Sex differences in the characteristics and survival of patients with non‐small‐cell lung cancer: A retrospective analytical study based on real‐world clinical data of the Korean population
Abstract Purpose This study aimed to investigate the differences in characteristics, clinical stages, treatment modalities, and survival outcomes in patients with non‐small‐cell lung cancer (NSCLC) based on sex differences using Korean nationwide registry data. Methods We analyzed the data of 8650 p...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-09-01
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| Series: | Thoracic Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/1759-7714.14594 |
| _version_ | 1797995302651691008 |
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| author | Da Som Jeon Jin Woo Kim Seul Gi Kim Hyeong Ryul Kim Si Yeol Song Jae Cheol Lee Wonjun Ji Chang‐Min Choi Ho Cheol Kim Korean Association for Lung Cancer, South Korea Central Cancer Registry |
| author_facet | Da Som Jeon Jin Woo Kim Seul Gi Kim Hyeong Ryul Kim Si Yeol Song Jae Cheol Lee Wonjun Ji Chang‐Min Choi Ho Cheol Kim Korean Association for Lung Cancer, South Korea Central Cancer Registry |
| author_sort | Da Som Jeon |
| collection | DOAJ |
| description | Abstract Purpose This study aimed to investigate the differences in characteristics, clinical stages, treatment modalities, and survival outcomes in patients with non‐small‐cell lung cancer (NSCLC) based on sex differences using Korean nationwide registry data. Methods We analyzed the data of 8650 patients diagnosed with NSCLC between 2014 and 2017, obtained from the Korean Association for Lung Cancer Registry (KALC‐R). The Cox proportional hazard model was used to define the differences in survival based on sex. Propensity score matching was used to adjust for differences between men and women. Results Of a total of 10 943 patients, 8650 (79.1%) were diagnosed with NSCLC, of whom 68.7% were men and 31.3% were women. For NSCLC, the median age was higher (69.0 vs. 67.0, p < 0.001) and the proportion of ever‐smokers (84.5% vs. 10.8%, p < 0.001) was higher in men. Adenocarcinoma (55.5% vs. 90.4%, p < 0.001) and stage I NSCLC (26.3% vs. 41.3%, p < 0.001) were more common in women. Survival was significantly lower in men with NSCLC (hazard ratio [HR] 1.493 [95% confidence interval, CI 1.238–1.800], p < 0.001) even after adjusting for meaningful clinical variables, and in the matched cohort (HR 1.339 [1.075–1.667], p = 0.009). Similarly, survival was significantly lower in men with stage IV adenocarcinoma after adjusting for other clinical variables (HR 1.493 [1.238–1.800], p < 0.001) and in the matched cohort (HR 1.339 [1.075–1.667]; p = 0.009). Conclusions Male patients with NSCLC had poorer prognosis, not only after variable adjustments for prognostic factors, but also in the matched cohort. |
| first_indexed | 2024-04-11T09:59:35Z |
| format | Article |
| id | doaj.art-75c190ca8a7049dabaa3780fac9ff56c |
| institution | Directory Open Access Journal |
| issn | 1759-7706 1759-7714 |
| language | English |
| last_indexed | 2024-04-11T09:59:35Z |
| publishDate | 2022-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj.art-75c190ca8a7049dabaa3780fac9ff56c2022-12-22T04:30:27ZengWileyThoracic Cancer1759-77061759-77142022-09-0113182584259110.1111/1759-7714.14594Sex differences in the characteristics and survival of patients with non‐small‐cell lung cancer: A retrospective analytical study based on real‐world clinical data of the Korean populationDa Som Jeon0Jin Woo Kim1Seul Gi Kim2Hyeong Ryul Kim3Si Yeol Song4Jae Cheol Lee5Wonjun Ji6Chang‐Min Choi7Ho Cheol Kim8Korean Association for Lung Cancer, South Korea Central Cancer RegistryDepartment of Pulmonary and Critical Care Medicine, Asan Medical Center University of Ulsan College of Medicine Seoul South KoreaRespiratory and Pulmonary Disease Laboratory, Biomedical Research Center Asan Medical Center Seoul South KoreaDepartment of Pulmonary and Critical Care Medicine, Asan Medical Center University of Ulsan College of Medicine Seoul South KoreaDepartment of Thoracic and Cardiovascular Surgery, Asan Medical Center University of Ulsan