Determinants of exposure to acrylamide in European children and adults based on urinary biomarkers: results from the “European Human Biomonitoring Initiative” HBM4EU participating studies
Abstract Little is known about exposure determinants of acrylamide (AA), a genotoxic food-processing contaminant, in Europe. We assessed determinants of AA exposure, measured by urinary mercapturic acids of AA (AAMA) and glycidamide (GAMA), its main metabolite, in 3157 children/adolescents and 1297...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-12-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-48738-6 |
| _version_ | 1797274514995806208 |
|---|---|
| author | Sandra F. Fernández Michael Poteser Eva Govarts Olga Pardo Clara Coscollà Thomas Schettgen Nina Vogel Till Weber Aline Murawski Marike Kolossa-Gehring Maria Rüther Phillipp Schmidt Sónia Namorado An Van Nieuwenhuyse Brice Appenzeller Kristín Ólafsdóttir Thorhallur I. Halldorsson Line S. Haug Cathrine Thomsen Fabio Barbone Marika Mariuz Valentina Rosolen Loïc Rambaud Margaux Riou Thomas Göen Stefanie Nübler Moritz Schäfer Karin H. A. Zarrabi Ovnair Sepai Laura Rodriguez Martin Greet Schoeters Liese Gilles Karin Leander Hanns Moshammer Agneta Akesson Federica Laguzzi |
| author_facet | Sandra F. Fernández Michael Poteser Eva Govarts Olga Pardo Clara Coscollà Thomas Schettgen Nina Vogel Till Weber Aline Murawski Marike Kolossa-Gehring Maria Rüther Phillipp Schmidt Sónia Namorado An Van Nieuwenhuyse Brice Appenzeller Kristín Ólafsdóttir Thorhallur I. Halldorsson Line S. Haug Cathrine Thomsen Fabio Barbone Marika Mariuz Valentina Rosolen Loïc Rambaud Margaux Riou Thomas Göen Stefanie Nübler Moritz Schäfer Karin H. A. Zarrabi Ovnair Sepai Laura Rodriguez Martin Greet Schoeters Liese Gilles Karin Leander Hanns Moshammer Agneta Akesson Federica Laguzzi |
| author_sort | Sandra F. Fernández |
| collection | DOAJ |
| description | Abstract Little is known about exposure determinants of acrylamide (AA), a genotoxic food-processing contaminant, in Europe. We assessed determinants of AA exposure, measured by urinary mercapturic acids of AA (AAMA) and glycidamide (GAMA), its main metabolite, in 3157 children/adolescents and 1297 adults in the European Human Biomonitoring Initiative. Harmonized individual-level questionnaires data and quality assured measurements of AAMA and GAMA (urine collection: 2014–2021), the short-term validated biomarkers of AA exposure, were obtained from four studies (Italy, France, Germany, and Norway) in children/adolescents (age range: 3–18 years) and six studies (Portugal, Spain, France, Germany, Luxembourg, and Iceland) in adults (age range: 20–45 years). Multivariable-adjusted pooled quantile regressions were employed to assess median differences (β coefficients) with 95% confidence intervals (95% CI) in AAMA and GAMA (µg/g creatinine) in relation to exposure determinants. Southern European studies had higher AAMA than Northern studies. In children/adolescents, we observed significant lower AA associated with high socioeconomic status (AAMA:β = − 9.1 µg/g creatinine, 95% CI − 15.8, − 2.4; GAMA: β = − 3.4 µg/g creatinine, 95% CI − 4.7, − 2.2), living in rural areas (AAMA:β = − 4.7 µg/g creatinine, 95% CI − 8.6, − 0.8; GAMA:β = − 1.1 µg/g creatinine, 95% CI − 1.9, − 0.4) and increasing age (AAMA:β = − 1.9 µg/g creatinine, 95% CI − 2.4, − 1.4; GAMA:β = − 0.7 µg/g creatinine, 95% CI − 0.8, − 0.6). In adults, higher AAMA was also associated with high consumption of fried potatoes whereas lower AAMA was associated with higher body-mass-index. Based on this large-scale study, several potential determinants of AA exposure were identified in children/adolescents and adults in European countries. |
