Cancer Chemopreventive Role of Dietary Terpenoids by Modulating Keap1-Nrf2-ARE Signaling System—A Comprehensive Update

Cancer Chemopreventive Role of Dietary Terpenoids by Modulating Keap1-Nrf2-ARE Signaling System—A Comprehensive Update

ROS, RNS, and carcinogenic metabolites generate excessive oxidative stress, which changes the basal cellular status and leads to epigenetic modification, genomic instability, and initiation of cancer. Epigenetic modification may inhibit tumor-suppressor genes and activate oncogenes, enabling cells t...

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Bibliographic Details
Main Authors: Md Afjalus Siraj, Md. Arman Islam, Md. Abdullah Al Fahad, Habiba Rahman Kheya, Jianbo Xiao, Jesus Simal-Gandara
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Applied Sciences
Subjects:
Keap1
Nrf2
ARE
terpenoid
cancer
chemoprevention
Online Access:https://www.mdpi.com/2076-3417/11/22/10806

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