Association of Secondary Hyperparathyroidism with Hemoglobin Level in Patients with Chronic Kidney Disease
Purpose: Secondary hyperparathyroidism (SHPT) is one of the less recognized reasons of anemia in chronic kidney disease (CKD). In this study, we evaluated the role of SHPT as a cause of anemia and correlation of intact parathyroid hormone (iPTH) and hemoglobin (Hb) level in hemodialysis (HD) patient...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Thieme Medical and Scientific Publishers Pvt. Ltd.
2013-01-01
|
| Series: | Journal of Laboratory Physicians |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.4103/0974-2727.115935 |
| _version_ | 1818967581630922752 |
|---|---|
| author | Happy Chutia Alice Abraham Ruram Himashree Bhattacharyya Polina Boruah Chandan Nath |
| author_facet | Happy Chutia Alice Abraham Ruram Himashree Bhattacharyya Polina Boruah Chandan Nath |
| author_sort | Happy Chutia |
| collection | DOAJ |
| description | Purpose: Secondary hyperparathyroidism (SHPT) is one of the less recognized reasons of anemia in chronic kidney disease (CKD). In this study, we evaluated the role of SHPT as a cause of anemia and correlation of intact parathyroid hormone (iPTH) and hemoglobin (Hb) level in hemodialysis (HD) patients.
Methods: This cross-sectional study was carried out in 63 individuals admitted in HD unit of the institute. Serum samples were collected and urea, creatinine, Hb, ferritin and iPTH levels were measured. Statistical analysis was carried out using the SPSS software (IBM, NY, USA).
Results: Mean ± standard deviation for serum urea, creatinine, Hb, ferritin and intact PTH were 177 ± 15.52, 15.16 ± 2.28 mg/dl, 7.03 ± 2.26 g/dl, 654.7 ± 563.4 ng/ml, 539.18 ± 493.59 pg/ml respectively. A reverse correlation was found between intact PTH and Hb level.
Conclusions: A variety of postulated pathophysiological mechanisms linking SHPT and anemia in CKD are discussed. An efficient control of parathyroid hormone hypersecretion may be required to achieve a better management of anemia in HD patients. |
| first_indexed | 2024-12-20T13:51:04Z |
| format | Article |
| id | doaj.art-759c8dc6815d45ffaa6e392a7e8903cf |
| institution | Directory Open Access Journal |
| issn | 0974-2727 0974-7826 |
| language | English |
| last_indexed | 2024-12-20T13:51:04Z |
| publishDate | 2013-01-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Journal of Laboratory Physicians |
| spelling | doaj.art-759c8dc6815d45ffaa6e392a7e8903cf2022-12-21T19:38:30ZengThieme Medical and Scientific Publishers Pvt. Ltd.Journal of Laboratory Physicians0974-27270974-78262013-01-01501515410.4103/0974-2727.115935Association of Secondary Hyperparathyroidism with Hemoglobin Level in Patients with Chronic Kidney DiseaseHappy Chutia0Alice Abraham Ruram1Himashree Bhattacharyya2Polina Boruah3Chandan Nath4Department of Biochemistry, North East Indira Gandhi Institute of Health and Medical Science, Shillong, Meghalaya, IndiaDepartment of Biochemistry, North East Indira Gandhi Institute of Health and Medical Science, Shillong, Meghalaya, IndiaDepartment of Community Medicine, North East Indira Gandhi Institute of Health and Medical Science, Shillong, Meghalaya, IndiaDepartment of Biochemistry, North East Indira Gandhi Institute of Health and Medical Science, Shillong, Meghalaya, IndiaDepartment of Biochemistry, North East Indira Gandhi Institute of Health and Medical Science, Shillong, Meghalaya, IndiaPurpose: Secondary hyperparathyroidism (SHPT) is one of the less recognized reasons of anemia in chronic kidney disease (CKD). In this study, we evaluated the role of SHPT as a cause of anemia and correlation of intact parathyroid hormone (iPTH) and hemoglobin (Hb) level in hemodialysis (HD) patients. Methods: This cross-sectional study was carried out in 63 individuals admitted in HD unit of the institute. Serum samples were collected and urea, creatinine, Hb, ferritin and iPTH levels were measured. Statistical analysis was carried out using the SPSS software (IBM, NY, USA). Results: Mean ± standard deviation for serum urea, creatinine, Hb, ferritin and intact PTH were 177 ± 15.52, 15.16 ± 2.28 mg/dl, 7.03 ± 2.26 g/dl, 654.7 ± 563.4 ng/ml, 539.18 ± 493.59 pg/ml respectively. A reverse correlation was found between intact PTH and Hb level. Conclusions: A variety of postulated pathophysiological mechanisms linking SHPT and anemia in CKD are discussed. An efficient control of parathyroid hormone hypersecretion may be required to achieve a better management of anemia in HD patients.http://www.thieme-connect.de/DOI/DOI?10.4103/0974-2727.115935anemiachronic kidney diseaseferritinhemoglobinintact parathyroid hormonesecondary hyperparathyroidism |
| spellingShingle | Happy Chutia Alice Abraham Ruram Himashree Bhattacharyya Polina Boruah Chandan Nath Association of Secondary Hyperparathyroidism with Hemoglobin Level in Patients with Chronic Kidney Disease Journal of Laboratory Physicians anemia chronic kidney disease ferritin hemoglobin intact parathyroid hormone secondary hyperparathyroidism |
| title | Association of Secondary Hyperparathyroidism with Hemoglobin Level in Patients with Chronic Kidney Disease |
| title_full | Association of Secondary Hyperparathyroidism with Hemoglobin Level in Patients with Chronic Kidney Disease |
| title_fullStr | Association of Secondary Hyperparathyroidism with Hemoglobin Level in Patients with Chronic Kidney Disease |
| title_full_unstemmed | Association of Secondary Hyperparathyroidism with Hemoglobin Level in Patients with Chronic Kidney Disease |
| title_short | Association of Secondary Hyperparathyroidism with Hemoglobin Level in Patients with Chronic Kidney Disease |
| title_sort | association of secondary hyperparathyroidism with hemoglobin level in patients with chronic kidney disease |
| topic | anemia chronic kidney disease ferritin hemoglobin intact parathyroid hormone secondary hyperparathyroidism |
| url | http://www.thieme-connect.de/DOI/DOI?10.4103/0974-2727.115935 |
| work_keys_str_mv | AT happychutia associationofsecondaryhyperparathyroidismwithhemoglobinlevelinpatientswithchronickidneydisease AT aliceabrahamruram associationofsecondaryhyperparathyroidismwithhemoglobinlevelinpatientswithchronickidneydisease AT himashreebhattacharyya associationofsecondaryhyperparathyroidismwithhemoglobinlevelinpatientswithchronickidneydisease AT polinaboruah associationofsecondaryhyperparathyroidismwithhemoglobinlevelinpatientswithchronickidneydisease AT chandannath associationofsecondaryhyperparathyroidismwithhemoglobinlevelinpatientswithchronickidneydisease |