| first_indexed | 2024-03-07T14:59:29Z |
| format | Article |
| id | doaj.art-75a266e0c08346808c78393b7d35977c |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T14:59:29Z |
| publishDate | 2023-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-75a266e0c08346808c78393b7d35977c2024-03-05T19:13:35ZengNature PortfolioScientific Reports2045-23222023-12-0113111110.1038/s41598-023-48738-6Determinants of exposure to acrylamide in European children and adults based on urinary biomarkers: results from the “European Human Biomonitoring Initiative” HBM4EU participating studiesSandra F. Fernández0Michael Poteser1Eva Govarts2Olga Pardo3Clara Coscollà4Thomas Schettgen5Nina Vogel6Till Weber7Aline Murawski8Marike Kolossa-Gehring9Maria Rüther10Phillipp Schmidt11Sónia Namorado12An Van Nieuwenhuyse13Brice Appenzeller14Kristín Ólafsdóttir15Thorhallur I. Halldorsson16Line S. Haug17Cathrine Thomsen18Fabio Barbone19Marika Mariuz20Valentina Rosolen21Loïc Rambaud22Margaux Riou23Thomas Göen24Stefanie Nübler25Moritz Schäfer26Karin H. A. Zarrabi27Ovnair Sepai28Laura Rodriguez Martin29Greet Schoeters30Liese Gilles31Karin Leander32Hanns Moshammer33Agneta Akesson34Federica Laguzzi35Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, FISABIO-Public HealthCenter for Public Health, Department of Environmental Health, Medical University of ViennaVITO Health, Flemish Institute for Technological Research (VITO)Public Health Directorate of ValenciaFoundation for the Promotion of Health and Biomedical Research in the Valencian Region, FISABIO-Public HealthInstitute for Occupational, Social and Environmental Medicine, Medical Faculty, RWTH Aachen UniversityGerman Environment Agency (UBA)German Environment Agency (UBA)German Environment Agency (UBA)German Environment Agency (UBA)German Environment Agency (UBA)German Environment Agency (UBA)Department of Epidemiology, National Institute of Health Doutor Ricardo JorgeLaboratoire National de Santé (LNS)Human Biomonitoring Research Unit, Department of Precision Health, Luxembourg Institute of Health (LIH)Department of Pharmacology and Toxicology, University of IcelandFaculty of Food Science and Nutrition, School of Health Sciences, University of IcelandNorwegian Institute of Public HealthNorwegian Institute of Public HealthDepartment of Medicine, Surgery and Health Sciences, University of Trieste, Ospedale di CattinaraCentral Directorate for Health, Social Policies and Disability, Friuli Venezia Giulia RegionCentral Directorate for Health, Social Policies and Disability, Friuli Venezia Giulia RegionSanté Publique France, SpFranceSanté Publique France, SpFranceInstitute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Friedrich-Alexander-Universität Erlangen-NürnbergInstitute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Friedrich-Alexander-Universität Erlangen-NürnbergInstitute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Friedrich-Alexander-Universität Erlangen-NürnbergInstitute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Friedrich-Alexander-Universität Erlangen-NürnbergUK Health Security AgencyVITO Health, Flemish Institute for Technological Research (VITO)VITO Health, Flemish Institute for Technological Research (VITO)VITO Health, Flemish Institute for Technological Research (VITO)Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska InstitutetCenter for Public