Cell Death Triggered by the Autophagy Inhibitory Drug 3-Methyladenine in Growing Conditions Proceeds With DNA Damage

Cell Death Triggered by the Autophagy Inhibitory Drug 3-Methyladenine in Growing Conditions Proceeds With DNA Damage

Macroautophagy (hereafter autophagy) is a multistep intracellular catabolic process with pleiotropic implications in cell fate. Attending to its activation, autophagy can be classified into inducible or constitutive. Constitutive, or basal autophagy, unfolds under nutrient-replete conditions to main...

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Bibliographic Details
Main Authors: Javier Chicote, Víctor J. Yuste, Jacint Boix, Judit Ribas
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Pharmacology
Subjects:
3-methyladenine
autophagy inhibitor
basal autophagy
Ɣ-H2A.X
apoptosis
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.580343/full

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