Maggot Extract Inhibits Cell Migration and Tumor Growth by Targeting HSP90AB1 in Ovarian Cancer

Maggot Extract Inhibits Cell Migration and Tumor Growth by Targeting HSP90AB1 in Ovarian Cancer

Ovarian cancer is one of the most lethal gynecological malignancies, because of metastatic dissemination with poor late clinical therapy. Maggots have been used in traditional Chinese medicine, where they are also known as ‘Wu Gu Chong’. Previous studies have indicated that maggot extract (ME) was b...

Full description

Bibliographic Details
Main Authors:	Daojuan Wang, Rong Wang, Mengru Cai, Yaling Zhang, Zhengquan Zhu, Yajing Weng, Lei Wang, Ying Huang, Ronghui Du, Xiaoke Wu, Gaojian Tao, Yong Wang
Format:	Article
Language:	English
Published:	MDPI AG 2022-10-01
Series:	Journal of Clinical Medicine
Subjects:	maggot extracts ovarian cancer cell proliferation cancer metastasis HSP90AB1
Online Access:	https://www.mdpi.com/2077-0383/11/21/6271

Similar Items

DSCC1 interacts with HSP90AB1 and promotes the progression of lung adenocarcinoma via regulating ER stress
by: Xu Lin, et al.
Published: (2023-09-01)

The Distinct Assignments for Hsp90α and Hsp90β: More Than Skin Deep
by: Cheng Chang, et al.
Published: (2023-01-01)

Analysis of the prognostic, diagnostic and immunological role of HSP90α in malignant tumors
by: Zhimin Yuan, et al.
Published: (2022-09-01)

Inhibition of Embryonic HSP 90 Function Promotes Variation of Cold Tolerance in Zebrafish
by: Bingshe Han, et al.
Published: (2020-12-01)

Aberrant HSP90 Expression in Lymphocytes and HSP90 Response to Anti-PD-1 Therapy in Lymphoma Patients
by: Zarema Albakova, et al.
Published: (2022-04-01)

PADI3 plays an antitumor role via the Hsp90/CKS1 pathway in colon cancer
by: Zhengbin Chai, et al.
Published: (2019-11-01)

Targeting HSP90 in ovarian cancers with multiple receptor tyrosine kinase coactivation
by: Zhou Haimeng, et al.
Published: (2011-09-01)

BJ-B11, an Hsp90 Inhibitor, Constrains the Proliferation and Invasion of Breast Cancer Cells
by: Kaisheng Liu, et al.
Published: (2019-12-01)

Maggot extracts chemo-prevent inflammation and tumorigenesis accompanied by changes in the intestinal microbiome and metabolome in AOM/DSS-induced mice
by: Xun Tang, et al.
Published: (2023-05-01)

Cytosolic Hsp90 Isoform-Specific Functions and Clinical Significance
by: Samarpan Maiti, et al.
Published: (2022-08-01)

Hsp90: From Cellular to Organismal Proteostasis
by: Milán Somogyvári, et al.
Published: (2022-08-01)

A Comparative Transcriptomic Analysis Reveals That HSP90AB1 Is Involved in the Immune and Inflammatory Responses to Porcine Deltacoronavirus Infection
by: Yujia Zhao, et al.
Published: (2022-03-01)

PI3K-activated MSC proteomes inhibit mammary tumors via Hsp90ab1 and Myh9
by: Xun Sun, et al.
Published: (2022-09-01)

Role of Heat Shock Proteins (HSP70 and HSP90) in Viral Infection
by: Anna Lubkowska, et al.
Published: (2021-08-01)

Kajian Heat Shock Protein 90 (HSP90) dalam Pencarian Kandidat Penghambatnya melalui Ekplorasi Bahan Alam Indonesia
by: Rehmadanta Sitepu
Published: (2019-03-01)

Hsp90 the concertmaster: tuning transcription
by: Nidhi eKhurana, et al.
Published: (2015-04-01)

A Pan-Cancer Analysis of Heat-Shock Protein 90 Beta1(HSP90B1) in Human Tumours
by: Yaxuan Wang, et al.
Published: (2022-09-01)

Priming with HDAC Inhibitors Sensitizes Ovarian Cancer Cells to Treatment with Cisplatin and HSP90 Inhibitors
by: Ana J. Rodrigues Moita, et al.
Published: (2020-11-01)

