Differentiated modulation of signaling molecules AMPK and SIRT1 in experimentally drug-induced hepatocyte injury

Differentiated modulation of signaling molecules AMPK and SIRT1 in experimentally drug-induced hepatocyte injury

Aim. Currently available medicines have little to offer in terms of supporting the regeneration of injured hepatic cells. Previous experimental studies have shown that resveratrol and metformin, less specific activators of AMP-activated protein kinase (AMPK) and sirtuin 1 (SIRT1), can effectively at...

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Bibliographic Details
Main Authors: Lea Njeka Wojnarova, Nikolina Kutinova Canova, Mahak Arora, Hassan Farghali
Format: Article
Language:English
Published: Palacký University Olomouc, Faculty of Medicine and Dentistry 2023-03-01
Series:Biomedical Papers
Subjects:
5-aminoimidazole-4-carboxamide ribonucleotide (aicar)
adenosine monophosphate protein kinase (ampk)
cay10591
enzyme activation
hepatocyte protection
sirtuin 1 (sirt1)
Online Access:https://biomed.papers.upol.cz/artkey/bio-202301-0008_differentiated-modulation-of-signaling-molecules-ampk-and-sirt1-in-experimentally-drug-induced-hepatocyte-injur.php

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