5-aminolevulinic acid photodynamic therapy for condyloma acuminatum of urethral meatus
Objectives: Condyloma acuminatum are the most common sexually transmitted diseases worldwide, and they are closely associated with human papillomavirus (HPV) infection. Urethral meatus is one of the places that warts occur. Many treatments for uretheral warts have limitations. In this study, we perf...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-10-01
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| Series: | Journal of Dermatological Treatment |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09546634.2018.1544406 |
| _version_ | 1797683695601057792 |
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| author | Jiajia Xie Chunping Ao Junpeng Li Lifen Jiang Hui Liu Kang Zeng |
| author_facet | Jiajia Xie Chunping Ao Junpeng Li Lifen Jiang Hui Liu Kang Zeng |
| author_sort | Jiajia Xie |
| collection | DOAJ |
| description | Objectives: Condyloma acuminatum are the most common sexually transmitted diseases worldwide, and they are closely associated with human papillomavirus (HPV) infection. Urethral meatus is one of the places that warts occur. Many treatments for uretheral warts have limitations. In this study, we performed 5-aminolevulinic acid-photodynamic therapy (ALA-PDT) on patients and investigated the effectiveness of reducing HPV viral loads. Materials and Methods: In our study, 21 patients diagnosed with urethral condyloma acuminatum were included. After 4 h treatment of ALA, patients received PDT. Each patient received HPV test before every PDT cycle. The frequency of PDT was dependent on viral load changes. Results: All patients achieved complete clinical remission after the last session of ALA-PDT. There were significant differences in HPV viral loads between pretherapy and after one or three rounds of PDT treatment. Conclusions: ALA-PDT is a safe and effective method for treatment of condyloma acuminatum in urethra meatus. Dynamic monitoring of HPV viral loads can more objectively demonstrate the effectiveness and guide the treatment of PDT. |
| first_indexed | 2024-03-12T00:18:10Z |
| format | Article |
| id | doaj.art-75b29379c0fb46d1a1800e63c2227e7e |
| institution | Directory Open Access Journal |
| issn | 0954-6634 1471-1753 |
| language | English |
| last_indexed | 2024-03-12T00:18:10Z |
| publishDate | 2019-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj.art-75b29379c0fb46d1a1800e63c2227e7e2023-09-15T14:08:34ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532019-10-0130771471710.1080/09546634.2018.154440615444065-aminolevulinic acid photodynamic therapy for condyloma acuminatum of urethral meatusJiajia Xie0Chunping Ao1Junpeng Li2Lifen Jiang3Hui Liu4Kang Zeng5Nanfang Hospital, Southern Medical UniversityNanfang Hospital, Southern Medical UniversityNanfang Hospital, Southern Medical UniversityNanfang Hospital, Southern Medical UniversityNanfang Hospital, Southern Medical UniversityNanfang Hospital, Southern Medical UniversityObjectives: Condyloma acuminatum are the most common sexually transmitted diseases worldwide, and they are closely associated with human papillomavirus (HPV) infection. Urethral meatus is one of the places that warts occur. Many treatments for uretheral warts have limitations. In this study, we performed 5-aminolevulinic acid-photodynamic therapy (ALA-PDT) on patients and investigated the effectiveness of reducing HPV viral loads. Materials and Methods: In our study, 21 patients diagnosed with urethral condyloma acuminatum were included. After 4 h treatment of ALA, patients received PDT. Each patient received HPV test before every PDT cycle. The frequency of PDT was dependent on viral load changes. Results: All patients achieved complete clinical remission after the last session of ALA-PDT. There were significant differences in HPV viral loads between pretherapy and after one or three rounds of PDT treatment. Conclusions: ALA-PDT is a safe and effective method for treatment of condyloma acuminatum in urethra meatus. Dynamic monitoring of HPV viral loads can more objectively demonstrate the effectiveness and guide the treatment of PDT.http://dx.doi.org/10.1080/09546634.2018.1544406urethral meatuscondyloma acuminatumala-pdthpv |
| spellingShingle | Jiajia Xie Chunping Ao Junpeng Li Lifen Jiang Hui Liu Kang Zeng 5-aminolevulinic acid photodynamic therapy for condyloma acuminatum of urethral meatus Journal of Dermatological Treatment urethral meatus condyloma acuminatum ala-pdt hpv |
| title | 5-aminolevulinic acid photodynamic therapy for condyloma acuminatum of urethral meatus |
| title_full | 5-aminolevulinic acid photodynamic therapy for condyloma acuminatum of urethral meatus |
| title_fullStr | 5-aminolevulinic acid photodynamic therapy for condyloma acuminatum of urethral meatus |
| title_full_unstemmed | 5-aminolevulinic acid photodynamic therapy for condyloma acuminatum of urethral meatus |
| title_short | 5-aminolevulinic acid photodynamic therapy for condyloma acuminatum of urethral meatus |
| title_sort | 5 aminolevulinic acid photodynamic therapy for condyloma acuminatum of urethral meatus |
| topic | urethral meatus condyloma acuminatum ala-pdt hpv |
| url | http://dx.doi.org/10.1080/09546634.2018.1544406 |
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