Predictive biomarkers for 5‐ALA‐PDT can lead to personalized treatments and overcome tumor‐specific resistances

Predictive biomarkers for 5‐ALA‐PDT can lead to personalized treatments and overcome tumor‐specific resistances

Abstract Background Photodynamic therapy (PDT) is a minimally invasive, clinically approved therapy with numerous advantages over other mainstream cancer therapies. 5‐aminolevulinic acid (5‐ALA)‐PDT is of particular interest, as it uses the photosensitiser PpIX, naturally produced in the heme pathwa...

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Bibliographic Details
Main Authors: Maria Mastrangelopoulou, Mantas Grigalavicius, Tine H. Raabe, Ellen Skarpen, Petras Juzenas, Qian Peng, Kristian Berg, Theodossis A. Theodossiou
Format: Article
Language:English
Published: Wiley 2022-12-01
Series:Cancer Reports
Subjects:
5‐aminolevulinic acid
ABCG2 transporters
antioxidant defenses
ferrochelatase
heme oxygenase
metabolism
Online Access:https://doi.org/10.1002/cnr2.1278

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