A systematic immunoprecipitation approach reinforces the concept of common conformational alterations in amyotrophic lateral sclerosis-linked SOD1 mutants

A systematic immunoprecipitation approach reinforces the concept of common conformational alterations in amyotrophic lateral sclerosis-linked SOD1 mutants

Mutations in the Cu, Zn superoxide dismutase (SOD1) gene are one of the causative agents of amyotrophic lateral sclerosis (ALS). Although more than 100 different mutations in SOD1 have been identified, it is unclear whether all the mutations are pathogenic or just single nucleotide polymorphisms (SN...

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Main Authors: Takao Fujisawa, Namiko Yamaguchi, Hisae Kadowaki, Yuka Tsukamoto, Naomi Tsuburaya, Atsushi Tsubota, Hiromitsu Takahashi, Isao Naguro, Yuji Takahashi, Jun Goto, Shoji Tsuji, Hideki Nishitoh, Kengo Homma, Hidenori Ichijo
Format: Article
Language:English
Published: Elsevier 2015-10-01
Series:Neurobiology of Disease
Subjects:
Amyotrophic lateral sclerosis
Mutant SOD1
ER stress
Mutant SOD1-specific antibody
ELISA
Common conformational change
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115300310

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