Therapeutic Potential of a Novel Vitamin D<sub>3</sub> Oxime Analogue, VD1-6, with CYP24A1 Enzyme Inhibitory Activity and Negligible Vitamin D Receptor Binding

Therapeutic Potential of a Novel Vitamin D<sub>3</sub> Oxime Analogue, VD1-6, with CYP24A1 Enzyme Inhibitory Activity and Negligible Vitamin D Receptor Binding

The regulation of vitamin D<sub>3</sub> actions in humans occurs mainly through the Cytochrome P450 24-hydroxylase (CYP24A1) enzyme activity. CYP24A1 hydroxylates both 25-hydroxycholecalciferol (25(OH)D<sub>3</sub>) and 1,25-dihydroxycholecalciferol (1,25(OH)<sub>2</...

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Bibliographic Details
Main Authors: Ali K. Alshabrawy, Yingjie Cui, Cyan Sylvester, Dongqing Yang, Emilio S. Petito, Kate R. Barratt, Rebecca K. Sawyer, Jessica K. Heatlie, Ruhi Polara, Matthew J. Sykes, Gerald J. Atkins, Shane M. Hickey, Michael D. Wiese, Andrea M. Stringer, Zhaopeng Liu, Paul H. Anderson
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Biomolecules
Subjects:
vitamin D<sub>3</sub>
CYP24A1
in silico docking
catabolism inhibition
HEK293T
Online Access:https://www.mdpi.com/2218-273X/12/7/960

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