Cancer Chemopreventive Role of Dietary Terpenoids by Modulating Keap1-Nrf2-ARE Signaling System—A Comprehensive Update
ROS, RNS, and carcinogenic metabolites generate excessive oxidative stress, which changes the basal cellular status and leads to epigenetic modification, genomic instability, and initiation of cancer. Epigenetic modification may inhibit tumor-suppressor genes and activate oncogenes, enabling cells t...
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| Formato: | Artigo |
| Idioma: | English |
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MDPI AG
2021-11-01
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| coleção: | Applied Sciences |
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| Acesso em linha: | https://www.mdpi.com/2076-3417/11/22/10806 |
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| author | Md Afjalus Siraj Md. Arman Islam Md. Abdullah Al Fahad Habiba Rahman Kheya Jianbo Xiao Jesus Simal-Gandara |
| author_facet | Md Afjalus Siraj Md. Arman Islam Md. Abdullah Al Fahad Habiba Rahman Kheya Jianbo Xiao Jesus Simal-Gandara |
| author_sort | Md Afjalus Siraj |
| collection | DOAJ |
| description | ROS, RNS, and carcinogenic metabolites generate excessive oxidative stress, which changes the basal cellular status and leads to epigenetic modification, genomic instability, and initiation of cancer. Epigenetic modification may inhibit tumor-suppressor genes and activate oncogenes, enabling cells to have cancer promoting properties. The nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that in humans is encoded by the NFE2L2 gene, and is activated in response to cellular stress. It can regulate redox homoeostasis by expressing several cytoprotective enzymes, including NADPH quinine oxidoreductase, heme oxygenase-1, UDP-glucuronosyltransferase, glutathione peroxidase, glutathione-S-transferase, etc. There is accumulating evidence supporting the idea that dietary nutraceuticals derived from commonly used fruits, vegetables, and spices have the ability to produce cancer chemopreventive activity by inducing Nrf2-mediated detoxifying enzymes. In this review, we discuss the importance of these nutraceuticals in cancer chemoprevention and summarize the role of dietary terpenoids in this respect. This approach was taken to accumulate the mechanistic function of these terpenoids to develop a comprehensive understanding of their direct and indirect roles in modulating the Keap1-Nrf2-ARE signaling system. |
| first_indexed | 2024-03-10T05:44:13Z |
| format | Article |
| id | doaj.art-75a12f1ee73c4ac8bc9e0f91fb75f2b4 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T05:44:13Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-75a12f1ee73c4ac8bc9e0f91fb75f2b42023-11-22T22:19:13ZengMDPI AGApplied Sciences2076-34172021-11-0111221080610.3390/app112210806Cancer Chemopreventive Role of Dietary Terpenoids by Modulating Keap1-Nrf2-ARE Signaling System—A Comprehensive UpdateMd Afjalus Siraj0Md. Arman Islam1Md. Abdullah Al Fahad2Habiba Rahman Kheya3Jianbo Xiao4Jesus Simal-Gandara5Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo, Hilo, HI 96720, USAPharmacy Discipline, Life Science School, Khulna University, Khulna 9208, BangladeshDepartment of Regenerative Medicine, College of Medicine, Soonchunhyang University, Cheonan 31151, KoreaDepartment of Sociology, Faculty of Social Sciences, University of Dhaka, Dhaka 1000, BangladeshNutrition and Bromatology Group, Department of Analytical and Food Chemistry, Faculty of Food Science and Technology, University of Vigo—Ourense Campus, E32004 Ourense, SpainNutrition and Bromatology Group, Department of Analytical and Food Chemistry, Faculty of Food Science and Technology, University of Vigo—Ourense Campus, E32004 Ourense, SpainROS, RNS, and carcinogenic metabolites generate excessive oxidative stress, which changes the basal cellular status and leads to epigenetic modification, genomic instability, and initiation of cancer. Epigenetic modification may inhibit tumor-suppressor genes and activate oncogenes, enabling cells to have cancer promoting properties. The nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that in humans is encoded by the NFE2L2 gene, and is activated in response to cellular stress. It can regulate redox homoeostasis by expressing several cytoprotective enzymes, including NADPH quinine oxidoreductase, heme oxygenase-1, UDP-glucuronosyltransferase, glutathione peroxidase, glutathione-S-transferase, etc. There is accumulating evidence supporting the idea that dietary nutraceuticals derived from commonly used fruits, vegetables, and spices have the ability to produce cancer chemopreventive activity by inducing Nrf2-mediated detoxifying enzymes. In this review, we discuss the importance of these nutraceuticals in cancer chemoprevention and summarize the role of dietary terpenoids in this respect. This approach was taken to accumulate the mechanistic function of these terpenoids to develop a comprehensive understanding of their direct and indirect roles in modulating the Keap1-Nrf2-ARE signaling system.https://www.mdpi.com/2076-3417/11/22/10806Keap1Nrf2AREterpenoidcancerchemoprevention |
| spellingShingle | Md Afjalus Siraj Md. Arman Islam Md. Abdullah Al Fahad Habiba Rahman Kheya Jianbo Xiao Jesus Simal-Gandara Cancer Chemopreventive Role of Dietary Terpenoids by Modulating Keap1-Nrf2-ARE Signaling System—A Comprehensive Update Applied Sciences Keap1 Nrf2 ARE terpenoid cancer chemoprevention |
| title | Cancer Chemopreventive Role of Dietary Terpenoids by Modulating Keap1-Nrf2-ARE Signaling System—A Comprehensive Update |
| title_full | Cancer Chemopreventive Role of Dietary Terpenoids by Modulating Keap1-Nrf2-ARE Signaling System—A Comprehensive Update |
| title_fullStr | Cancer Chemopreventive Role of Dietary Terpenoids by Modulating Keap1-Nrf2-ARE Signaling System—A Comprehensive Update |
| title_full_unstemmed | Cancer Chemopreventive Role of Dietary Terpenoids by Modulating Keap1-Nrf2-ARE Signaling System—A Comprehensive Update |
| title_short | Cancer Chemopreventive Role of Dietary Terpenoids by Modulating Keap1-Nrf2-ARE Signaling System—A Comprehensive Update |
| title_sort | cancer chemopreventive role of dietary terpenoids by modulating keap1 nrf2 are signaling system a comprehensive update |
| topic | Keap1 Nrf2 ARE terpenoid cancer chemoprevention |
| url | https://www.mdpi.com/2076-3417/11/22/10806 |
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