Low-dose combination of losartan, hydrochlorothiazide, and magnetic laser therapy: clinical effectiveness and quality of life impact
Aim. To study losartan effects, as monotherapy and in combination with hydrochlorothiazide (HCH) and magnetic laser therapy (МГТ), on 24-hour blood pressure (BPM) and quality of life (QoP) parameters in patients with mild to moderate arterial hypertension (AH).Material and methods. Bighty-three men...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
«SILICEA-POLIGRAF» LLC
2008-08-01
|
| Series: | Кардиоваскулярная терапия и профилактика |
| Subjects: | |
| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/1560 |
| _version_ | 1827064028685402112 |
|---|---|
| author | Kh. Z. Musieva A. N. Britov M. A. Umetov |
| author_facet | Kh. Z. Musieva A. N. Britov M. A. Umetov |
| author_sort | Kh. Z. Musieva |
| collection | DOAJ |
| description | Aim. To study losartan effects, as monotherapy and in combination with hydrochlorothiazide (HCH) and magnetic laser therapy (МГТ), on 24-hour blood pressure (BPM) and quality of life (QoP) parameters in patients with mild to moderate arterial hypertension (AH).Material and methods. Bighty-three men with mild to moderate AH were examined (mean age 51,4+5,6 years). At baseline and after 4 weeks of the treatment, 24-hour BPM and QoB parameters were measured in all participants.Results. After 4 weeks of the treatment, improved BP circadian rhythm (CR) was observed in all participants, especially in combined therapy groups. In the group of losartan, HCH and МГТ second 24-hour BPM demonstrated normalized BP CR, decreased prevalence of night CR type (from 39% to 25%), and reduced morning BP surge. Bosartan monotherapy, despite its good antihypertensive effect, did not result in BP CR normalization. Synergistic impact of combined pharmaceutical therapy and МГТ was observed in regard to antihypertensive effect and treatment tolerability Maximal changes in various Qor domains were registered among patients with initially low scores (73%); among participants with initially high scores (27%), Qor did not change significantly.Conclusion. Tosartan combination with HCH and МГТ was effective in AH patients, demonstrating not only good antihypertensive effect, but also Qor improvement. |
| first_indexed | 2024-04-10T03:39:32Z |
| format | Article |
| id | doaj.art-75a1299eb4e84885a08d37f03eecf65d |
| institution | Directory Open Access Journal |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| last_indexed | 2025-03-19T22:40:38Z |
| publishDate | 2008-08-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj.art-75a1299eb4e84885a08d37f03eecf65d2024-10-17T12:21:26Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252008-08-017478821277Low-dose combination of losartan, hydrochlorothiazide, and magnetic laser therapy: clinical effectiveness and quality of life impactKh. Z. Musieva0A. N. Britov1M. A. Umetov2Kabardino-Balkar State University. Nal’chikState Research Center for Preventive Medicine. MoscowKabardino-Balkar State University. Nal’chikAim. To study losartan effects, as monotherapy and in combination with hydrochlorothiazide (HCH) and magnetic laser therapy (МГТ), on 24-hour blood pressure (BPM) and quality of life (QoP) parameters in patients with mild to moderate arterial hypertension (AH).Material and methods. Bighty-three men with mild to moderate AH were examined (mean age 51,4+5,6 years). At baseline and after 4 weeks of the treatment, 24-hour BPM and QoB parameters were measured in all participants.Results. After 4 weeks of the treatment, improved BP circadian rhythm (CR) was observed in all participants, especially in combined therapy groups. In the group of losartan, HCH and МГТ second 24-hour BPM demonstrated normalized BP CR, decreased prevalence of night CR type (from 39% to 25%), and reduced morning BP surge. Bosartan monotherapy, despite its good antihypertensive effect, did not result in BP CR normalization. Synergistic impact of combined pharmaceutical therapy and МГТ was observed in regard to antihypertensive effect and treatment tolerability Maximal changes in various Qor domains were registered among patients with initially low scores (73%); among participants with initially high scores (27%), Qor did not change significantly.Conclusion. Tosartan combination with HCH and МГТ was effective in AH patients, demonstrating not only good antihypertensive effect, but also Qor improvement.https://cardiovascular.elpub.ru/jour/article/view/1560arterial hypertensionlosartanmagnetic laser24-hour blood pressure monitoringquality of life |
| spellingShingle | Kh. Z. Musieva A. N. Britov M. A. Umetov Low-dose combination of losartan, hydrochlorothiazide, and magnetic laser therapy: clinical effectiveness and quality of life impact Кардиоваскулярная терапия и профилактика arterial hypertension losartan magnetic laser 24-hour blood pressure monitoring quality of life |
| title | Low-dose combination of losartan, hydrochlorothiazide, and magnetic laser therapy: clinical effectiveness and quality of life impact |
| title_full | Low-dose combination of losartan, hydrochlorothiazide, and magnetic laser therapy: clinical effectiveness and quality of life impact |
| title_fullStr | Low-dose combination of losartan, hydrochlorothiazide, and magnetic laser therapy: clinical effectiveness and quality of life impact |
| title_full_unstemmed | Low-dose combination of losartan, hydrochlorothiazide, and magnetic laser therapy: clinical effectiveness and quality of life impact |
| title_short | Low-dose combination of losartan, hydrochlorothiazide, and magnetic laser therapy: clinical effectiveness and quality of life impact |
| title_sort | low dose combination of losartan hydrochlorothiazide and magnetic laser therapy clinical effectiveness and quality of life impact |
| topic | arterial hypertension losartan magnetic laser 24-hour blood pressure monitoring quality of life |
| url | https://cardiovascular.elpub.ru/jour/article/view/1560 |
| work_keys_str_mv | AT khzmusieva lowdosecombinationoflosartanhydrochlorothiazideandmagneticlasertherapyclinicaleffectivenessandqualityoflifeimpact AT anbritov lowdosecombinationoflosartanhydrochlorothiazideandmagneticlasertherapyclinicaleffectivenessandqualityoflifeimpact AT maumetov lowdosecombinationoflosartanhydrochlorothiazideandmagneticlasertherapyclinicaleffectivenessandqualityoflifeimpact |