Membrane erythrocyte proteins changes under noncalculous cholecystitis and crohn’s disease
The aim of the investigation was to reveal the changes in erythrocytes’ proteins from human blood under gastroenterological pathologies, namely noncalculous cholecystitis and Crohn’s disease. The erythrocyte was used as a model system. The PAAG electrophoresis with SDSNa method was used. Erythrocyte...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Oles Honchar Dnipropetrovsk National University
2010-10-01
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| Series: | Vìsnik Dnìpropetrovsʹkogo Unìversitetu: Serìâ Bìologìâ, Ekologìâ |
| Online Access: | http://ecology.dp.ua/index.php/ECO/article/view/117 |
| _version_ | 1798044981863120896 |
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| author | M. V. Gorelaya T. I. Sergienko I. V. Klenina O. M. Stadnik N. I. Shtemenko |
| author_facet | M. V. Gorelaya T. I. Sergienko I. V. Klenina O. M. Stadnik N. I. Shtemenko |
| author_sort | M. V. Gorelaya |
| collection | DOAJ |
| description | The aim of the investigation was to reveal the changes in erythrocytes’ proteins from human blood under gastroenterological pathologies, namely noncalculous cholecystitis and Crohn’s disease. The erythrocyte was used as a model system. The PAAG electrophoresis with SDSNa method was used. Erythrocyte membrane proteins quantitative changes were observed in patient groups under liver and intestines diseases. High molecular weight proteins content (spectrines α and β) was reduced, but any changes were not registered under the Crohn’s disease. Low molecular weight proteins content (anion-transporting protein and protein band 4.5) increased considerably as compared with a control (healthy people group). The structure of erythrocytes’ membrane changed, that led to disturbance of function of cytoskeleton proteins. The research results give more wide explanations of the pathologies genesis. |
| first_indexed | 2024-04-11T23:14:19Z |
| format | Article |
| id | doaj.art-75b4427d49174a75ae15315b30fd6809 |
| institution | Directory Open Access Journal |
| issn | 2310-0842 2312-301X |
| language | English |
| last_indexed | 2024-04-11T23:14:19Z |
| publishDate | 2010-10-01 |
| publisher | Oles Honchar Dnipropetrovsk National University |
| record_format | Article |
| series | Vìsnik Dnìpropetrovsʹkogo Unìversitetu: Serìâ Bìologìâ, Ekologìâ |
| spelling | doaj.art-75b4427d49174a75ae15315b30fd68092022-12-22T03:57:42ZengOles Honchar Dnipropetrovsk National UniversityVìsnik Dnìpropetrovsʹkogo Unìversitetu: Serìâ Bìologìâ, Ekologìâ2310-08422312-301X2010-10-0118291310.15421/011019117Membrane erythrocyte proteins changes under noncalculous cholecystitis and crohn’s diseaseM. V. GorelayaT. I. SergienkoI. V. KleninaO. M. StadnikN. I. ShtemenkoThe aim of the investigation was to reveal the changes in erythrocytes’ proteins from human blood under gastroenterological pathologies, namely noncalculous cholecystitis and Crohn’s disease. The erythrocyte was used as a model system. The PAAG electrophoresis with SDSNa method was used. Erythrocyte membrane proteins quantitative changes were observed in patient groups under liver and intestines diseases. High molecular weight proteins content (spectrines α and β) was reduced, but any changes were not registered under the Crohn’s disease. Low molecular weight proteins content (anion-transporting protein and protein band 4.5) increased considerably as compared with a control (healthy people group). The structure of erythrocytes’ membrane changed, that led to disturbance of function of cytoskeleton proteins. The research results give more wide explanations of the pathologies genesis.http://ecology.dp.ua/index.php/ECO/article/view/117 |
| spellingShingle | M. V. Gorelaya T. I. Sergienko I. V. Klenina O. M. Stadnik N. I. Shtemenko Membrane erythrocyte proteins changes under noncalculous cholecystitis and crohn’s disease Vìsnik Dnìpropetrovsʹkogo Unìversitetu: Serìâ Bìologìâ, Ekologìâ |
| title | Membrane erythrocyte proteins changes under noncalculous cholecystitis and crohn’s disease |
| title_full | Membrane erythrocyte proteins changes under noncalculous cholecystitis and crohn’s disease |
| title_fullStr | Membrane erythrocyte proteins changes under noncalculous cholecystitis and crohn’s disease |
| title_full_unstemmed | Membrane erythrocyte proteins changes under noncalculous cholecystitis and crohn’s disease |
| title_short | Membrane erythrocyte proteins changes under noncalculous cholecystitis and crohn’s disease |
| title_sort | membrane erythrocyte proteins changes under noncalculous cholecystitis and crohn s disease |
| url | http://ecology.dp.ua/index.php/ECO/article/view/117 |
| work_keys_str_mv | AT mvgorelaya membraneerythrocyteproteinschangesundernoncalculouscholecystitisandcrohnsdisease AT tisergienko membraneerythrocyteproteinschangesundernoncalculouscholecystitisandcrohnsdisease AT ivklenina membraneerythrocyteproteinschangesundernoncalculouscholecystitisandcrohnsdisease AT omstadnik membraneerythrocyteproteinschangesundernoncalculouscholecystitisandcrohnsdisease AT nishtemenko membraneerythrocyteproteinschangesundernoncalculouscholecystitisandcrohnsdisease |