Amelioration of Hippocampal Insulin Resistance Reduces Tau Hyperphosphorylation and Cognitive Decline Induced by Isoflurane in Mice

Amelioration of Hippocampal Insulin Resistance Reduces Tau Hyperphosphorylation and Cognitive Decline Induced by Isoflurane in Mice

General anesthetics can induce cognitive impairments and increase the risk of Alzheimer’s disease (AD). However, the underlying mechanisms are still unknown. Our previous studies shown that long-term isoflurane exposure induced peripheral and central insulin resistance (IR) in adult mice and aggrava...

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Bibliographic Details
Main Authors: Liangyu Peng, Xin Fang, Fangxia Xu, Shuai Liu, Yue Qian, Xiangdan Gong, Xin Zhao, Zhengliang Ma, Tianjiao Xia, Xiaoping Gu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Aging Neuroscience
Subjects:
cognitive impairment
isoflurane
insulin resistance
metformin
hippocampus
blood glucose
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.686506/full

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