College of Medicine Seoul South KoreaDepartment of Radiation Oncology, Asan Medical Center University of Ulsan College of Medicine Seoul South KoreaDepartment of Oncology, Asan Medical Center University of Ulsan College of Medicine Seoul South KoreaDepartment of Pulmonary and Critical Care Medicine, Asan Medical Center University of Ulsan College of Medicine Seoul South KoreaDepartment of Pulmonary and Critical Care Medicine, Asan Medical Center University of Ulsan College of Medicine Seoul South KoreaDepartment of Pulmonary and Critical Care Medicine, Asan Medical Center University of Ulsan College of Medicine Seoul South KoreaAbstract Purpose This study aimed to investigate the differences in characteristics, clinical stages, treatment modalities, and survival outcomes in patients with non‐small‐cell lung cancer (NSCLC) based on sex differences using Korean nationwide registry data. Methods We analyzed the data of 8650 patients diagnosed with NSCLC between 2014 and 2017, obtained from the Korean Association for Lung Cancer Registry (KALC‐R). The Cox proportional hazard model was used to define the differences in survival based on sex. Propensity score matching was used to adjust for differences between men and women. Results Of a total of 10 943 patients, 8650 (79.1%) were diagnosed with NSCLC, of whom 68.7% were men and 31.3% were women. For NSCLC, the median age was higher (69.0 vs. 67.0, p < 0.001) and the proportion of ever‐smokers (84.5% vs. 10.8%, p < 0.001) was higher in men. Adenocarcinoma (55.5% vs. 90.4%, p < 0.001) and stage I NSCLC (26.3% vs. 41.3%, p < 0.001) were more common in women. Survival was significantly lower in men with NSCLC (hazard ratio [HR] 1.493 [95% confidence interval, CI 1.238–1.800], p < 0.001) even after adjusting for meaningful clinical variables, and in the matched cohort (HR 1.339 [1.075–1.667], p = 0.009). Similarly, survival was significantly lower in men with stage IV adenocarcinoma after adjusting for other clinical variables (HR 1.493 [1.238–1.800], p < 0.001) and in the matched cohort (HR 1.339 [1.075–1.667]; p = 0.009). Conclusions Male patients with NSCLC had poorer prognosis, not only after variable adjustments for prognostic factors, but also in the matched cohort.https://doi.org/10.1111/1759-7714.14594epidemiologyKorealung cancersexsurvival |
| spellingShingle | Da Som Jeon Jin Woo Kim Seul Gi Kim Hyeong Ryul Kim Si Yeol Song Jae Cheol Lee Wonjun Ji Chang‐Min Choi Ho Cheol Kim Korean Association for Lung Cancer, South Korea Central Cancer Registry Sex differences in the characteristics and survival of patients with non‐small‐cell lung cancer: A retrospective analytical study based on real‐world clinical data of the Korean population Thoracic Cancer epidemiology Korea lung cancer sex survival |
| title | Sex differences in the characteristics and survival of patients with non‐small‐cell lung cancer: A retrospective analytical study based on real‐world clinical data of the Korean population |
| title_full | Sex differences in the characteristics and survival of patients with non‐small‐cell lung cancer: A retrospective analytical study based on real‐world clinical data of the Korean population |
| title_fullStr | Sex differences in the characteristics and survival of patients with non‐small‐cell lung cancer: A retrospective analytical study based on real‐world clinical data of the Korean population |
| title_full_unstemmed | Sex differences in the characteristics and survival of patients with non‐small‐cell lung cancer: A retrospective analytical study based on real‐world clinical data of the Korean population |
| title_short | Sex differences in the characteristics and survival of patients with non‐small‐cell lung cancer: A retrospective analytical study based on real‐world clinical data of the Korean population |
| title_sort | sex differences in the characteristics and survival of patients with non small cell lung cancer a retrospective analytical study based on real world clinical data of the korean population |
| topic | epidemiology Korea lung cancer sex survival |
| url | https://doi.org/10.1111/1759-7714.14594 |
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