PKCθ links proximal T cell and Notch signaling through localized regulation of the actin cytoskeleton

PKCθ links proximal T cell and Notch signaling through localized regulation of the actin cytoskeleton

Notch is a critical regulator of T cell differentiation and is activated through proteolytic cleavage in response to ligand engagement. Using murine myelin-reactive CD4 T cells, we demonstrate that proximal T cell signaling modulates Notch activation by a spatiotemporally constrained mechanism. The...

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Bibliographic Details
Main Authors: Graham J Britton, Rachel Ambler, Danielle J Clark, Elaine V Hill, Helen M Tunbridge, Kerrie E McNally, Bronwen R Burton, Philomena Butterweck, Catherine Sabatos-Peyton, Lea A Hampton-O’Neil, Paul Verkade, Christoph Wülfing, David Cameron Wraith
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-01-01
Series:eLife
Subjects:
CD4 T cell
cell signalling
cytoskeleton
Online Access:https://elifesciences.org/articles/20003

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