Ribosomal Hibernation-Associated Factors in <i>Escherichia coli</i>
Bacteria convert active 70S ribosomes to inactive 100S ribosomes to survive under various stress conditions. This state, in which the ribosome loses its translational activity, is known as ribosomal hibernation. In gammaproteobacteria such as <i>Escherichia coli</i>, ribosome modulation...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-12-01
|
| Series: | Microorganisms |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2607/10/1/33 |
| _version_ | 1827664053370093568 |
|---|---|
| author | Yasushi Maki Hideji Yoshida |
| author_facet | Yasushi Maki Hideji Yoshida |
| author_sort | Yasushi Maki |
| collection | DOAJ |
| description | Bacteria convert active 70S ribosomes to inactive 100S ribosomes to survive under various stress conditions. This state, in which the ribosome loses its translational activity, is known as ribosomal hibernation. In gammaproteobacteria such as <i>Escherichia coli</i>, ribosome modulation factor and hibernation-promoting factor are involved in forming 100S ribosomes. The expression of ribosome modulation factor is regulated by (p)ppGpp (which is induced by amino acid starvation), cAMP-CRP (which is stimulated by reduced metabolic energy), and transcription factors involved in biofilm formation. This indicates that the formation of 100S ribosomes is an important strategy for bacterial survival under various stress conditions. In recent years, the structures of 100S ribosomes from various bacteria have been reported, enhancing our understanding of the 100S ribosome. Here, we present previous findings on the 100S ribosome and related proteins and describe the stress-response pathways involved in ribosomal hibernation. |
| first_indexed | 2024-03-10T00:53:52Z |
| format | Article |
| id | doaj.art-75bbbc777c3e494b9ac3a7a07d6a4b46 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T00:53:52Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-75bbbc777c3e494b9ac3a7a07d6a4b462023-11-23T14:46:13ZengMDPI AGMicroorganisms2076-26072021-12-011013310.3390/microorganisms10010033Ribosomal Hibernation-Associated Factors in <i>Escherichia coli</i>Yasushi Maki0Hideji Yoshida1Department of Physics, Osaka Medical and Pharmaceutical University, Takatsuki 569-8686, JapanDepartment of Physics, Osaka Medical and Pharmaceutical University, Takatsuki 569-8686, JapanBacteria convert active 70S ribosomes to inactive 100S ribosomes to survive under various stress conditions. This state, in which the ribosome loses its translational activity, is known as ribosomal hibernation. In gammaproteobacteria such as <i>Escherichia coli</i>, ribosome modulation factor and hibernation-promoting factor are involved in forming 100S ribosomes. The expression of ribosome modulation factor is regulated by (p)ppGpp (which is induced by amino acid starvation), cAMP-CRP (which is stimulated by reduced metabolic energy), and transcription factors involved in biofilm formation. This indicates that the formation of 100S ribosomes is an important strategy for bacterial survival under various stress conditions. In recent years, the structures of 100S ribosomes from various bacteria have been reported, enhancing our understanding of the 100S ribosome. Here, we present previous findings on the 100S ribosome and related proteins and describe the stress-response pathways involved in ribosomal hibernation.https://www.mdpi.com/2076-2607/10/1/33100S ribosomeribosome modulation factorhibernation-promoting factorribosomal hibernationstress response |
| spellingShingle | Yasushi Maki Hideji Yoshida Ribosomal Hibernation-Associated Factors in <i>Escherichia coli</i> Microorganisms 100S ribosome ribosome modulation factor hibernation-promoting factor ribosomal hibernation stress response |
| title | Ribosomal Hibernation-Associated Factors in <i>Escherichia coli</i> |
| title_full | Ribosomal Hibernation-Associated Factors in <i>Escherichia coli</i> |
| title_fullStr | Ribosomal Hibernation-Associated Factors in <i>Escherichia coli</i> |
| title_full_unstemmed | Ribosomal Hibernation-Associated Factors in <i>Escherichia coli</i> |
| title_short | Ribosomal Hibernation-Associated Factors in <i>Escherichia coli</i> |
| title_sort | ribosomal hibernation associated factors in i escherichia coli i |
| topic | 100S ribosome ribosome modulation factor hibernation-promoting factor ribosomal hibernation stress response |
| url | https://www.mdpi.com/2076-2607/10/1/33 |
| work_keys_str_mv | AT yasushimaki ribosomalhibernationassociatedfactorsiniescherichiacolii AT hidejiyoshida ribosomalhibernationassociatedfactorsiniescherichiacolii |