Health, Department of Environmental Health, Medical University of ViennaUnit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska InstitutetUnit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska InstitutetAbstract Little is known about exposure determinants of acrylamide (AA), a genotoxic food-processing contaminant, in Europe. We assessed determinants of AA exposure, measured by urinary mercapturic acids of AA (AAMA) and glycidamide (GAMA), its main metabolite, in 3157 children/adolescents and 1297 adults in the European Human Biomonitoring Initiative. Harmonized individual-level questionnaires data and quality assured measurements of AAMA and GAMA (urine collection: 2014–2021), the short-term validated biomarkers of AA exposure, were obtained from four studies (Italy, France, Germany, and Norway) in children/adolescents (age range: 3–18 years) and six studies (Portugal, Spain, France, Germany, Luxembourg, and Iceland) in adults (age range: 20–45 years). Multivariable-adjusted pooled quantile regressions were employed to assess median differences (β coefficients) with 95% confidence intervals (95% CI) in AAMA and GAMA (µg/g creatinine) in relation to exposure determinants. Southern European studies had higher AAMA than Northern studies. In children/adolescents, we observed significant lower AA associated with high socioeconomic status (AAMA:β = − 9.1 µg/g creatinine, 95% CI − 15.8, − 2.4; GAMA: β = − 3.4 µg/g creatinine, 95% CI − 4.7, − 2.2), living in rural areas (AAMA:β = − 4.7 µg/g creatinine, 95% CI − 8.6, − 0.8; GAMA:β = − 1.1 µg/g creatinine, 95% CI − 1.9, − 0.4) and increasing age (AAMA:β = − 1.9 µg/g creatinine, 95% CI − 2.4, − 1.4; GAMA:β = − 0.7 µg/g creatinine, 95% CI − 0.8, − 0.6). In adults, higher AAMA was also associated with high consumption of fried potatoes whereas lower AAMA was associated with higher body-mass-index. Based on this large-scale study, several potential determinants of AA exposure were identified in children/adolescents and adults in European countries.https://doi.org/10.1038/s41598-023-48738-6 |
| spellingShingle | Sandra F. Fernández Michael Poteser Eva Govarts Olga Pardo Clara Coscollà Thomas Schettgen Nina Vogel Till Weber Aline Murawski Marike Kolossa-Gehring Maria Rüther Phillipp Schmidt Sónia Namorado An Van Nieuwenhuyse Brice Appenzeller Kristín Ólafsdóttir Thorhallur I. Halldorsson Line S. Haug Cathrine Thomsen Fabio Barbone Marika Mariuz Valentina Rosolen Loïc Rambaud Margaux Riou Thomas Göen Stefanie Nübler Moritz Schäfer Karin H. A. Zarrabi Ovnair Sepai Laura Rodriguez Martin Greet Schoeters Liese Gilles Karin Leander Hanns Moshammer Agneta Akesson Federica Laguzzi Determinants of exposure to acrylamide in European children and adults based on urinary biomarkers: results from the “European Human Biomonitoring Initiative” HBM4EU participating studies Scientific Reports |
| title | Determinants of exposure to acrylamide in European children and adults based on urinary biomarkers: results from the “European Human Biomonitoring Initiative” HBM4EU participating studies |
| title_full | Determinants of exposure to acrylamide in European children and adults based on urinary biomarkers: results from the “European Human Biomonitoring Initiative” HBM4EU participating studies |
| title_fullStr | Determinants of exposure to acrylamide in European children and adults based on urinary biomarkers: results from the “European Human Biomonitoring Initiative” HBM4EU participating studies |
