Frailty and muscle weakness in elderly patients with asthma and their association with cumulative lifetime oral corticosteroid exposure
Background: Frailty is a geriatric syndrome of age-related physiological decline, which is associated with higher mortality and decreased healthy life expectancy, and muscle weakness is one of the presentations of frailty. We investigated an association between lifetime oral corticosteroid (OCS) exp...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | Allergology International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1323893022001228 |
| _version_ | 1797854536977612800 |
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| author | Kai Ryu Yuma Fukutomi Eiji Nakatani Maki Iwata Kisako Nagayama Koichi Yano Yuto Nakamura Yuto Hamada Kentaro Watai Yosuke Kamide Kiyoshi Sekiya Jun Araya Kazuyoshi Kuwano Masami Taniguchi |
| author_facet | Kai Ryu Yuma Fukutomi Eiji Nakatani Maki Iwata Kisako Nagayama Koichi Yano Yuto Nakamura Yuto Hamada Kentaro Watai Yosuke Kamide Kiyoshi Sekiya Jun Araya Kazuyoshi Kuwano Masami Taniguchi |
| author_sort | Kai Ryu |
| collection | DOAJ |
| description | Background: Frailty is a geriatric syndrome of age-related physiological decline, which is associated with higher mortality and decreased healthy life expectancy, and muscle weakness is one of the presentations of frailty. We investigated an association between lifetime oral corticosteroid (OCS) exposure with frailty and muscle weakness among elderly patients with asthma. Methods: We studied 203 consecutive elderly outpatients with asthma aged ≥60 years old. They were classified into three groups according to their cumulative lifetime OCS dose (lifetime non-users, lower-dose users, and higher-dose users), which was retrospectively estimated from the response to a structured questionnaire. The prevalence of frailty determined by the Kihon Checklist was compared between the three groups. Hand-grip strength, and lean mass index were also measured as markers of muscle strength. Results: Thirty-seven percent of the patients studied were considered frail. Higher cumulative lifetime OCS exposure was associated with a significantly higher prevalence of frailty (33% in lifetime non-users, 59% in lower-dose users, and 68% in higher-dose users; P for trend <0.005). This was also associated with lower hand-grip strength in both sexes (P for trend; 0.012 in men, and 0.020 in women), and lower lean mass index in men (P for trend 0.002). However, current doses of OCS were not significantly associated with these outcomes. Conclusions: Cumulative lifetime OCS exposure was associated with a higher prevalence of frailty and muscle weakness. These findings emphasize the importance of minimizing lifetime OCS exposure for the prolongation of healthy life expectancy in patients with asthma. |
| first_indexed | 2024-04-09T20:08:45Z |
| format | Article |
| id | doaj.art-75bda25633994eca9db34c82aad4d312 |
| institution | Directory Open Access Journal |
| issn | 1323-8930 |
| language | English |
| last_indexed | 2024-04-09T20:08:45Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Allergology International |
| spelling | doaj.art-75bda25633994eca9db34c82aad4d3122023-04-01T08:45:54ZengElsevierAllergology International1323-89302023-04-01722252261Frailty and muscle weakness in elderly patients with asthma and their association with cumulative lifetime oral corticosteroid exposureKai Ryu0Yuma Fukutomi1Eiji Nakatani2Maki Iwata3Kisako Nagayama4Koichi Yano5Yuto Nakamura6Yuto Hamada7Kentaro Watai8Yosuke Kamide9Kiyoshi Sekiya10Jun Araya11Kazuyoshi Kuwano12Masami Taniguchi13Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Kanagawa, Japan; Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, JapanClinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Kanagawa, Japan; Corresponding author. Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, 18-1 Sakuradai, Minami-ku, Sagamihara, Kanagawa 252-0392, Japan.Graduate School of Public Health, Shizuoka Graduate University of Public Health, Shizuoka, JapanClinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Kanagawa, JapanClinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Kanagawa, JapanClinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Kanagawa, JapanClinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Kanagawa, JapanClinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Kanagawa, JapanClinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Kanagawa, Japan; Center for Immunology and Allergology, Shonan Kamakura General Hospital, Kanagawa, JapanClinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Kanagawa, JapanClinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Kanagawa, JapanDivision of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, JapanDivision of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, JapanClinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Kanagawa, Japan; Center for Immunology and Allergology, Shonan Kamakura General Hospital, Kanagawa, Japan; Corresponding author. Center for Immunology and Allergology, Shonan Kamakura General Hospital, 1370-1 Okamoto, Kamakura, Kanagawa 252-0392 Japan.Background: Frailty is a geriatric syndrome of age-related physiological decline, which is associated with higher mortality and decreased healthy life expectancy, and muscle weakness is one of the presentations of frailty. We investigated an association between lifetime oral corticosteroid (OCS) exposure with frailty and muscle weakness among elderly patients with asthma. Methods: We studied 203 consecutive elderly outpatients with asthma aged ≥60 years old. They were classified into three groups according to their cumulative lifetime OCS dose (lifetime non-users, lower-dose users, and higher-dose users), which was retrospectively estimated from the response to a structured questionnaire. The prevalence of frailty determined by the Kihon Checklist was compared between the three groups. Hand-grip strength, and lean mass index were also measured as markers of muscle strength. Results: Thirty-seven percent of the patients studied were considered frail. Higher cumulative lifetime OCS exposure was associated with a significantly higher prevalence of frailty (33% in lifetime non-users, 59% in lower-dose users, and 68% in higher-dose users; P for trend <0.005). This was also associated with lower hand-grip strength in both sexes (P for trend; 0.012 in men, and 0.020 in women), and lower lean mass index in men (P for trend 0.002). However, current doses of OCS were not significantly associated with these outcomes. Conclusions: Cumulative lifetime OCS exposure was associated with a higher prevalence of frailty and muscle weakness. These findings emphasize the importance of minimizing lifetime OCS exposure for the prolongation of healthy life expectancy in patients with asthma.http://www.sciencedirect.com/science/article/pii/S1323893022001228AsthmaElderlyFrailtyHealthy life expectancyOral corticosteroids |
| spellingShingle | Kai Ryu Yuma Fukutomi Eiji Nakatani Maki Iwata Kisako Nagayama Koichi Yano Yuto Nakamura Yuto Hamada Kentaro Watai Yosuke Kamide Kiyoshi Sekiya Jun Araya Kazuyoshi Kuwano Masami Taniguchi Frailty and muscle weakness in elderly patients with asthma and their association with cumulative lifetime oral corticosteroid exposure Allergology International Asthma Elderly Frailty Healthy life expectancy Oral corticosteroids |
| title | Frailty and muscle weakness in elderly patients with asthma and their association with cumulative lifetime oral corticosteroid exposure |
| title_full | Frailty and muscle weakness in elderly patients with asthma and their association with cumulative lifetime oral corticosteroid exposure |
| title_fullStr | Frailty and muscle weakness in elderly patients with asthma and their association with cumulative lifetime oral corticosteroid exposure |
| title_full_unstemmed | Frailty and muscle weakness in elderly patients with asthma and their association with cumulative lifetime oral corticosteroid exposure |
| title_short | Frailty and muscle weakness in elderly patients with asthma and their association with cumulative lifetime oral corticosteroid exposure |
| title_sort | frailty and muscle weakness in elderly patients with asthma and their association with cumulative lifetime oral corticosteroid exposure |
| topic | Asthma Elderly Frailty Healthy life expectancy Oral corticosteroids |
| url | http://www.sciencedirect.com/science/article/pii/S1323893022001228 |
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