Safety and efficacy of microorganism DSM 11798 as a technological additive for all avian species
Abstract Biomin® BBSH 797 is the trade name for a feed additive containing viable cells of an unnamed bacterium (DSM 11798). The EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) produced an opinion on the safety and efficacy of this additive when used with pigs conclud...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | EFSA Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.2903/j.efsa.2017.4676 |
| _version_ | 1818717903016427520 |
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| author | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Guido Rychen Gabriele Aquilina Giovanna Azimonti Vasileios Bampidis Maria deLourdes Bastos Georges Bories Andrew Chesson Pier Sandro Cocconcelli Gerhard Flachowsky Jürgen Gropp Boris Kolar Maryline Kouba Marta López‐Alonso Alberto Mantovani Baltasar Mayo Fernando Ramos Maria Saarela Roberto Edoardo Villa Robert John Wallace Pieter Wester Giovanna Martelli Derek Renshaw Secundino López Puente |
| author_facet | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Guido Rychen Gabriele Aquilina Giovanna Azimonti Vasileios Bampidis Maria deLourdes Bastos Georges Bories Andrew Chesson Pier Sandro Cocconcelli Gerhard Flachowsky Jürgen Gropp Boris Kolar Maryline Kouba Marta López‐Alonso Alberto Mantovani Baltasar Mayo Fernando Ramos Maria Saarela Roberto Edoardo Villa Robert John Wallace Pieter Wester Giovanna Martelli Derek Renshaw Secundino López Puente |
| author_sort | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) |
| collection | DOAJ |
| description | Abstract Biomin® BBSH 797 is the trade name for a feed additive containing viable cells of an unnamed bacterium (DSM 11798). The EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) produced an opinion on the safety and efficacy of this additive when used with pigs concluding that the additive itself did not raise any safety concern. It was confirmed that the additive could reduce the trichothecene, deoxynivalenol (DON), producing the less toxic de‐epoxy metabolite. The applicant is now seeking authorisation for the use of the additive in feed for all avian species and, since the current authorisation only covers DON, the amending of this authorisation to include all trichothecene mycotoxins. Chickens and turkeys for fattening and laying hens showed no adverse effects when the additive was added to diets at 1000 times the recommended dose. Consequently, the additive is considered safe for these species/categories when used at the recommended dose of 1.7 × 108 colony‐forming units (CFU)/kg complete feed. This conclusion is extended to all avian species. The use of the additive in feed for all avian species is not expected to introduce concerns for consumers, users or the environment not previously considered. In vitro and in vivo studies showed that the inclusion of the additive at the recommended dose of 1.7 × 108 CFU/kg was effective in reducing contaminating DON in feed when given to avian species with a concomitant production of the less toxic de‐epoxy metabolite. The additive was shown to reduce the 12,13‐epoxide group of representative trichothecenes. It would be reasonable to assume a similar reaction with other mycotoxins of the same structural type independent of the animal species or category receiving contaminated feed. The additive is compatible with the coccidiostats monensin sodium, salinomycin sodium, narasin, narasin/nicarbazin, nicarbazin, robenidine hydrochloride and diclazuril. |
| first_indexed | 2024-12-17T19:42:32Z |
| format | Article |
| id | doaj.art-75b6c1d9b5494a7d87dad0b207d16004 |
| institution | Directory Open Access Journal |
| issn | 1831-4732 |
| language | English |
| last_indexed | 2024-12-17T19:42:32Z |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | EFSA Journal |
| spelling | doaj.art-75b6c1d9b5494a7d87dad0b207d160042022-12-21T21:34:57ZengWileyEFSA Journal1831-47322017-01-01151n/an/a10.2903/j.efsa.2017.4676Safety and efficacy of microorganism DSM 11798 as a technological additive for all avian speciesEFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Guido RychenGabriele AquilinaGiovanna AzimontiVasileios BampidisMaria deLourdes BastosGeorges BoriesAndrew ChessonPier Sandro CocconcelliGerhard FlachowskyJürgen GroppBoris KolarMaryline KoubaMarta López‐AlonsoAlberto MantovaniBaltasar MayoFernando RamosMaria SaarelaRoberto Edoardo VillaRobert John WallacePieter WesterGiovanna MartelliDerek RenshawSecundino López PuenteAbstract Biomin® BBSH 797 is the trade name for a feed additive containing viable cells of an unnamed bacterium (DSM 11798). The EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) produced an opinion on the safety and efficacy of this additive when used with pigs concluding that the additive itself did not raise any safety concern. It was confirmed that the additive could reduce the trichothecene, deoxynivalenol (DON), producing the less toxic de‐epoxy metabolite. The applicant is now seeking authorisation for the use of the additive in feed for all avian species and, since the current authorisation only covers DON, the amending of this authorisation to include all trichothecene mycotoxins. Chickens and turkeys for fattening and laying hens showed no adverse effects when the additive was added to diets at 1000 times the recommended dose. Consequently, the additive is considered safe for these species/categories when used at the recommended dose of 1.7 × 108 colony‐forming units (CFU)/kg complete feed. This conclusion is extended to all avian species. The use of the additive in feed for all avian species is not expected to introduce concerns for consumers, users or the environment not previously considered. In vitro and in vivo studies showed that the inclusion of the additive at the recommended dose of 1.7 × 108 CFU/kg was effective in reducing contaminating DON in feed when given to avian species with a concomitant production of the less toxic de‐epoxy metabolite. The additive was shown to reduce the 12,13‐epoxide group of representative trichothecenes. It would be reasonable to assume a similar reaction with other mycotoxins of the same structural type independent of the animal species or category receiving contaminated feed. The additive is compatible with the coccidiostats monensin sodium, salinomycin sodium, narasin, narasin/nicarbazin, nicarbazin, robenidine hydrochloride and diclazuril.https://doi.org/10.2903/j.efsa.2017.4676technologicalmycotoxin binderchickensturkeyshensminor avian species |
| spellingShingle | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Guido Rychen Gabriele Aquilina Giovanna Azimonti Vasileios Bampidis Maria deLourdes Bastos Georges Bories Andrew Chesson Pier Sandro Cocconcelli Gerhard Flachowsky Jürgen Gropp Boris Kolar Maryline Kouba Marta López‐Alonso Alberto Mantovani Baltasar Mayo Fernando Ramos Maria Saarela Roberto Edoardo Villa Robert John Wallace Pieter Wester Giovanna Martelli Derek Renshaw Secundino López Puente Safety and efficacy of microorganism DSM 11798 as a technological additive for all avian species EFSA Journal technological mycotoxin binder chickens turkeys hens minor avian species |
| title | Safety and efficacy of microorganism DSM 11798 as a technological additive for all avian species |
| title_full | Safety and efficacy of microorganism DSM 11798 as a technological additive for all avian species |
| title_fullStr | Safety and efficacy of microorganism DSM 11798 as a technological additive for all avian species |
| title_full_unstemmed | Safety and efficacy of microorganism DSM 11798 as a technological additive for all avian species |
| title_short | Safety and efficacy of microorganism DSM 11798 as a technological additive for all avian species |
| title_sort | safety and efficacy of microorganism dsm 11798 as a technological additive for all avian species |
| topic | technological mycotoxin binder chickens turkeys hens minor avian species |
| url | https://doi.org/10.2903/j.efsa.2017.4676 |
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