Generation of an enhancer-driven gene expression viral tool specific to dentate granule cell-types through direct hippocampal injection

Generation of an enhancer-driven gene expression viral tool specific to dentate granule cell-types through direct hippocampal injection

Accurate investigations of neural circuitry require specific genetic access to individual circuit elements, i.e., the myriad neuronal cell-types in the brain. However, native promoters cannot achieve this because while most genes are expressed in the brain, few are expressed in a single neuronal cel...

Full description

Bibliographic Details
Main Authors: Maria Letizia Potenza, Stefan Blankvoort, Miguel M. Carvalho, Joachim S. Grimstvedt, Valentina Di Maria, Kristian Moan, Rajeevkumar Raveendran Nair, Marcus S. Flatset, Qiangwei Zhang, Laurent F. Thomas, Francois P. Pauzin, Rodolfo Da Silva Mazzarini Baldinotti, Giulia Quattrocolo, Clive R. Bramham, Pål Sætrom, Menno P. Witter, Clifford G. Kentros
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Neuroscience
Subjects:
rAAVs
dentate gyrus
genetic tool
chromatin immunoprecipitation
stereotaxic injection
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2024.1274174/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2024.1274174/full

Similar Items