| title_full_unstemmed | Determinants of exposure to acrylamide in European children and adults based on urinary biomarkers: results from the “European Human Biomonitoring Initiative” HBM4EU participating studies |
| title_short | Determinants of exposure to acrylamide in European children and adults based on urinary biomarkers: results from the “European Human Biomonitoring Initiative” HBM4EU participating studies |
| title_sort | determinants of exposure to acrylamide in european children and adults based on urinary biomarkers results from the european human biomonitoring initiative hbm4eu participating studies |
| url | https://doi.org/10.1038/s41598-023-48738-6 |
| work_keys_str_mv | AT sandraffernandez determinantsofexposuretoacrylamideineuropeanchildrenandadultsbasedonurinarybiomarkersresultsfromtheeuropeanhumanbiomonitoringinitiativehbm4euparticipatingstudies AT michaelpoteser determinantsofexposuretoacrylamideineuropeanchildrenandadultsbasedonurinarybiomarkersresultsfromtheeuropeanhumanbiomonitoringinitiativehbm4euparticipatingstudies AT evagovarts determinantsofexposuretoacrylamideineuropeanchildrenandadultsbasedonurinarybiomarkersresultsfromtheeuropeanhumanbiomonitoringinitiativehbm4euparticipatingstudies AT olgapardo determinantsofexposuretoacrylamideineuropeanchildrenandadultsbasedonurinarybiomarkersresultsfromtheeuropeanhumanbiomonitoringinitiativehbm4euparticipatingstudies AT claracoscolla determinantsofexposuretoacrylamideineuropeanchildrenandadultsbasedonurinarybiomarkersresultsfromtheeuropeanhumanbiomonitoringinitiativehbm4euparticipatingstudies AT thomasschettgen determinantsofexposuretoacrylamideineuropeanchildrenandadultsbasedonurinarybiomarkersresultsfromtheeuropeanhumanbiomonitoringinitiativehbm4euparticipatingstudies AT ninavogel determinantsofexposuretoacrylamideineuropeanchildrenandadultsbasedonurinarybiomarkersresultsfromtheeuropeanhumanbiomonitoringinitiativehbm4euparticipatingstudies AT tillweber determinantsofexposuretoacrylamideineuropeanchildrenandadultsbasedonurinarybiomarkersresultsfromtheeuropeanhumanbiomonitoringinitiativehbm4euparticipatingstudies AT alinemurawski determinantsofexposuretoacrylamideineuropeanchildrenandadultsbasedonurinarybiomarkersresultsfromtheeuropeanhumanbiomonitoringinitiativehbm4euparticipatingstudies AT marikekolossagehring determinantsofexposuretoacrylamideineuropeanchildrenandadultsbasedonurinarybiomarkersresultsfromtheeuropeanhumanbiomonitoringinitiativehbm4euparticipatingstudies AT mariaruther determinantsofexposuretoacrylamideineuropeanchildrenandadultsbasedonurinarybiomarkersresultsfromtheeuropeanhumanbiomonitoringinitiativehbm4euparticipatingstudies AT phillippschmidt determinantsofexposuretoacrylamideineuropeanchildrenandadultsbasedonurinarybiomarkersresultsfromtheeuropeanhumanbiomonitoringinitiativehbm4euparticipatingstudies AT sonianamorado determinantsofexposuretoacrylamideineuropeanchildrenandadultsbasedonurinarybiomarkersresultsfromtheeuropeanhumanbiomonitoringinitiativehbm4euparticipatingstudies AT anvannieuwenhuyse determinantsofexposuretoacrylamideineuropeanchildrenandadultsbasedonurinarybiomarkersresultsfromtheeuropeanhumanbiomonitoringinitiativehbm4euparticipatingstudies AT briceappenzeller determinantsofexposuretoacrylamideineuropeanchildrenandadultsbasedonurinarybiomarkersresultsfromtheeuropeanhumanbiomonitoringinitiativehbm4euparticipatingstudies AT kristinolafsdottir determinantsofexposuretoacrylamideineuropeanchildrenandadultsbasedonurinarybiomarkersresultsfromtheeuropeanhumanbiomonitoringinitiativehbm4euparticipatingstudies AT thorhallurihalldorsson