An Arrhythmic Mutation E7K Facilitates TRPM4 Channel Activation via Enhanced PIP<sub>2</sub> Interaction

An Arrhythmic Mutation E7K Facilitates TRPM4 Channel Activation via Enhanced PIP<sub>2</sub> Interaction

A Ca<sup>2+</sup>-activated monovalent cation-selective TRPM4 channel is abundantly expressed in the heart. Recently, a single gain-of-function mutation identified in the distal N-terminus of the human TRPM4 channel (Glu<sup>5</sup> to Lys<sup>5</sup>; E7K) was fo...

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Bibliographic Details
Main Authors:	Yaopeng Hu, Qin Li, Lin-Hai Kurahara, Narumi Shioi, Keizo Hiraishi, Takayuki Fujita, Xin Zhu, Ryuji Inoue
Format:	Article
Language:	English
Published:	MDPI AG 2021-04-01
Series:	Cells
Subjects:	arrhythmogenicity PIP<sub>2</sub> TRP channel
Online Access:	https://www.mdpi.com/2073-4409/10/5/983

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