Downregulation of the long noncoding RNA MBNL1-AS1 protects sevoflurane-pretreated mice against ischemia-reperfusion injury by targeting KCNMA1
Osteoarthritis: Limiting tissue damage after knee surgery A potential therapeutic target identified by researchers in China could help limit damage to tissues following osteoarthritic knee surgery. A total knee arthroplasty can alleviate symptoms of end-stage osteoarthritis, but the surgery requires...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2018-09-01
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| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-018-0133-y |
| _version_ | 1818875563987697664 |
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| author | Xue-Feng Li Zong-Qiang Wang Long-Yun Li Guo-Qing Zhao Shao-Nan Yu |
| author_facet | Xue-Feng Li Zong-Qiang Wang Long-Yun Li Guo-Qing Zhao Shao-Nan Yu |
| author_sort | Xue-Feng Li |
| collection | DOAJ |
| description | Osteoarthritis: Limiting tissue damage after knee surgery A potential therapeutic target identified by researchers in China could help limit damage to tissues following osteoarthritic knee surgery. A total knee arthroplasty can alleviate symptoms of end-stage osteoarthritis, but the surgery requires use of a tourniquet. This temporarily cuts blood supply to tissues and can trigger severe ischemia-reperfusion (I/R) injury, tissue damage caused by blood flow returning after oxygen deficiency. Shao-Nan Yu and co-workers at the China-Japan Union Hospital of Jilin University, Changchun, demonstrated that lowering expression of a particular RNA molecule following surgery could limit I/R damage. They found that the molecule was over-expressed in mice during I/R injury. This overexpression limited activation of a signalling pathway and an associated protein vital to the chemical balance of cell membranes and healthy muscle cell contraction. |
| first_indexed | 2024-12-19T13:28:30Z |
| format | Article |
| id | doaj.art-75a9bf25171a4477a77b125f2624f365 |
| institution | Directory Open Access Journal |
| issn | 2092-6413 |
| language | English |
| last_indexed | 2024-12-19T13:28:30Z |
| publishDate | 2018-09-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Experimental and Molecular Medicine |
| spelling | doaj.art-75a9bf25171a4477a77b125f2624f3652022-12-21T20:19:28ZengNature Publishing GroupExperimental and Molecular Medicine2092-64132018-09-0150911610.1038/s12276-018-0133-yDownregulation of the long noncoding RNA MBNL1-AS1 protects sevoflurane-pretreated mice against ischemia-reperfusion injury by targeting KCNMA1Xue-Feng Li0Zong-Qiang Wang1Long-Yun Li2Guo-Qing Zhao3Shao-Nan Yu4Department of Anesthesiology, China-Japan Union Hospital of Jilin UniversityMedical Department, China-Japan Union Hospital of Jilin UniversityDepartment of Anesthesiology, China-Japan Union Hospital of Jilin UniversityDepartment of Anesthesiology, China-Japan Union Hospital of Jilin UniversityDepartment of Radiology, China-Japan Union Hospital of Jilin UniversityOsteoarthritis: Limiting tissue damage after knee surgery A potential therapeutic target identified by researchers in China could help limit damage to tissues following osteoarthritic knee surgery. A total knee arthroplasty can alleviate symptoms of end-stage osteoarthritis, but the surgery requires use of a tourniquet. This temporarily cuts blood supply to tissues and can trigger severe ischemia-reperfusion (I/R) injury, tissue damage caused by blood flow returning after oxygen deficiency. Shao-Nan Yu and co-workers at the China-Japan Union Hospital of Jilin University, Changchun, demonstrated that lowering expression of a particular RNA molecule following surgery could limit I/R damage. They found that the molecule was over-expressed in mice during I/R injury. This overexpression limited activation of a signalling pathway and an associated protein vital to the chemical balance of cell membranes and healthy muscle cell contraction.https://doi.org/10.1038/s12276-018-0133-y |
| spellingShingle | Xue-Feng Li Zong-Qiang Wang Long-Yun Li Guo-Qing Zhao Shao-Nan Yu Downregulation of the long noncoding RNA MBNL1-AS1 protects sevoflurane-pretreated mice against ischemia-reperfusion injury by targeting KCNMA1 Experimental and Molecular Medicine |
| title | Downregulation of the long noncoding RNA MBNL1-AS1 protects sevoflurane-pretreated mice against ischemia-reperfusion injury by targeting KCNMA1 |
| title_full | Downregulation of the long noncoding RNA MBNL1-AS1 protects sevoflurane-pretreated mice against ischemia-reperfusion injury by targeting KCNMA1 |
| title_fullStr | Downregulation of the long noncoding RNA MBNL1-AS1 protects sevoflurane-pretreated mice against ischemia-reperfusion injury by targeting KCNMA1 |
| title_full_unstemmed | Downregulation of the long noncoding RNA MBNL1-AS1 protects sevoflurane-pretreated mice against ischemia-reperfusion injury by targeting KCNMA1 |
| title_short | Downregulation of the long noncoding RNA MBNL1-AS1 protects sevoflurane-pretreated mice against ischemia-reperfusion injury by targeting KCNMA1 |
| title_sort | downregulation of the long noncoding rna mbnl1 as1 protects sevoflurane pretreated mice against ischemia reperfusion injury by targeting kcnma1 |
| url | https://doi.org/10.1038/s12276-018-0133-y |
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