Protein Z G79A polymorphism in Turkish pediatriccerebral infarct patients
Objective: Protein Z (PZ) plays an enhancer role in coagulation as an anticoagulant. In this study G79A polymorphism was investigated in Turkish pediatric stroke patients. Material and Methods: Ninety-one pediatric stroke patients with cerebral ischemia and 70 control subjects were analyzed for PZ G...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2008-09-01
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| Series: | Turkish Journal of Hematology |
| Subjects: | |
| Online Access: | http://www.journalagent.com/z4/download_fulltext.asp?pdir=tjh&plng=eng&un=TJH-32032 |
| _version_ | 1797912648518467584 |
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| author | Yonca Egin Gulhis Deda Nejat Akar Serap Teber Aysenur Ozturk |
| author_facet | Yonca Egin Gulhis Deda Nejat Akar Serap Teber Aysenur Ozturk |
| author_sort | Yonca Egin |
| collection | DOAJ |
| description | Objective: Protein Z (PZ) plays an enhancer role in coagulation as an anticoagulant. In this study G79A polymorphism was investigated in Turkish pediatric stroke patients. Material and Methods: Ninety-one pediatric stroke patients with cerebral ischemia and 70 control subjects were analyzed for PZ G79A and also factor V Leiden (FVL) and prothrombin (PT) mutations. Results: PZ 79 ‘A’ allele in homozygous state was found in five patients (5.5%), while it was found in only one control subject (1.4%), and it appeared to be a risk factor for pediatric ischemia [OR=3.94 (0.44-35.1)]. When patients and controls who had FVL and PT carriers were excluded, AA genotype carried a risk [OR=3.88 (0.41-36.5)]. In addition, plasma PZ levels were measured in 21 stroke patients and 52 controls. Plasma PZ levels were not different between stroke patients (501,0 ngml-1 ± 158,3 ngml-1) and controls (447,3 ngml-1 ± 166,0 ngml-1). However, the plasma levels of PZ were decreased in patients with AA genotype. This is the first study in which G79A polymorphism was investigated in Turkish pediatric stroke patientsConclusion: Our data showed that carrying 79 AA genotype could be a genetic risk factor for cerebral infarct in pediatric patients. |
| first_indexed | 2024-04-10T11:59:03Z |
| format | Article |
| id | doaj.art-75ba2e6a8a65499d81910505597a9175 |
| institution | Directory Open Access Journal |
| issn | 1300-7777 1308-5263 |
| language | English |
| last_indexed | 2024-04-10T11:59:03Z |
| publishDate | 2008-09-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Turkish Journal of Hematology |
| spelling | doaj.art-75ba2e6a8a65499d81910505597a91752023-02-15T16:16:40ZengGalenos Publishing HouseTurkish Journal of Hematology1300-77771308-52632008-09-012503133135Protein Z G79A polymorphism in Turkish pediatriccerebral infarct patientsYonca EginGulhis DedaNejat AkarSerap TeberAysenur OzturkObjective: Protein Z (PZ) plays an enhancer role in coagulation as an anticoagulant. In this study G79A polymorphism was investigated in Turkish pediatric stroke patients. Material and Methods: Ninety-one pediatric stroke patients with cerebral ischemia and 70 control subjects were analyzed for PZ G79A and also factor V Leiden (FVL) and prothrombin (PT) mutations. Results: PZ 79 ‘A’ allele in homozygous state was found in five patients (5.5%), while it was found in only one control subject (1.4%), and it appeared to be a risk factor for pediatric ischemia [OR=3.94 (0.44-35.1)]. When patients and controls who had FVL and PT carriers were excluded, AA genotype carried a risk [OR=3.88 (0.41-36.5)]. In addition, plasma PZ levels were measured in 21 stroke patients and 52 controls. Plasma PZ levels were not different between stroke patients (501,0 ngml-1 ± 158,3 ngml-1) and controls (447,3 ngml-1 ± 166,0 ngml-1). However, the plasma levels of PZ were decreased in patients with AA genotype. This is the first study in which G79A polymorphism was investigated in Turkish pediatric stroke patientsConclusion: Our data showed that carrying 79 AA genotype could be a genetic risk factor for cerebral infarct in pediatric patients.http://www.journalagent.com/z4/download_fulltext.asp?pdir=tjh&plng=eng&un=TJH-32032Protein ZPROZG79A polymorphismpediatric stroke. |
| spellingShingle | Yonca Egin Gulhis Deda Nejat Akar Serap Teber Aysenur Ozturk Protein Z G79A polymorphism in Turkish pediatriccerebral infarct patients Turkish Journal of Hematology Protein Z PROZ G79A polymorphism pediatric stroke. |
| title | Protein Z G79A polymorphism in Turkish pediatriccerebral infarct patients |
| title_full | Protein Z G79A polymorphism in Turkish pediatriccerebral infarct patients |
| title_fullStr | Protein Z G79A polymorphism in Turkish pediatriccerebral infarct patients |
| title_full_unstemmed | Protein Z G79A polymorphism in Turkish pediatriccerebral infarct patients |
| title_short | Protein Z G79A polymorphism in Turkish pediatriccerebral infarct patients |
| title_sort | protein z g79a polymorphism in turkish pediatriccerebral infarct patients |
| topic | Protein Z PROZ G79A polymorphism pediatric stroke. |
| url | http://www.journalagent.com/z4/download_fulltext.asp?pdir=tjh&plng=eng&un=TJH-32032 |
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