Heat Shock Protein 90 (Hsp90) Expression and Breast Cancer
by: Christos A. Papadimitriou, et al.
Published: (2012-09-01)

Upregulation of TGF-β-induced HSP27 by HSP90 inhibitors in osteoblasts
by: Gen Kuroyanagi, et al.
Published: (2022-05-01)

Targets Fishing and Identification of Calenduloside E as Hsp90AB1: Design, Synthesis, and Evaluation of Clickable Activity-Based Probe
by: Shan Wang, et al.
Published: (2018-05-01)

Decreased Expression of Heat Shock Protein HSP90α after Exposure to Doxorubicin in Breast Cancer Cell Lines (MCF-7 and MDA-MB-231)
by: Fereshte Jokar, et al.
Published: (2017-02-01)

The APE2 Exonuclease Is a Client of the Hsp70–Hsp90 Axis in Yeast and Mammalian Cells
by: Siddhi Omkar, et al.
Published: (2022-06-01)

Development of the first geldanamycin-based HSP90 degraders
by: Silas Wurnig, et al.
Published: (2023-06-01)

Structure-Activity Relationships of Benzothiazole-Based Hsp90 C-Terminal-Domain Inhibitors
by: Jaka Dernovšek, et al.
Published: (2021-08-01)

Effect of HSP90AB1 and CC domain interaction on Bcr-Abl protein cytoplasm localization and function in chronic myeloid leukemia cells
by: Yuhang Peng, et al.
Published: (2021-07-01)

The Chaperone System in Tumors of the Vocal Cords: Quantity and Distribution Changes of Hsp10, Hsp27, Hsp60, and Hsp90 during Carcinogenesis
by: Alessandro Pitruzzella, et al.
Published: (2024-01-01)

Exploring the Prominent and Concealed Inhibitory Features for Cytoplasmic Isoforms of Hsp90 Using QSAR Analysis
by: Magdi E. A. Zaki, et al.
Published: (2022-03-01)

Development of machine learning models for the screening of potential HSP90 inhibitors
by: Mohd Imran Khan, et al.
Published: (2022-10-01)

Patient-Derived Pancreatic Cancer Cells Induce C2C12 Myotube Atrophy by Releasing Hsp70 and Hsp90
by: Hong-Yu Wu, et al.
Published: (2022-09-01)

Targeting the lncMST-EPRS/HSP90AB1 complex as novel therapeutic strategy for T-2 toxin-induced growth retardation
by: Qirong Lu, et al.
Published: (2022-12-01)

High-Throughput Screen of Natural Product Libraries for Hsp90 Inhibitors
by: Jason Davenport, et al.
Published: (2014-02-01)

Natural HSP90 inhibitors as a potential therapeutic intervention in treating cancers: A comprehensive review
by: Hui Yi Liew, et al.
Published: (2022-07-01)

Hsp70 and Hsp90 Elaborately Regulate RNAi Efficiency in <i>Plutella xylostella</i>
by: Sujie Lin, et al.
Published: (2023-11-01)

High expression of HSP90 is associated with poor prognosis in patients with colorectal cancer
by: Shuming Zhang, et al.
Published: (2019-10-01)

Extracellular Heat Shock Protein-90 (eHsp90): Everything You Need to Know
by: Daniel Jay, et al.
Published: (2022-06-01)

Hsp90 inhibition leads to an increase in surface expression of multiple immunological receptors in cancer cells
by: Madison Wickenberg, et al.
Published: (2024-04-01)

S-glutathionylation of Hsp90 enhances its degradation and correlates with favorable prognosis of breast cancer
by: Yu-Yin Shih, et al.
Published: (2022-11-01)

Inhibition of HSP90 in Driver Oncogene-Defined Lung Adenocarcinoma Cell Lines: Key Proteins Underpinning Therapeutic Efficacy
by: Ángela Marrugal, et al.
Published: (2023-09-01)

Feasibility and safety of targeting mitochondria for cancer therapy – preclinical characterization of gamitrinib, a first-in-class, mitochondriaL-targeted small molecule Hsp90 inhibitor
by: Umar Hayat, et al.
Published: (2022-12-01)