Epidemiologic, clinical and bacteriologic characteristics of pneumococcal meningitis in pediatric patients from Lima, Peru
Objectives. To describe the clinical characteristics, lethality, antibiotic susceptibility, and serotype distribution of pneumococcal meningitis in pediatric patients in Lima, Peru. Materials and Methods. A case series of pneumococcal meningitis in children less than 16 years of age from two prospec...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | Spanish |
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Instituto Nacional de Salud
2016-08-01
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| Series: | Revista Peruana de Medicina Experimental y Salud Pública |
| Subjects: | |
| Online Access: | https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/2349 |
| _version_ | 1819149911141122048 |
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| author | Long Davalos Yessica Terrazas Ana Quintana Martha Egoavil Katherine Sedano María E. Castillo Isabel Reyes Eduardo Chaparro Wilda Silva Francisco Campos Andrés Saenz Roger Hernandez Olguita del Águila Daniel Guillén Pinto Theresa J. Ochoa |
| author_facet | Long Davalos Yessica Terrazas Ana Quintana Martha Egoavil Katherine Sedano María E. Castillo Isabel Reyes Eduardo Chaparro Wilda Silva Francisco Campos Andrés Saenz Roger Hernandez Olguita del Águila Daniel Guillén Pinto Theresa J. Ochoa |
| author_sort | Long Davalos |
| collection | DOAJ |
| description | Objectives. To describe the clinical characteristics, lethality, antibiotic susceptibility, and serotype distribution of pneumococcal meningitis in pediatric patients in Lima, Peru. Materials and Methods. A case series of pneumococcal meningitis in children less than 16 years of age from two prospective, multicenter, passive surveillance studies of invasive pneumococcal diseases held in Lima-Peru from 2006 to 2008 and 2009 to 2011. Results. We report 44 pneumococcal meningitis episodes; 68.2% of them were in children less than 2 years old. The overall case fatality rate was 32.6%; 92.9% of fatal cases were in children less than 2 years of age (p0.05). Malnutrition was associated with fatal cases (p0.05). 64.3% of fatal cases died within the first two days. 41.9% of pneumococcal isolates were resistant to penicillin, 23.3% were intermediate resistant to ceftriaxone (none were highly resistant) and 9.3% were resistant to chloramphenicol. The most common serotypes were 6B, 14, 19F and 23F, which accounted for 68.3% of all strains; 84.1% of strains were PCV13 serotypes. Conclusions. Pneumococcal meningitis continues to be a lethal disease, especially in children less than 2 years of age. Since almost two third of lethal cases lead to death within the first 48 hours, prompt diagnosis and management is critical, as well as assurance of immunization with pneumococcal vaccine. |
| first_indexed | 2024-12-22T14:09:07Z |
| format | Article |
| id | doaj.art-75a3dfe7c38a48af9c0a13bb707813fd |
| institution | Directory Open Access Journal |
| issn | 1726-4634 1726-4642 |
| language | Spanish |
| last_indexed | 2024-12-22T14:09:07Z |
| publishDate | 2016-08-01 |
| publisher | Instituto Nacional de Salud |
| record_format | Article |
| series | Revista Peruana de Medicina Experimental y Salud Pública |
| spelling | doaj.art-75a3dfe7c38a48af9c0a13bb707813fd2022-12-21T18:23:14ZspaInstituto Nacional de SaludRevista Peruana de Medicina Experimental y Salud Pública1726-46341726-46422016-08-013334253110.17843/rpmesp.2016.333.23491803Epidemiologic, clinical and bacteriologic characteristics of pneumococcal meningitis in pediatric patients from Lima, PeruLong Davalos0Yessica Terrazas1Ana Quintana2Martha Egoavil3Katherine Sedano4María E. Castillo5Isabel Reyes6Eduardo Chaparro7Wilda Silva8Francisco Campos9Andrés Saenz10Roger Hernandez11Olguita del Águila12Daniel Guillén Pinto13Theresa J. Ochoa14Universidad Peruana Cayetano Heredia. Lima, Perú. Médico cirujanoUniversidad Peruana Cayetano Heredia. Lima, Perú. Hospital Nacional Cayetano Heredia. Lima, Perú. Médico cirujanoUniversidad Peruana Cayetano Heredia. Lima, Perú. Hospital Nacional Cayetano Heredia. Lima, Perú. Médico cirujanoUniversidad Peruana Cayetano Heredia. Lima, Perú. Médico cirujanoUniversidad