CAR T Cells Targeting Membrane-Bound Hsp70 on Tumor Cells Mimic Hsp70-Primed NK Cells

CAR T Cells Targeting Membrane-Bound Hsp70 on Tumor Cells Mimic Hsp70-Primed NK Cells

Strategies to boost anti-tumor immunity are urgently needed to treat therapy-resistant late-stage cancers, including colorectal cancers (CRCs). Cytokine stimulation and genetic modifications with chimeric antigen receptors (CAR) represent promising strategies to more specifically redirect anti-tumor...

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Bibliographic Details
Main Authors: Ali Bashiri Dezfouli, Mina Yazdi, Mohamed-Reda Benmebarek, Melissa Schwab, Stefanos Michaelides, Arianna Miccichè, Dirk Geerts, Stefan Stangl, Sarah Klapproth, Ernst Wagner, Sebastian Kobold, Gabriele Multhoff
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Immunology
Subjects:
adoptive Immunotherapy
Hsp70
IL-2
anti-Hsp70 CAR T cells
activated NK cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.883694/full

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