Application of L-FDM Technology to the Printing of Tablets That Release Active Substances—Preliminary Research
The following work presents a method for obtaining PLA composites with activated carbon modified using the liquid for fused deposition modeling (L-FDM) method in which two different compounds, i.e., rhodamine and antipyrine, are introduced. Tablets saturated with substances were obtained. Microscopi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | C |
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| Online Access: | https://www.mdpi.com/2311-5629/10/1/23 |
| _version_ | 1797241664868188160 |
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| author | Ewa Gabriel Anna Olejnik Bogna Sztorch Miłosz Frydrych Olga Czerwińska Robert Pietrzak Robert E. Przekop |
| author_facet | Ewa Gabriel Anna Olejnik Bogna Sztorch Miłosz Frydrych Olga Czerwińska Robert Pietrzak Robert E. Przekop |
| author_sort | Ewa Gabriel |
| collection | DOAJ |
| description | The following work presents a method for obtaining PLA composites with activated carbon modified using the liquid for fused deposition modeling (L-FDM) method in which two different compounds, i.e., rhodamine and antipyrine, are introduced. Tablets saturated with substances were obtained. Microscopic tests were carried out, and these confirmed the presence of substances that had been introduced into the polymer structure. UV-Vis spectra and observation of the active substance release process confirmed the relationship between the printing speed and the amounts of the compounds liberated from the tablets. Additionally, the contact angle of the PLA with activated carbon composites was characterized. The hydrophilic nature of the obtained composites favors an increase in the amounts of compounds released during the release process, which is a desirable effect. The surfaces and pores of the obtained materials were also analyzed. The incorporation of activated carbon into PLA results in a significant increase in its surface area. Investigations indicate that a novel approach for introducing chemicals into polymer matrices through the L-FDM method holds promise for the prospective fabrication of tablets capable of a controlled and customized release of substances tailored to individual requirements. |
| first_indexed | 2024-04-24T18:26:56Z |
| format | Article |
| id | doaj.art-75c0baaf123a4fc580beb29caf2691ec |
| institution | Directory Open Access Journal |
| issn | 2311-5629 |
| language | English |
| last_indexed | 2024-04-24T18:26:56Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | C |
| spelling | doaj.art-75c0baaf123a4fc580beb29caf2691ec2024-03-27T13:30:16ZengMDPI AGC2311-56292024-03-011012310.3390/c10010023Application of L-FDM Technology to the Printing of Tablets That Release Active Substances—Preliminary ResearchEwa Gabriel0Anna Olejnik1Bogna Sztorch2Miłosz Frydrych3Olga Czerwińska4Robert Pietrzak5Robert E. Przekop6Faculty of Chemistry, Adam Mickiewicz University in Poznan, 8 Uniwersytetu Poznanskiego, 61-614 Poznan, PolandFaculty of Chemistry, Adam Mickiewicz University in Poznan, 8 Uniwersytetu Poznanskiego, 61-614 Poznan, PolandCentre for Advanced Technologies, Adam Mickiewicz University in Poznan, 10 Uniwersytetu Poznanskiego, 61-614 Poznan, PolandCentre for Advanced Technologies, Adam Mickiewicz University in Poznan, 10 Uniwersytetu Poznanskiego, 61-614 Poznan, PolandSygnis S.A., Al. Grunwaldzka 472, 80-309 Gdansk, PolandFaculty of Chemistry, Adam Mickiewicz University in Poznan, 8 Uniwersytetu Poznanskiego, 61-614 Poznan, PolandCentre for Advanced Technologies, Adam Mickiewicz University in Poznan, 10 Uniwersytetu Poznanskiego, 61-614 Poznan, PolandThe following work presents a method for obtaining PLA composites with activated carbon modified using the liquid for fused deposition modeling (L-FDM) method in which two different compounds, i.e., rhodamine and antipyrine, are introduced. Tablets saturated with substances were obtained. Microscopic tests were carried out, and these confirmed the presence of substances that had been introduced into the polymer structure. UV-Vis spectra and observation of the active substance release process confirmed the relationship between the printing speed and the amounts of the compounds liberated from the tablets. Additionally, the contact angle of the PLA with activated carbon composites was characterized. The hydrophilic nature of the obtained composites favors an increase in the amounts of compounds released during the release process, which is a desirable effect. The surfaces and pores of the obtained materials were also analyzed. The incorporation of activated carbon into PLA results in a significant increase in its surface area. Investigations indicate that a novel approach for introducing chemicals into polymer matrices through the L-FDM method holds promise for the prospective fabrication of tablets capable of a controlled and customized release of substances tailored to individual requirements.https://www.mdpi.com/2311-5629/10/1/23L-FDMliquid for fused deposition modelingprinted medicinescarbon composites |
| spellingShingle | Ewa Gabriel Anna Olejnik Bogna Sztorch Miłosz Frydrych Olga Czerwińska Robert Pietrzak Robert E. Przekop Application of L-FDM Technology to the Printing of Tablets That Release Active Substances—Preliminary Research C L-FDM liquid for fused deposition modeling printed medicines carbon composites |
| title | Application of L-FDM Technology to the Printing of Tablets That Release Active Substances—Preliminary Research |
| title_full | Application of L-FDM Technology to the Printing of Tablets That Release Active Substances—Preliminary Research |
| title_fullStr | Application of L-FDM Technology to the Printing of Tablets That Release Active Substances—Preliminary Research |
| title_full_unstemmed | Application of L-FDM Technology to the Printing of Tablets That Release Active Substances—Preliminary Research |
| title_short | Application of L-FDM Technology to the Printing of Tablets That Release Active Substances—Preliminary Research |
| title_sort | application of l fdm technology to the printing of tablets that release active substances preliminary research |
| topic | L-FDM liquid for fused deposition modeling printed medicines carbon composites |
| url | https://www.mdpi.com/2311-5629/10/1/23 |
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