GLIS3 mediated by the Rap1/PI3K/AKT signal pathway facilitates real-ambient PM2.5 exposure disturbed thyroid hormone homeostasis regulation

GLIS3 mediated by the Rap1/PI3K/AKT signal pathway facilitates real-ambient PM2.5 exposure disturbed thyroid hormone homeostasis regulation

Exposure to fine particulate matter (PM2.5) could damage multiple organs and systems. Recent epidemiological studies have shown that PM2.5 can disrupt dynamic balance of thyroid hormone (TH). However, the underlying mechanism by which PM2.5 interferes with TH remains unclear. This study evaluated th...

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Bibliographic Details
Main Authors: Siying Tang, Daochuan Li, Hao Ding, Menghui Jiang, Yanjie Zhao, Dianke Yu, Rong Zhang, Wen Chen, Rui Chen, Yuxin Zheng, Jinmei Piao
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Ecotoxicology and Environmental Safety
Subjects:
PM2.5
Thyroid gland
GLIS3
Real-ambient PM exposure system
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651322000884

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