Integrative analysis of mutated genes and mutational processes reveals novel mutational biomarkers in colorectal cancer

Integrative analysis of mutated genes and mutational processes reveals novel mutational biomarkers in colorectal cancer

Abstract Background Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. Recent studies have observed causative mutations in susceptible genes related to colorectal cancer in 10 to 15% of the patients. This highlights the importance of identifying mutations for ea...

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Bibliographic Details
Main Authors: Hamed Dashti, Iman Dehzangi, Masroor Bayati, James Breen, Amin Beheshti, Nigel Lovell, Hamid R. Rabiee, Hamid Alinejad-Rokny
Format: Article
Language:English
Published: BMC 2022-04-01
Series:BMC Bioinformatics
Subjects:
Colorectal cancer
Cancer subtype identification
Somatic point mutations
Motif analysis
Gene prioritization
Therapeutic targets
Online Access:https://doi.org/10.1186/s12859-022-04652-8

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