Drug affinity-responsive target stability unveils filamins as biological targets for artemetin, an anti-cancer flavonoid
Artemetin is a valuable 5-hydroxy-3,6,7,3′,4′-pentamethoxyflavone present in many different medicinal plants with very good oral bioavailability and drug-likeness values, owing to numerous bioactivities, such as anti-inflammatory and anti-cancer ones. Here, a multi-disciplinary plan has been settled...
Main Authors: | Giusy Ferraro, Raffaella Belvedere, Antonello Petrella, Alessandra Tosco, Björn Stork, Stefano Salamone, Alberto Minassi, Federica Pollastro, Elva Morretta, Maria Chiara Monti |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2022-08-01
|
Series: | Frontiers in Molecular Biosciences |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2022.964295/full |
Similar Items
-
Biomimetic Approaches to the Synthesis of Natural Disesquiterpenoids: An Update
by: Diego Caprioglio, et al.
Published: (2021-04-01) -
Targeting phosphoglycerate kinases by tatridin A, a natural sesquiterpenoid endowed with anti-cancer activity, using a proteomic platform
by: Giusy Ferraro, et al.
Published: (2023-09-01) -
Exploring the Universe of Natural Products: Recent Advances in Synthesis, Isolation and Structural Elucidation
by: Federica Pollastro, et al.
Published: (2021-11-01) -
Cannabinerol (CBNR) Influences Synaptic Genes Associated with Cytoskeleton and Ion Channels in NSC-34 Cell Line: A Transcriptomic Study
by: Osvaldo Artimagnella, et al.
Published: (2024-01-01) -
Transcriptomic Profiling after In Vitro Δ<sup>8</sup>-THC Exposure Shows Cytoskeletal Remodeling in Trauma-Injured NSC-34 Cell Line
by: Luigi Chiricosta, et al.
Published: (2023-09-01)