Effectiveness of Borage plus syrup on COVID-19 patients in intensive care units
IntroductionCOVID-19 (coronavirus disease-2019) still causes a high rate of death globally with no definite curative treatment described. The traditional plant Borage (Borago officinalis L.) is a good source of gamma-linolenic (GLA). We hypothesized that Borage plus syrup (BPS) would be beneficial i...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.975937/full |
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| author | Seyed MohammadReza Hashemian Esmaeil Mortaz Navid Shafigh Shadi Ziaie Hamidreza Jamaati Morteza Hasheminik Mehdi Jamalinik Raziyeh Erfani Batoul Khoundabi Neda K. Dezfuli Mohammad Varahram Shahrzad Ahmadi Mahdi Fahimi Ian M. Adcock Ian M. Adcock |
| author_facet | Seyed MohammadReza Hashemian Esmaeil Mortaz Navid Shafigh Shadi Ziaie Hamidreza Jamaati Morteza Hasheminik Mehdi Jamalinik Raziyeh Erfani Batoul Khoundabi Neda K. Dezfuli Mohammad Varahram Shahrzad Ahmadi Mahdi Fahimi Ian M. Adcock Ian M. Adcock |
| author_sort | Seyed MohammadReza Hashemian |
| collection | DOAJ |
| description | IntroductionCOVID-19 (coronavirus disease-2019) still causes a high rate of death globally with no definite curative treatment described. The traditional plant Borage (Borago officinalis L.) is a good source of gamma-linolenic (GLA). We hypothesized that Borage plus syrup (BPS) would be beneficial in severe COVID-19 patients within an intensive care unit (ICU) setting.Materials and methodsA pilot single center, randomized trial with no placebo was undertaken. A total of 60 PCR-positive severe COVID-19 participants admitted to ICU from June 2020–December 2020 at Masih Daneshvari Hospital Tehran-Iran gave informed consent. The participants were randomly assigned to either Borage Plus Syrup (BPS, 5 ml for 5 days) (n = 30) or standard care (IFN-β and favipiravir) as a control group (n = 30). Pao2/Fio2, serum ferritin, CRP, bilirubin, IL-6, TNF-α, ALT, AST, PCT and serum IL-8 was measured upon admission and on release.ResultsAll the measured parameters decreased significantly with BPS treatment. In the control group, most parameters significantly improved apart from AST and PCT. In addition, the suppression of serum TNF levels in the BPS group was greater than that seen in the control group (P ≤ 0.05). Moreover, the length of ICU stay was significantly lower in the BPS group compared with the control group (P ≤ 0.05).ConclusionOur study shows that addition of BPS to the standard treatment regime of COVID-19 patients in ICU improved outcomes and reduced the length of ICU treatment. Natural products could be considered as new approaches for reducting the harmful consequences of COVID-19. |
| first_indexed | 2024-04-11T06:47:06Z |
| format | Article |
| id | doaj.art-75bb26c7e0ee40efb53f1be2dfdd6754 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-11T06:47:06Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-75bb26c7e0ee40efb53f1be2dfdd67542022-12-22T04:39:20ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-11-01910.3389/fnut.2022.975937975937Effectiveness of Borage plus syrup on COVID-19 patients in intensive care unitsSeyed MohammadReza Hashemian0Esmaeil Mortaz1Navid Shafigh2Shadi Ziaie3Hamidreza Jamaati4Morteza Hasheminik5Mehdi Jamalinik6Raziyeh Erfani7Batoul Khoundabi8Neda K. Dezfuli9Mohammad Varahram10Shahrzad Ahmadi11Mahdi Fahimi12Ian M. Adcock13Ian M. Adcock14Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranChronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Anesthesiology and Critical Care Medicine, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, IranChronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Nursing, Sabzevar Branch, Islamic Azad University, Sabzevar, IranDepartment of Nursing, Tabas Branch, Islamic Azad University, Tabas, IranDepartment of Anesthesiology and Critical Care Medicine, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranResearch Center for Health Management in Mass Gathering, Red Crescent Society of the Islamic Republic of Iran, Tehran, IranCenter for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD, United StatesMycobacteriology Research Center (MRC), NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, IranChronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Naturopathic Medicine, Tehran, IranDepartment of Naturopathic Medicine, Tehran, Iran0Priority Research Centre for Asthma and Respiratory Disease, Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW, AustraliaIntroductionCOVID-19 (coronavirus disease-2019) still causes a high rate of death globally with no definite curative treatment described. The traditional plant Borage (Borago officinalis L.) is a good source of gamma-linolenic (GLA). We hypothesized that Borage plus syrup (BPS) would be beneficial in severe COVID-19 patients within an intensive care unit (ICU) setting.Materials and methodsA pilot single center, randomized trial with no placebo was undertaken. A total of 60 PCR-positive severe COVID-19 participants admitted to ICU from June 2020–December 2020 at Masih Daneshvari Hospital Tehran-Iran gave informed consent. The participants were randomly assigned to either Borage Plus Syrup (BPS, 5 ml for 5 days) (n = 30) or standard care (IFN-β and favipiravir) as a control group (n = 30). Pao2/Fio2, serum ferritin, CRP, bilirubin, IL-6, TNF-α, ALT, AST, PCT and serum IL-8 was measured upon admission and on release.ResultsAll the measured parameters decreased significantly with BPS treatment. In the control group, most parameters significantly improved apart from AST and PCT. In addition, the suppression of serum TNF levels in the BPS group was greater than that seen in the control group (P ≤ 0.05). Moreover, the length of ICU stay was significantly lower in the BPS group compared with the control group (P ≤ 0.05).ConclusionOur study shows that addition of BPS to the standard treatment regime of COVID-19 patients in ICU improved outcomes and reduced the length of ICU treatment. Natural products could be considered as new approaches for reducting the harmful consequences of COVID-19.https://www.frontiersin.org/articles/10.3389/fnut.2022.975937/fullARDSCOVID-19Boragecytokine stormCRPTNF-α |
| spellingShingle | Seyed MohammadReza Hashemian Esmaeil Mortaz Navid Shafigh Shadi Ziaie Hamidreza Jamaati Morteza Hasheminik Mehdi Jamalinik Raziyeh Erfani Batoul Khoundabi Neda K. Dezfuli Mohammad Varahram Shahrzad Ahmadi Mahdi Fahimi Ian M. Adcock Ian M. Adcock Effectiveness of Borage plus syrup on COVID-19 patients in intensive care units Frontiers in Nutrition ARDS COVID-19 Borage cytokine storm CRP TNF-α |
| title | Effectiveness of Borage plus syrup on COVID-19 patients in intensive care units |
| title_full | Effectiveness of Borage plus syrup on COVID-19 patients in intensive care units |
| title_fullStr | Effectiveness of Borage plus syrup on COVID-19 patients in intensive care units |
| title_full_unstemmed | Effectiveness of Borage plus syrup on COVID-19 patients in intensive care units |
| title_short | Effectiveness of Borage plus syrup on COVID-19 patients in intensive care units |
| title_sort | effectiveness of borage plus syrup on covid 19 patients in intensive care units |
| topic | ARDS COVID-19 Borage cytokine storm CRP TNF-α |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.975937/full |
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