determinantsofexposuretoacrylamideineuropeanchildrenandadultsbasedonurinarybiomarkersresultsfromtheeuropeanhumanbiomonitoringinitiativehbm4euparticipatingstudies AT lineshaug determinantsofexposuretoacrylamideineuropeanchildrenandadultsbasedonurinarybiomarkersresultsfromtheeuropeanhumanbiomonitoringinitiativehbm4euparticipatingstudies AT cathrinethomsen determinantsofexposuretoacrylamideineuropeanchildrenandadultsbasedonurinarybiomarkersresultsfromtheeuropeanhumanbiomonitoringinitiativehbm4euparticipatingstudies AT fabiobarbone determinantsofexposuretoacrylamideineuropeanchildrenandadultsbasedonurinarybiomarkersresultsfromtheeuropeanhumanbiomonitoringinitiativehbm4euparticipatingstudies AT marikamariuz determinantsofexposuretoacrylamideineuropeanchildrenandadultsbasedonurinarybiomarkersresultsfromtheeuropeanhumanbiomonitoringinitiativehbm4euparticipatingstudies AT valentinarosolen determinantsofexposuretoacrylamideineuropeanchildrenandadultsbasedonurinarybiomarkersresultsfromtheeuropeanhumanbiomonitoringinitiativehbm4euparticipatingstudies AT loicrambaud determinantsofexposuretoacrylamideineuropeanchildrenandadultsbasedonurinarybiomarkersresultsfromtheeuropeanhumanbiomonitoringinitiativehbm4euparticipatingstudies AT margauxriou determinantsofexposuretoacrylamideineuropeanchildrenandadultsbasedonurinarybiomarkersresultsfromtheeuropeanhumanbiomonitoringinitiativehbm4euparticipatingstudies AT thomasgoen determinantsofexposuretoacrylamideineuropeanchildrenandadultsbasedonurinarybiomarkersresultsfromtheeuropeanhumanbiomonitoringinitiativehbm4euparticipatingstudies AT stefanienubler determinantsofexposuretoacrylamideineuropeanchildrenandadultsbasedonurinarybiomarkersresultsfromtheeuropeanhumanbiomonitoringinitiativehbm4euparticipatingstudies AT moritzschafer determinantsofexposuretoacrylamideineuropeanchildrenandadultsbasedonurinarybiomarkersresultsfromtheeuropeanhumanbiomonitoringinitiativehbm4euparticipatingstudies AT karinhazarrabi determinantsofexposuretoacrylamideineuropeanchildrenandadultsbasedonurinarybiomarkersresultsfromtheeuropeanhumanbiomonitoringinitiativehbm4euparticipatingstudies AT ovnairsepai determinantsofexposuretoacrylamideineuropeanchildrenandadultsbasedonurinarybiomarkersresultsfromtheeuropeanhumanbiomonitoringinitiativehbm4euparticipatingstudies AT laurarodriguezmartin determinantsofexposuretoacrylamideineuropeanchildrenandadultsbasedonurinarybiomarkersresultsfromtheeuropeanhumanbiomonitoringinitiativehbm4euparticipatingstudies AT greetschoeters determinantsofexposuretoacrylamideineuropeanchildrenandadultsbasedonurinarybiomarkersresultsfromtheeuropeanhumanbiomonitoringinitiativehbm4euparticipatingstudies AT liesegilles determinantsofexposuretoacrylamideineuropeanchildrenandadultsbasedonurinarybiomarkersresultsfromtheeuropeanhumanbiomonitoringinitiativehbm4euparticipatingstudies AT karinleander determinantsofexposuretoacrylamideineuropeanchildrenandadultsbasedonurinarybiomarkersresultsfromtheeuropeanhumanbiomonitoringinitiativehbm4euparticipatingstudies AT hannsmoshammer determinantsofexposuretoacrylamideineuropeanchildrenandadultsbasedonurinarybiomarkersresultsfromtheeuropeanhumanbiomonitoringinitiativehbm4euparticipatingstudies AT agnetaakesson determinantsofexposuretoacrylamideineuropeanchildrenandadultsbasedonurinarybiomarkersresultsfromtheeuropeanhumanbiomonitoringinitiativehbm4euparticipatingstudies AT federicalaguzzi determinantsofexposuretoacrylamideineuropeanchildrenandadultsbasedonurinarybiomarkersresultsfromtheeuropeanhumanbiomonitoringinitiativehbm4euparticipatingstudies |