Peruana Cayetano Heredia. Lima, Perú. Hospital Nacional Cayetano Heredia. Lima, Perú. Médico cirujanoUniversidad Peruana Cayetano Heredia. Lima, Perú. Instituto Nacional de Salud del Niño. Lima, Perú. médico infectólogo pediatraHospital de Emergencias Pediátricas. Lima, Perú. Médico cirujanoUniversidad Peruana Cayetano Heredia. Lima, Perú. Hospital Nacional Cayetano Heredia. Lima, Perú. médico infectólogo pediatraHospital Nacional Edgardo Rebagliati Martins. Lima, Perú. médico infectólogo pediatraHospital Nacional Docente Madre-Niño San Bartolomé. Lima, Perú. médico infectólogo pediatraHospital Daniel A. Carrión. Lima, Perú. médico infectólogo pediatraUniversidad Peruana Cayetano Heredia. Lima, Perú. Hospital Nacional Cayetano Heredia. Lima, Perú. médico infectólogo pediatraHospital Nacional Edgardo Rebagliati Martins. Lima, Perú. médico infectólogo pediatraUniversidad Peruana Cayetano Heredia. Lima, Perú. Hospital Nacional Cayetano Heredia. Lima, Perú. médico neurólogo pediatraUniversidad Peruana Cayetano Heredia. Lima, Perú. University of Texas School of Public Health. Houston, Texas, United States of America. médico infectólogo pediatraObjectives. To describe the clinical characteristics, lethality, antibiotic susceptibility, and serotype distribution of pneumococcal meningitis in pediatric patients in Lima, Peru. Materials and Methods. A case series of pneumococcal meningitis in children less than 16 years of age from two prospective, multicenter, passive surveillance studies of invasive pneumococcal diseases held in Lima-Peru from 2006 to 2008 and 2009 to 2011. Results. We report 44 pneumococcal meningitis episodes; 68.2% of them were in children less than 2 years old. The overall case fatality rate was 32.6%; 92.9% of fatal cases were in children less than 2 years of age (p0.05). Malnutrition was associated with fatal cases (p0.05). 64.3% of fatal cases died within the first two days. 41.9% of pneumococcal isolates were resistant to penicillin, 23.3% were intermediate resistant to ceftriaxone (none were highly resistant) and 9.3% were resistant to chloramphenicol. The most common serotypes were 6B, 14, 19F and 23F, which accounted for 68.3% of all strains; 84.1% of strains were PCV13 serotypes. Conclusions. Pneumococcal meningitis continues to be a lethal disease, especially in children less than 2 years of age. Since almost two third of lethal cases lead to death within the first 48 hours, prompt diagnosis and management is critical, as well as assurance of immunization with pneumococcal vaccine.https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/2349streptococcus pneumoniaemeningitis neumocócicaperúmortalidad infantil |
| spellingShingle | Long Davalos Yessica Terrazas Ana Quintana Martha Egoavil Katherine Sedano María E. Castillo Isabel Reyes Eduardo Chaparro Wilda Silva Francisco Campos Andrés Saenz Roger Hernandez Olguita del Águila Daniel Guillén Pinto Theresa J. Ochoa Epidemiologic, clinical and bacteriologic characteristics of pneumococcal meningitis in pediatric patients from Lima, Peru Revista Peruana de Medicina Experimental y Salud Pública streptococcus pneumoniae meningitis neumocócica perú mortalidad infantil |
| title | Epidemiologic, clinical and bacteriologic characteristics of pneumococcal meningitis in pediatric patients from Lima, Peru |
| title_full | Epidemiologic, clinical and bacteriologic characteristics of pneumococcal meningitis in pediatric patients from Lima, Peru |
| title_fullStr | Epidemiologic, clinical and bacteriologic characteristics of pneumococcal meningitis in pediatric patients from Lima, Peru |
| title_full_unstemmed | Epidemiologic, clinical and bacteriologic characteristics of pneumococcal meningitis in pediatric patients from Lima, Peru |
| title_short | Epidemiologic, clinical and bacteriologic characteristics of pneumococcal meningitis in pediatric patients from Lima, Peru |
| title_sort | epidemiologic clinical and bacteriologic characteristics of pneumococcal meningitis in pediatric patients from lima peru |
| topic | streptococcus pneumoniae meningitis neumocócica perú mortalidad infantil |
| url | https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/2349 |
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