Lactobacillus crispatus dominance in the vaginal microbiome reduces the occurrence of spontaneous preterm birth in women with a short cervical length
Introduction: The majority of pregnant women with a short cervix will deliver at term and, thus, may unnecessarily receive advanced monitoring and treatment. It is still necessary to define more accurately which sub-population of women with a short cervix is at elevated risk for early delivery. Obj...
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| Format: | Article |
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Zeppelini Editorial e Comunicacao
2022-05-01
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| Series: | DST |
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| Online Access: | https://www.bjstd.org/revista/article/view/1198 |
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| author | Antonio Fernandes Moron Steven Sol Witkin Iara Moreno Linhares Alan Roberto Hatanaka Stéphanno Gomes Pereira Sarmento Marcelo Santucci França Francisco Herlânio Costa Carvalho Rosiane Mattar Larry Jay Forney |
| author_facet | Antonio Fernandes Moron Steven Sol Witkin Iara Moreno Linhares Alan Roberto Hatanaka Stéphanno Gomes Pereira Sarmento Marcelo Santucci França Francisco Herlânio Costa Carvalho Rosiane Mattar Larry Jay Forney |
| author_sort | Antonio Fernandes Moron |
| collection | DOAJ |
| description |
Introduction: The majority of pregnant women with a short cervix will deliver at term and, thus, may unnecessarily receive advanced monitoring and
treatment. It is still necessary to define more accurately which sub-population of women with a short cervix is at elevated risk for early delivery. Objective:
To determine if vaginal microbiome composition influenced the rate of spontaneous preterm birth in women with a short cervical length. Methods: In an
exploratory, observational prospective study, vaginal secretions were obtained from 591 women at 21–24 week gestation. Vaginal microbiome composition
was determined by analyzing the V1–V3 region of the bacterial 16S ribosomal RNA gene. Results: Lactobacillus crispatus was numerically dominant in
the vagina in 41.7% of subjects, followed by L. iners in 32% and Gardnerella vaginalis in 12%. In women whose cervix was ≤25mm, the sensitivity to
predict an spontaneous preterm birth was 11.8%. However, when L. crispatus was not the dominant vaginal bacterium, this sensitivity increased to 81.8%.
Similarly, in women with a cervical length ≤30mm, the sensitivity to predict an spontaneous preterm birth increased from 21.7 to 78.3% when L. crispatus
was not the dominant vaginal bacterium. In women with a prior spontaneous preterm birth and a cervix ≤25 or ≤30mm, L. crispatus dominance was also
associated with a reduced rate of spontaneous preterm birth in the current pregnancy (p<0.001). Conclusion: In pregnant women with a cervix ≤25mm or
≤30mm, the risk for an spontaneous preterm birth is increased if L. crispatus is not dominant in the vagina.
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| first_indexed | 2024-04-10T19:57:14Z |
| format | Article |
| id | doaj.art-7598919e8947492a83e644c1a1a70440 |
| institution | Directory Open Access Journal |
| issn | 2177-8264 |
| language | English |
| last_indexed | 2024-04-10T19:57:14Z |
| publishDate | 2022-05-01 |
| publisher | Zeppelini Editorial e Comunicacao |
| record_format | Article |
| series | DST |
| spelling | doaj.art-7598919e8947492a83e644c1a1a704402023-01-27T18:17:40ZengZeppelini Editorial e ComunicacaoDST2177-82642022-05-013410.5327/DST-2177-8264-20223407Lactobacillus crispatus dominance in the vaginal microbiome reduces the occurrence of spontaneous preterm birth in women with a short cervical length Antonio Fernandes Moron0 Steven Sol Witkin1Iara Moreno Linhares2Alan Roberto Hatanaka3 Stéphanno Gomes Pereira Sarmento4Marcelo Santucci França5Francisco Herlânio Costa Carvalho6Rosiane Mattar7Larry Jay Forney8Universidade Federal de São PauloWeill Cornell MedicineUniversidade de São PauloUniversidade Federal de São PauloUniversidade Federal de São PauloUniversidade Federal de São PauloUniversidade Federal do CearáUniversidade Federal de São PauloUniversity of Idaho Introduction: The majority of pregnant women with a short cervix will deliver at term and, thus, may unnecessarily receive advanced monitoring and treatment. It is still necessary to define more accurately which sub-population of women with a short cervix is at elevated risk for early delivery. Objective: To determine if vaginal microbiome composition influenced the rate of spontaneous preterm birth in women with a short cervical length. Methods: In an exploratory, observational prospective study, vaginal secretions were obtained from 591 women at 21–24 week gestation. Vaginal microbiome composition was determined by analyzing the V1–V3 region of the bacterial 16S ribosomal RNA gene. Results: Lactobacillus crispatus was numerically dominant in the vagina in 41.7% of subjects, followed by L. iners in 32% and Gardnerella vaginalis in 12%. In women whose cervix was ≤25mm, the sensitivity to predict an spontaneous preterm birth was 11.8%. However, when L. crispatus was not the dominant vaginal bacterium, this sensitivity increased to 81.8%. Similarly, in women with a cervical length ≤30mm, the sensitivity to predict an spontaneous preterm birth increased from 21.7 to 78.3% when L. crispatus was not the dominant vaginal bacterium. In women with a prior spontaneous preterm birth and a cervix ≤25 or ≤30mm, L. crispatus dominance was also associated with a reduced rate of spontaneous preterm birth in the current pregnancy (p<0.001). Conclusion: In pregnant women with a cervix ≤25mm or ≤30mm, the risk for an spontaneous preterm birth is increased if L. crispatus is not dominant in the vagina. https://www.bjstd.org/revista/article/view/1198Cervical length measurementLactobacillus crispatusMycobiomePregnancyObstetric labor, premature |
| spellingShingle | Antonio Fernandes Moron Steven Sol Witkin Iara Moreno Linhares Alan Roberto Hatanaka Stéphanno Gomes Pereira Sarmento Marcelo Santucci França Francisco Herlânio Costa Carvalho Rosiane Mattar Larry Jay Forney Lactobacillus crispatus dominance in the vaginal microbiome reduces the occurrence of spontaneous preterm birth in women with a short cervical length DST Cervical length measurement Lactobacillus crispatus Mycobiome Pregnancy Obstetric labor, premature |
| title | Lactobacillus crispatus dominance in the vaginal microbiome reduces the occurrence of spontaneous preterm birth in women with a short cervical length |
| title_full | Lactobacillus crispatus dominance in the vaginal microbiome reduces the occurrence of spontaneous preterm birth in women with a short cervical length |
| title_fullStr | Lactobacillus crispatus dominance in the vaginal microbiome reduces the occurrence of spontaneous preterm birth in women with a short cervical length |
| title_full_unstemmed | Lactobacillus crispatus dominance in the vaginal microbiome reduces the occurrence of spontaneous preterm birth in women with a short cervical length |
| title_short | Lactobacillus crispatus dominance in the vaginal microbiome reduces the occurrence of spontaneous preterm birth in women with a short cervical length |
| title_sort | lactobacillus crispatus dominance in the vaginal microbiome reduces the occurrence of spontaneous preterm birth in women with a short cervical length |
| topic | Cervical length measurement Lactobacillus crispatus Mycobiome Pregnancy Obstetric labor, premature |
| url | https://www.bjstd.org/revista/article/view/1198 |
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