The Role of microRNAs in Epigenetic Regulation of Signaling Pathways in Neurological Pathologies
In recent times, there has been a significant increase in researchers’ interest in the functions of microRNAs and the role of these molecules in the pathogenesis of many multifactorial diseases. This is related to the diagnostic and prognostic potential of microRNA expression levels as well as the p...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/16/12899 |
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| author | Pavel P. Tregub Irada Ibrahimli Anton S. Averchuk Alla B. Salmina Peter F. Litvitskiy Zaripat Sh. Manasova Inga A. Popova |
| author_facet | Pavel P. Tregub Irada Ibrahimli Anton S. Averchuk Alla B. Salmina Peter F. Litvitskiy Zaripat Sh. Manasova Inga A. Popova |
| author_sort | Pavel P. Tregub |
| collection | DOAJ |
| description | In recent times, there has been a significant increase in researchers’ interest in the functions of microRNAs and the role of these molecules in the pathogenesis of many multifactorial diseases. This is related to the diagnostic and prognostic potential of microRNA expression levels as well as the prospects of using it in personalized targeted therapy. This review of the literature analyzes existing scientific data on the involvement of microRNAs in the molecular and cellular mechanisms underlying the development of pathologies such as Alzheimer’s disease, cerebral ischemia and reperfusion injury, and dysfunction of the blood–brain barrier. |
| first_indexed | 2024-03-10T23:52:25Z |
| format | Article |
| id | doaj.art-75a8ba70a27e45ceb1c945e5259b3f56 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T23:52:25Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-75a8ba70a27e45ceb1c945e5259b3f562023-11-19T01:31:46ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-08-0124161289910.3390/ijms241612899The Role of microRNAs in Epigenetic Regulation of Signaling Pathways in Neurological PathologiesPavel P. Tregub0Irada Ibrahimli1Anton S. Averchuk2Alla B. Salmina3Peter F. Litvitskiy4Zaripat Sh. Manasova5Inga A. Popova6Department of Pathophysiology, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, RussiaDepartment of Pathophysiology, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, RussiaResearch Center of Neurology, 125367 Moscow, RussiaResearch Center of Neurology, 125367 Moscow, RussiaDepartment of Pathophysiology, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, RussiaDepartment of Pathophysiology, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, RussiaDepartment of Pathophysiology, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, RussiaIn recent times, there has been a significant increase in researchers’ interest in the functions of microRNAs and the role of these molecules in the pathogenesis of many multifactorial diseases. This is related to the diagnostic and prognostic potential of microRNA expression levels as well as the prospects of using it in personalized targeted therapy. This review of the literature analyzes existing scientific data on the involvement of microRNAs in the molecular and cellular mechanisms underlying the development of pathologies such as Alzheimer’s disease, cerebral ischemia and reperfusion injury, and dysfunction of the blood–brain barrier.https://www.mdpi.com/1422-0067/24/16/12899miRNAAlzheimer’s diseaseischemia–reperfusion injuryblood–brain barrierRNA biologyneuroinflammation |
| spellingShingle | Pavel P. Tregub Irada Ibrahimli Anton S. Averchuk Alla B. Salmina Peter F. Litvitskiy Zaripat Sh. Manasova Inga A. Popova The Role of microRNAs in Epigenetic Regulation of Signaling Pathways in Neurological Pathologies International Journal of Molecular Sciences miRNA Alzheimer’s disease ischemia–reperfusion injury blood–brain barrier RNA biology neuroinflammation |
| title | The Role of microRNAs in Epigenetic Regulation of Signaling Pathways in Neurological Pathologies |
| title_full | The Role of microRNAs in Epigenetic Regulation of Signaling Pathways in Neurological Pathologies |
| title_fullStr | The Role of microRNAs in Epigenetic Regulation of Signaling Pathways in Neurological Pathologies |
| title_full_unstemmed | The Role of microRNAs in Epigenetic Regulation of Signaling Pathways in Neurological Pathologies |
| title_short | The Role of microRNAs in Epigenetic Regulation of Signaling Pathways in Neurological Pathologies |
| title_sort | role of micrornas in epigenetic regulation of signaling pathways in neurological pathologies |
| topic | miRNA Alzheimer’s disease ischemia–reperfusion injury blood–brain barrier RNA biology neuroinflammation |
| url | https://www.mdpi.com/1422-0067/24/16/12899 |
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