Oncofetal protein IGF2BP1 regulates IQGAP3 expression to maintain stem cell potential in cancer

Oncofetal protein IGF2BP1 regulates IQGAP3 expression to maintain stem cell potential in cancer

Summary: We reported earlier that IQGAP3 is an important stem cell factor in rapidly proliferating isthmus stem cells in the stomach and that IQGAP3 expression is robustly induced in terminally differentiated chief cells and de-differentiated cells following tissue damage. The elevated IQGAP3 expres...

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Bibliographic Details
Main Authors: Khine Myint, Linda Shyue Huey Chuang, Yu Xuan Teh, Nur Astiana Mawan, Edward Jizhong Shi, Michelle Meng Huang Mok, Napat Nuttonmanit, Junichi Matsuo, Ying Li, Henry Yang, Atsushi Okabe, Atsushi Kaneda, Motomi Osato, Jimmy Bok-Yan So, Wei Peng Yong, Patrick Tan, Khay Guan Yeoh, Yoshiaki Ito
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:iScience
Subjects:
Cell biology
stem cells research
cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222014663

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