Silk Fibroin Nanoparticle Functionalization with Arg-Gly-Asp Cyclopentapeptide Promotes Active Targeting for Tumor Site-Specific Delivery

Silk Fibroin Nanoparticle Functionalization with Arg-Gly-Asp Cyclopentapeptide Promotes Active Targeting for Tumor Site-Specific Delivery

Arg-Gly-Asp (RGD)-based cyclopentapeptides (cRGDs) have a high affinity towards integrin αvβ3 and αvβ5, which are overexpressed by many tumor cells. Here, curcumin-loaded silk fibroin nanoparticles (SFNs) have been functionalized on the surface with cRGD to provide active targeting towards tumor cel...

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Bibliographic Details
Main Authors: Elia Bari, Massimo Serra, Mayra Paolillo, Eric Bernardi, Sara Tengattini, Filippo Piccinini, Cristina Lanni, Marzio Sorlini, Giovanni Bisbano, Enrica Calleri, Maria Luisa Torre, Sara Perteghella
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cancers
Subjects:
silk fibroin nanoparticles
RGD
curcumin
anticancer
active targeting
Online Access:https://www.mdpi.com/2072-6694/13/5/1185

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