douwe J. Mulder
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Antioxidants
Subjects:
injury
ischemia and reperfusion
Raynaud’s phenomenon
SSc
IP-10
HMGB1
Online Access:https://www.mdpi.com/2076-3921/12/4/794

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