Relationships between Follicle-Stimulating Hormone and Adiponectin in Postmenopausal Women
Beyond fertility, follicle-stimulating hormone (FSH) may exert action on adipocytes, which are the major source of adiponectin and leptin, linking to insulin resistance. Therefore, we evaluated the relationships between FSH and adipocyte-derived hormones. This cross-sectional study enrolled postmeno...
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MDPI AG
2020-10-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/10/10/420 |
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| author | Wan-Yu Huang Dar-Ren Chen Chew-Teng Kor Ting-Yu Chen Po-Te Lin Joseph Ta Chien Tseng Hung-Ming Wu |
| author_facet | Wan-Yu Huang Dar-Ren Chen Chew-Teng Kor Ting-Yu Chen Po-Te Lin Joseph Ta Chien Tseng Hung-Ming Wu |
| author_sort | Wan-Yu Huang |
| collection | DOAJ |
| description | Beyond fertility, follicle-stimulating hormone (FSH) may exert action on adipocytes, which are the major source of adiponectin and leptin, linking to insulin resistance. Therefore, we evaluated the relationships between FSH and adipocyte-derived hormones. This cross-sectional study enrolled postmenopausal women aged 40–65 years. The variables measured in this study included clinical parameters, fasting levels of sex hormones, glucose, insulin, and adipokines. A total of 261 women without breast cancer, 88 women with breast cancer receiving tamoxifen, and 59 women with breast cancer receiving additional gonadotropin-releasing hormone analogs were enrolled in this study. Significant differences in the levels of adiponectin, leptin, and FSH were observed between the non-breast cancer group and the breast cancer groups. Spearman’s rank test revealed significant associations of FSH with either body mass index (BMI) or homeostatic model assessment of insulin resistance (HOMA-IR) values in the non-breast cancer group. After adjusting for BMI, age, and menopause duration, FSH levels were significantly associated with adiponectin (<i>p</i> < 0.001) and the leptin-to-adiponectin ratio (<i>p</i> = 0.008) in the non-breast cancer group, but they were only significantly associated with adiponectin (<i>p</i> = 0.001) in the breast cancer group receiving tamoxifen. Our data show that FSH levels are independently associated with adiponectin levels in postmenopausal women, suggesting that adiponectin may link FSH to metabolic relationships in postmenopausal female. |
| first_indexed | 2024-03-10T15:30:37Z |
| format | Article |
| id | doaj.art-75a0b2d7bd4b45c3905c435be9a6dbba |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-10T15:30:37Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-75a0b2d7bd4b45c3905c435be9a6dbba2023-11-20T17:40:04ZengMDPI AGMetabolites2218-19892020-10-01101042010.3390/metabo10100420Relationships between Follicle-Stimulating Hormone and Adiponectin in Postmenopausal WomenWan-Yu Huang0Dar-Ren Chen1Chew-Teng Kor2Ting-Yu Chen3Po-Te Lin4Joseph Ta Chien Tseng5Hung-Ming Wu6Pediatrics of Kung-Ten General Hospital, Taichung City 433, TaiwanComprehensive Breast Cancer Center, Changhua Christian Hospital, Changhua 500, TaiwanInternal Medicine Research Center, Changhua Christian Hospital, Changhua 500, TaiwanInflammation Research & Drug Development Center, Changhua Christian Hospital, Changhua 500, TaiwanInflammation Research & Drug Development Center, Changhua Christian Hospital, Changhua 500, TaiwanDepartment of Biotechnology and Bioindustry Sciences, National Cheng-Kung University, Tainan 701, TaiwanInflammation Research & Drug Development Center, Changhua Christian Hospital, Changhua 500, TaiwanBeyond fertility, follicle-stimulating hormone (FSH) may exert action on adipocytes, which are the major source of adiponectin and leptin, linking to insulin resistance. Therefore, we evaluated the relationships between FSH and adipocyte-derived hormones. This cross-sectional study enrolled postmenopausal women aged 40–65 years. The variables measured in this study included clinical parameters, fasting levels of sex hormones, glucose, insulin, and adipokines. A total of 261 women without breast cancer, 88 women with breast cancer receiving tamoxifen, and 59 women with breast cancer receiving additional gonadotropin-releasing hormone analogs were enrolled in this study. Significant differences in the levels of adiponectin, leptin, and FSH were observed between the non-breast cancer group and the breast cancer groups. Spearman’s rank test revealed significant associations of FSH with either body mass index (BMI) or homeostatic model assessment of insulin resistance (HOMA-IR) values in the non-breast cancer group. After adjusting for BMI, age, and menopause duration, FSH levels were significantly associated with adiponectin (<i>p</i> < 0.001) and the leptin-to-adiponectin ratio (<i>p</i> = 0.008) in the non-breast cancer group, but they were only significantly associated with adiponectin (<i>p</i> = 0.001) in the breast cancer group receiving tamoxifen. Our data show that FSH levels are independently associated with adiponectin levels in postmenopausal women, suggesting that adiponectin may link FSH to metabolic relationships in postmenopausal female.https://www.mdpi.com/2218-1989/10/10/420FSHadiponectininsulin resistancepostmenopauseand breast cancer |
| spellingShingle | Wan-Yu Huang Dar-Ren Chen Chew-Teng Kor Ting-Yu Chen Po-Te Lin Joseph Ta Chien Tseng Hung-Ming Wu Relationships between Follicle-Stimulating Hormone and Adiponectin in Postmenopausal Women Metabolites FSH adiponectin insulin resistance postmenopause and breast cancer |
| title | Relationships between Follicle-Stimulating Hormone and Adiponectin in Postmenopausal Women |
| title_full | Relationships between Follicle-Stimulating Hormone and Adiponectin in Postmenopausal Women |
| title_fullStr | Relationships between Follicle-Stimulating Hormone and Adiponectin in Postmenopausal Women |
| title_full_unstemmed | Relationships between Follicle-Stimulating Hormone and Adiponectin in Postmenopausal Women |
| title_short | Relationships between Follicle-Stimulating Hormone and Adiponectin in Postmenopausal Women |
| title_sort | relationships between follicle stimulating hormone and adiponectin in postmenopausal women |
| topic | FSH adiponectin insulin resistance postmenopause and breast cancer |
| url | https://www.mdpi.com/2218-1989/10/10/420 |
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