Latent class analysis of multimorbidity patterns and associated outcomes in Spanish older adults: a prospective cohort study
Abstract Background This study sought to identify multimorbidity patterns and determine the association between these latent classes with several outcomes, including health, functioning, disability, quality of life and use of services, at baseline and after 3 years of follow-up. Methods We analyzed...
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| Format: | Article |
| Language: | English |
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BMC
2017-08-01
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| Series: | BMC Geriatrics |
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| Online Access: | http://link.springer.com/article/10.1186/s12877-017-0586-1 |
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| author | Beatriz Olaya Maria Victoria Moneta Francisco Félix Caballero Stefanos Tyrovolas Ivet Bayes José Luis Ayuso-Mateos Josep Maria Haro |
| author_facet | Beatriz Olaya Maria Victoria Moneta Francisco Félix Caballero Stefanos Tyrovolas Ivet Bayes José Luis Ayuso-Mateos Josep Maria Haro |
| author_sort | Beatriz Olaya |
| collection | DOAJ |
| description | Abstract Background This study sought to identify multimorbidity patterns and determine the association between these latent classes with several outcomes, including health, functioning, disability, quality of life and use of services, at baseline and after 3 years of follow-up. Methods We analyzed data from a representative Spanish cohort of 3541 non-institutionalized people aged 50 years old and over. Measures were taken at baseline and after 3 years of follow-up. Latent Class Analysis (LCA) was conducted using eleven common chronic conditions. Generalized linear models were conducted to determine the adjusted association of multimorbidity latent classes with several outcomes. Results 63.8% of participants were assigned to the “healthy” class, with minimum disease, 30% were classified under the “metabolic/stroke” class and 6% were assigned to the “cardiorespiratory/mental/arthritis” class. Significant cross-sectional associations were found between membership of both multimorbidity classes and poorer memory, quality of life, greater burden and more use of services. After 3 years of follow-up, the “metabolic/stroke” class was a significant predictor of lower levels of verbal fluency while the two multimorbidity classes predicted poor quality of life, problems in independent living, higher risk of hospitalization and greater use of health services. Conclusions Common chronic conditions in older people cluster together in broad categories. These broad clusters are qualitatively distinct and are important predictors of several health and functioning outcomes. Future studies are needed to understand underlying mechanisms and common risk factors for patterns of multimorbidity and to propose more effective treatments. |
| first_indexed | 2024-12-14T09:50:26Z |
| format | Article |
| id | doaj.art-75b2ebbc234d484b886c56daf1830540 |
| institution | Directory Open Access Journal |
| issn | 1471-2318 |
| language | English |
| last_indexed | 2024-12-14T09:50:26Z |
| publishDate | 2017-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Geriatrics |
| spelling | doaj.art-75b2ebbc234d484b886c56daf18305402022-12-21T23:07:32ZengBMCBMC Geriatrics1471-23182017-08-0117111010.1186/s12877-017-0586-1Latent class analysis of multimorbidity patterns and associated outcomes in Spanish older adults: a prospective cohort studyBeatriz Olaya0Maria Victoria Moneta1Francisco Félix Caballero2Stefanos Tyrovolas3Ivet Bayes4José Luis Ayuso-Mateos5Josep Maria Haro6Research, Innovation and Teaching Unit, Institut de Recerca Sant Joan de DéuResearch, Innovation and Teaching Unit, Institut de Recerca Sant Joan de DéuInstituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM)Research, Innovation and Teaching Unit, Institut de Recerca Sant Joan de DéuResearch, Innovation and Teaching Unit, Institut de Recerca Sant Joan de DéuInstituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM)Research, Innovation and Teaching Unit, Institut de Recerca Sant Joan de DéuAbstract Background This study sought to identify multimorbidity patterns and determine the association between these latent classes with several outcomes, including health, functioning, disability, quality of life and use of services, at baseline and after 3 years of follow-up. Methods We analyzed data from a representative Spanish cohort of 3541 non-institutionalized people aged 50 years old and over. Measures were taken at baseline and after 3 years of follow-up. Latent Class Analysis (LCA) was conducted using eleven common chronic conditions. Generalized linear models were conducted to determine the adjusted association of multimorbidity latent classes with several outcomes. Results 63.8% of participants were assigned to the “healthy” class, with minimum disease, 30% were classified under the “metabolic/stroke” class and 6% were assigned to the “cardiorespiratory/mental/arthritis” class. Significant cross-sectional associations were found between membership of both multimorbidity classes and poorer memory, quality of life, greater burden and more use of services. After 3 years of follow-up, the “metabolic/stroke” class was a significant predictor of lower levels of verbal fluency while the two multimorbidity classes predicted poor quality of life, problems in independent living, higher risk of hospitalization and greater use of health services. Conclusions Common chronic conditions in older people cluster together in broad categories. These broad clusters are qualitatively distinct and are important predictors of several health and functioning outcomes. Future studies are needed to understand underlying mechanisms and common risk factors for patterns of multimorbidity and to propose more effective treatments.http://link.springer.com/article/10.1186/s12877-017-0586-1ClustersMultimorbidityFollow-upOlder adultsCognitionQuality of life |
| spellingShingle | Beatriz Olaya Maria Victoria Moneta Francisco Félix Caballero Stefanos Tyrovolas Ivet Bayes José Luis Ayuso-Mateos Josep Maria Haro Latent class analysis of multimorbidity patterns and associated outcomes in Spanish older adults: a prospective cohort study BMC Geriatrics Clusters Multimorbidity Follow-up Older adults Cognition Quality of life |
| title | Latent class analysis of multimorbidity patterns and associated outcomes in Spanish older adults: a prospective cohort study |
| title_full | Latent class analysis of multimorbidity patterns and associated outcomes in Spanish older adults: a prospective cohort study |
| title_fullStr | Latent class analysis of multimorbidity patterns and associated outcomes in Spanish older adults: a prospective cohort study |
| title_full_unstemmed | Latent class analysis of multimorbidity patterns and associated outcomes in Spanish older adults: a prospective cohort study |
| title_short | Latent class analysis of multimorbidity patterns and associated outcomes in Spanish older adults: a prospective cohort study |
| title_sort | latent class analysis of multimorbidity patterns and associated outcomes in spanish older adults a prospective cohort study |
| topic | Clusters Multimorbidity Follow-up Older adults Cognition Quality of life |
| url | http://link.springer.com/article/10.1186/s12877-017-0586-1 |
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