Deletion of <i>Gtf2i</i> via Systemic Administration of AAV-PHP.eB Virus Increases Social Behavior in a Mouse Model of a Neurodevelopmental Disorder

Deletion of <i>Gtf2i</i> via Systemic Administration of AAV-PHP.eB Virus Increases Social Behavior in a Mouse Model of a Neurodevelopmental Disorder

Williams syndrome (WS) is a neurodevelopmental disorder characterized by distinctive cognitive and personality profiles which also impacts various physiological systems. The syndrome arises from the deletion of about 25 genes located on chromosome 7q11.23, including <i>Gtf2i</i>. Prior r...

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Bibliographic Details
Main Authors: Omer Ophir, Gilad Levy, Ela Bar, Omri Kimchi Feldhorn, May Rokach, Galit Elad Sfadia, Boaz Barak
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Biomedicines
Subjects:
Williams syndrome (WS)
<i>Gtf2i</i>
adeno-associated virus (AAV)
PHP.eB serotype
post-natal deletion
excitatory neurons
Online Access:https://www.mdpi.com/2227-9059/11/8/2273

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