Relationship of Lipid Profile and Serum Ferritin levels with Acute Myocardial Infarction
Introduction: National Health and Nutrition Examination Survey (NHANES III), 1988-1994, first time reported a significant, positive association in iron storage and heart disease risk. Thereafter several researchers have found an association between iron overload, serum ferritin (SF) and MI. No s...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2014-08-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/4694/8018_CE(Ra)_F(Sh)_PF1(PAK)_PFA(P).pdf |
| Summary: | Introduction: National Health and Nutrition Examination Survey
(NHANES III), 1988-1994, first time reported a significant,
positive association in iron storage and heart disease risk.
Thereafter several researchers have found an association
between iron overload, serum ferritin (SF) and MI. No such
Indian study was available in the literature and so we decided
to find out the relation of lipid profile and Serum Ferritin with
myocardial infarction (MI).
Materials and Methods: Fifty indian patients of AMI (study
group) and fifty indian healthy volunteers (control group) were
included for the present study. Lipid profile including TC,
HDL-c, LDL-c, VLDL-c & TG and SF levels were estimated in
all subjects.
Observations and Results: Mean ± SD of TC level was 250.64
± 25.61, of HDL-c was 36.52 ± 2.86, of LDL-c was 165.69 ±
26.80, of VLDL-c was 42.35 ± 8.53 and of TG was 211.83 ±
42.65 in study group while these values were 174.46±47.68,
43.2±12.52, 98.37±41.13, 32.88±21.45 and 164.42±107.29
respectively in control group. All the parameters were found not
only raised in patients of acute myocardial infarction (AMI) but
were also statistically significant when compared with control
group (p=<0.01).
Mean ± SD of SF levels was 268.43±30.17 ng/ml in study group
and 110.96±56.5 ng/ml in control group; this level was found
not only raised in patients of AMI but were also statistically
significant when compared with control group (p=<0.01).
Conclusion: TC, LDL-c, VLDL-c, TG and SF levels were raised
in patients of AMI and found to be statistically significant;
while HDL-c levels were reduced in such patients and is also
statistically significant. It can be concluded that there exists an
association in lipid profile and SF with AMI therefore dyslipidemia
and raised SF levels are the features of AMI. |
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| ISSN: | 2249-782X 0973-709X |